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Biomedical subjects

N D Greyson

Publications and source records attributed to N D Greyson.

At least 37 records · Page 2Linked to original sources
PubMed1983

Predicting nodal metastases in breast cancer by lymphoscintigraphy.

In a prospective trial, 89 women with breast lumps underwent bilateral axillary and internal mammary lymphoscintigraphy preoperatively, using technetium-99m antimony sulfide colloid. All scans were interpreted blindly by three separate observers. Breast biopsy was then performed; if the biopsy specimen showed malignant tumour, definitive therapy was performed with axillary dissection. The interpretation of the axillary and internal mammary lymphoscintigrams was subsequently compared with the histologic assessment of the axillary nodes. Of the 89 women, 54 had benign disease and 35 had cancer. The internal mammary lymphoscintigram was considered to show abnormality in only 1 of the 54 patients with benign disease. One patient with cancer was eliminated from the review. Sixteen of the remaining 34 patients had axillary node metastases. Of these, 8 had an abnormal internal mammary lymphoscintigram. Only 2 of the 18 patients with cancer but no axillary metastases had an abnormal internal mammary lymphoscintigram. One bilateral axillary lymphoscintigram in the 54 patients with benign disease was discarded for technical reasons. The axillary lymphoscintigram was accurate in 52 of the remaining 53 patients. Two such scintigrams in the 35 patients with breast cancer were discarded for technical reasons. The axillary lymphoscintigram indicated abnormalities in 12 of 16 patients with axillary nodal metastases but appeared normal in 13 of 17 patients without axillary metastases. Lymphoscintigraphy may play a valuable role in the staging of breast cancer in the future.

Antimony↗
PubMed1982

Radionuclide evaluation of spontaneous femoral osteonecrosis.

Spontaneous osteonecrosis of the femoral condyle in 40 knees was followed by sequential radiographs and three-phase bone scans using 99mTc-methylene diphosphonate. The characteristic bone scan appearance of focal increased uptake by the medial femoral condyle in blood flow, blood pool, and delayed images helped to make the specific diagnosis in 11 knees that had no characteristic radiographic findings at the time of presentation. The three phases of the bone scan demonstrated a pattern that was useful in determining the activity of the process. There was a gradual loss of hyperemia as healing progressed. Late bone scans were normal or showed nonspecific findings. Radionuclide bone scans were able to confirm or exclude this disease and were superior to radiographs in demonstrating the disease in the acute phase.

Aged↗
PubMed1982

Radionuclide salivary scan imaging of a "functioning" malignant parotid tumor (mucous-producing papillary adenocarcinoma).

To date, all "functioning" or "hot" tumors on salivary gland scan have been benign - either the not uncommon Warthin's tumor or the rare oncocytoma. A positive salivary scan was obtained in a functioning malignant tumor of the parotid gland (a mucous-producing papillary adenocarcinoma). This occurrence has not previously been reported. The pathologic findings and the radionuclide images are demonstrated in this elderly female. It is presumed that the Technetium Tc99m pertechnetate has been concentrated in the tumor. The functioning epithelial cell, however, is not the benign oncocyte associated with other previously reported benign functioning tumors. Clinical discretion is therefore suggested in interpreting the significance of a functioning salivary gland tumor if encountered in an elderly female.

Adenocarcinoma, Papillary↗
PubMed1981

The case of the missing vault: a "cold" bone lesion following electrical burn.

Osteonecrosis of the skull produced by an electrical burn presented as a dramatic "cold" bone lesion on an MDP bone scan, despite normal skull radiographs. Four months later the skull radiograph showed marked bone resorption, and the three-phase bone scan confirmed healing and new osteoblastic activity. The pathophysiology of high-voltage injuries is outlined.

Burns, Electric↗
PubMed1981

The variable bone scan appearances of nonosteogenic fibroma of bone.

Ten radiographically diagnosed fibrous defects of bone were assessed by three-phase bone scanning. Normal scans are obtained when the lesion is quiescent of has fully heated. Mild hyperemia and moderate bone uptake is present during the healing phase and is not significant. More intense hyperemia and a markedly positive bone scan suggest that a more active process, such as fracture or tumor, may be present.

Adolescent↗
PubMed1981

Bone scanning in assessing viability of vascularized skeletal tissue transplants.

One hundred and eight bone scans using 99mTechnetium methylene diphosphonate (MDP) were performed in rats undergoing vascularized and nonvascularized syngeneic and allogeneic transplants of the hind limb, and in control animals. A six-level system of grading the radionuclide uptake in the graft was used to evaluate healing or complications of the transplantation. Bone scanning was superior to other modalities in assessing viability of the graft. Bone scans were able to: (1) immediately confirm vascular patency, thus obviating angiography; (2) demonstrate differences in the rate of repair in syngeneic and allogeneic nonvascularized grafts; (3) sequentially assess vascularized allograft rejection; and (4) document long-term effects, such as bone atrophy due to disuse and early epiphyseal maturity.

Animals↗
PubMed1980

Familial Warthin's tumor. 1. Its synchronous occurrence in mother and son. 2. Its association with cystic oncocytic metaplasia of the larynx.

Warthin's tumor of the parotid gland is an unusual tumor for which a number of theories of pathogenesis have been advanced through the years, ranging from a branchiogenic origin to an embryonic lymph node origin to true neoplasia from parotid epithelial duct cells. Recently Allegra has suggested that Warthin's tumor may be a hypersensitivity disease. Presented here are two unique cases of Warthin's tumor, having both a familial relationship (synchronous occurrence in mother and son) and the association with cystic oncocytic metaplasia of the larynx. Observations lead to the conclusion that the lesion is primarily metaplastic, not neoplastic, with a secondary lymphoid reaction of the delayed hypersensitivity type.

Adenolymphoma↗
PubMed1978

Radionuclide test for gastric bile reflux.

The authors conducted a study using radioactive endogenous bile to detect gastric bile reflux in healthy volunteers and patients suspected of having bile gastritis. When 7 muCi of pyridoxylideneglutamate of hydroxyiminodiacetic acid labelled with technetium-99m is injected intravenously it is excreted by hepatocytes, and sequential gamma camera images visualize the bile ducts and show subsequent activity in the gut. Following such an injection, the authors determined the presence of isotope-labelled bile in the stomach in fasting subjects by assaying count rates in serial gastric aspirates obtained by means of a nasogastric tube positioned in the antrum. The results were related to the clinical history and gastroscopic findings. In normal persons only extremely low counts were detected, possibly due to free activity; high counts (in excess of 50 000/min) indicated abnormal reflux. It is suggested that this test is a useful adjunct, and is more physiologic than endoscopy, in the assessment of bile reflux.

Bile↗
PubMed1977

Delayed imaging to distinguish bone lesions from urinary tract activity.

In 28/1,400 patients examined by bone imaging two hours after injection of 99mTc-polyphosphate or diphosphonate, it was found that activity in the urinary tract obscured the bony pelvis, making assessment of this region difficult or impossible. In several patients additional images were obtained 24 hours after the injection when decreased activity in the urinary tract allowed the pelvis to be more satisfactory visualized.

Aged↗
PubMed1977

Sophisticated radiology in otolaryngology. I. Diagnostic imaging: roentgenographic (x-ray) modalities.

Conventional radiography is now complemented by a large range of newer radiologic diagnostic techniques, involving both roentgenographic and non-roentgenographic modalities. It is the purpose of this presentation to present these new roentgenographic modalities in graphic form, and demonstrate their application to otolaryngic diagnosis. The major roentgenographic modalities which will be stressed are: xeroradiography, angiography, and computerized tomographic scanning.

Adolescent↗