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Biomedical subjects

N Conte

Publications and source records attributed to N Conte.

At least 55 records · Page 3Linked to original sources

Variations in some of the body fluid hormone levels currently used for endocrine monitoring during the third trimester of pregnancy.

We have investigated the variability of four hormonal parameters used for the endocrine monitoring of the third trimester of pregnancy (E3, E4, HPL, SP1). We have observed no circadian rhythm of Estriol, Estetrol, HPL, and SP1. The within-a-day and the day-to-day variations are much greater for E4 than for E3 and for HPL than for SP1. The standard deviations were great for the steroids, especially for E4 and much less for the protein hormones, especially SP1. This implies that it is necessary to have serial assays of the steroids to have any confidence in the levels, while good monitoring could be guaranteed with a smaller number of assays for HPL, and SP1.

Circadian Rhythm↗

Alpha-fetoprotein and beta-human chorionic gonadotropin in amniotic fluid.

A series of data on amniotic fluid levels of alpha-fetoprotein (AFP) and beta-human chorionic gonadotropin (HCG) are presented. Both hormones were observed to decrease with advancing gestational age. The diagnostic importance of AFP levels is confirmed, and the very high levels of beta-HCG in twin gestations are documented. A statistically significant correlation between the concentration of both hormones is demonstrated.

Amniotic Fluid↗

[Basal prolactinemia and level after stimulation with TRH in juvenile gynecomastia].

TSH and PRL in basal conditions and after stimulus with TRH, gonadotrophin in basal conditions and after stimulus with GnRH, plasma testosterone, urinary oestrogens and peripheral thyroid hormones have been evaluated in 11 subjects with puberal gynaecomastia, 7 with post-puberal gynaecomastia and 14 normal controls. With respect to the normal controls, only patients with post-puberal gynaecomastia showed higher levels of basal PRL and after TRH stimulus. The behaviour of these patients could suggest that in subjects with post-puberal gynaecomastia there may be persistent endocrine imbalance, whereas in puberal gynaecomastia such imbalance is only transitory and is exhausted prior to the onset of mammary tumefaction.

Adolescent↗

[Radioimmunological determination of insulin in the amniotic fluid].

Small amounts of immunoreactive insulin, at about one-eighth the concentrations found in maternal serum, have been detected in human amniotic fluid. A positive correlation between term amniotic fluid insulin levels and newborn birth weight was found. Insulin was studied in 42 samples of amniotic fluid obtained from normal and pathological pregnancies by radioimmunoassay. In only one sample of amniotic fluid of diabetic mother with insulin dependence we found high values of insulin and condition of insufficient fetal lung maturity. We believe that radioimmunoassay of insulin in amniotic fluid may be a parameter of evaluation of fetal maturity.

Adult↗

[Creatinine in the amniotic fluid].

Creatinine concentration in the amniotic fluid during the latter half of pregnancy was investigated by single determinations in 39 patients and serial determinations in 2 patients. Concentrations of creatinine remained constant or increased very gradually up to approximately 34 weeks, at which point a more abrupt increase apparently took place so that after 37 weeks the level was 1,5 mg. Physiologically, these data lend support to the commonly held theory of fetal urine as an additive source of amniotic fluid. Clinically, they suggest that assay of creatinine might prove useful in estimation of fetal maturity.

Adult↗

[Placental lactogen (HPL) in amniotic fluid].

Human placental lactogen (HPL) was analyzed in 52 samples of amniotic fluid. Assays of liquor HPL appear to aid in the evaluation of the degree of fetal involvement with erythroblastosys. The measurement of HPL in amniotic fluid may yet be proved also in the management of mothers with diabetes.

Amniotic Fluid↗

Demonstration of human chorionic gonadotropin during the second half of the menstrual cycle in plasma of regularly menstruating women users of copper IUds.

An attempt has been made of demonstrating the beta subunit of HCG in the plasma of 13 regularly menstruating women wearing a copper IUD. Eighteen menstrual cycles were explored with a total of 94 specimens obtained at 3-day intervals starting from the 16th day of the cycle. A cross reaction with LH was excluded by simultaneous assay of this hormone. Progesteron was also assayed so as to exclude anovulatory cycles. Five out of 12 ovulatory cycles yelded positive results with HCG values ranging from 171 to 692 mIU per ml. We therefore agree with the hypothesis according to which copper IUDs do not interfere with fecundation but with subsequent stages, specifically about the time of nidation of the blastocyst in the uterus.

Adult↗

[Case of pseudopseudohypoparathyroidism].

A case of pseudo-pseudo-parathyroidism, in which normal blood chemistry data were accompanied by marked shortening of the 4th metacarpus and metatarsus, and a suggestion of syndactyly, is reported.

Adult↗