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Biomedical subjects

N Carp

Publications and source records attributed to N Carp.

At least 19 recordsLinked to original sources
PubMed1991

Contribution of patient history to the glutathione S-transferase activity of human lung, breast and colon tissue.

Overexpression of the glutathione S-transferases (GSTs) and their involvement in the detoxification of anticancer agents has prompted numerous investigations of the enzyme activity of human tumor tissue. This study represents an in-depth evaluation of the contribution of patient history and pathological status to the GST activity of various human tissues. GST activity was elevated significantly in tumors of the lung, breast and colon as compared to unmatched and matched normal tissue from the same organ. The GST activity of primary breast tumors varied significantly with the stage of the tumor. Breast tumors previously treated with both radiation and chemotherapy had significantly lower levels of GST activity than untreated tumors. Neither progesterone nor estrogen receptor content was associated with the GST activity in primary breast tumors. Colon metastases possessed higher levels of GST activity than primary colon tumors but enzyme activity was independent of the Duke's classification of the tumor. Only tumors of the left colon had levels of GST activity that were higher than those of adjacent normal mucosa. No relationship was evident between either age or sex and the GST activity of any of the tissues examined. GST activity levels may reflect the site-specific ability of tissues to provide cellular protection against xenobiotics.

Biomarkers, Tumor↗
PubMed1984

Orbital, sphenoidal ridge and spinal meningiomas occurring in one patient.

From the more than 1500 intracranial meningiomas, 600 spinal meningiomas and 400 orbital tumours operated on in our clinic between 1935-1980 we are reporting the case of a patient with multiple meningiomas which gradually developed in three different regions - right orbital, the left sphenoidal ridge and the upper thoracic region. We have not found any comparable case with these features in the medical literature. From the clinical, radiological and scintigraphic findings we established the coexistence and the gradual development of these multiple meningiomas in three different regions. The correlation of the clinical and paraclinical findings offered us the presumptive diagnosis of multiple orbito-cranial and spinal meningiomas before the last two operations.

Adult↗
PubMed1981

Persistent vegetative state after multiple trauma. A clinicopathologic study.

The clinico-pathological findings are reported in a case with persistent vegetative state after multiple cerebral lesions. The lesions are small in size, and are situated at different levels of the CNS, some of them being important in the maintenance of wakefulness and motor initiative. The differential diagnosis and the isolation of such a syndrome are discussed.

Adult↗
PubMed1980

Induction of neovascularization by mitogen-activated spleen cells and their supernatants.

The first objective of the experiment was to demonstrate that murine spleen cells treated with the T cell mitogen phytohemagglutinin induced neovascularization when adoptively transferred to the chorioallantoic membrane of chicken eggs. The second objective was to show that neovascularization could be induced by the supernatants from these cultures. The assay for neovascularization was based on the well established observation that angiogenesis can be induced on the chorioallantoic membrane by tumors and other substances. The supernatants were incorporated into a slow release polymer of hydroxyethylmethacrylate so as to produce a sustained release of the angiogenic material. The results showed that phytohemagglutinin activated spleen cells and their culture supernatants induced neovascularization on the chorioallantoic membrane. The significance of these observations are discussed as they relate to the hypothesis of lymphoid-induced neovascularization during tumor growth and other types of immunological inflammatory reactions.

Allantois↗
PubMed1977

Spinal dissemination following operation on cerebral oligodendroglioma.

This paper concerns two cases of cerebral oligodendroglioma (intraventricular in one case, right temporal in the other), with spinal dissemination (cervical and upper thoracic respectively), manifested clinically 2 years and 14 months respectively after removal of the cerebral tumour. Anatomical examination confirmed the diagnosis of disseminated oligodendroglioma in the leptomeninges in both cases and also in the parenchyma in the second case.

Adult↗
PubMed1977

Spinal dermoid tumours.

The present work is a detailed analysis of 12 cases of spinal dermoid tumours operated on between 1935 and 1976. Of these 11 were medullary (3 intramedullary and 8 subdural extramedullary), representing an incidence of 0-80% of medullary tumours, and 1 was an extraspinal coccygeal tumour. Most of the tumours were located in the spinal canal and conus. Good results were obtained following total ablation in 7 cases and partial removal of the tumour in 5 cases.

Adolescent↗
PubMed1976

Cerebral dermoid tumours.

Four cases of cerebral dermoid tumour with an intraventricular, occipital and sellar location are reported, representing 0.04% of the verified cerebral tumours in the authors' statistics. A recurrence occurred after one year in the first case of intraventricular dermoid tumour; after the second operation aseptic meningitis developed and the patient died. In the second case microscopic examination revealed aspects of malignant transformation of the tumour. The symptoms did not differ from those of other cerebral tumours. Operations should be radical whenever possible, avoiding dispersion of the tumour contents in order to prevent a recurrence or aseptic meningitis.

Adult↗
PubMed1975

Intracranial ganglioneuromas in children.

Two cases of tumours of the sellar and suprasellar region in children, manifested clinically by visual and endocrine disturbances, are reported. In both cases surgical removal of the intracranial tumour was performed. The histological diagnosis was central ganglioneuroma, an extremely rare tumour in children. Also worthy of note was the altogether exceptional location in these children of central ganglioneuromas in the sellar and suprasellar region.

Brain Neoplasms↗
PubMed1975

Intrasellar abscess.

A case of intrasellar abscess in a 31-year-old male, with pituitary insufficiency, visual field and acuity disturbances, is reported. In the pus extracted at surgery E. coli and Staphylococcus haemolyticus were identified. The patient died 20 days after the operation. Necropsy revealed the fibrous capsule of an abscess in the hypophyseal region and putriform tissue at the level of the hypothalamus, with three small tumours one of which proved to be a craniopharyngioma.

Adult↗
PubMed1975

Giant cell tumors of the calvaria.

The authors report and discuss four rare cases of primary, giant cell tumor of the cranial vault, a usually benign tumor that develops in young patients and has an extremely low rate of latent malignancy. The authors believe the preferred treatment to be total surgical removal of the tumor; only in rare cases of malignancy when the tumor is impossible to remove totally should this be combined with radiotherapy. Associated minor trauma played only a tumor-revealing role and was not involved in the etiology.

Adult↗