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Biomedical subjects

N Cajal

Publications and source records attributed to N Cajal.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Passive hemagglutination and complement fixation reactions in the early diagnosis of Mycoplasma pneumoniae infections.

Complement fixation (CF) and passive hemagglutination (PHA) tests (the latter with a M. pneumoniae antigen coupled by glutaraldehyde onto red blood cells) were performed in 263 patients with various infectious diseases (mostly in the 1st and 2nd week after onset) and non-infectious ones. CF reaction proved to be inappropriate for the early etiological diagnosis of mycoplasma infections, since the high titers were distributed undifferentially among the various patient groups and many sera (38%) showed anticomplementary activity. A PHA titer of at least 1/128 (preferably of 1/512) points to the presence of a M. pneumoniae infection, especially if clinical, radiological and laboratory data suggest a nonbacterial or mixed pneumonia. The diagnosis is often early enough to orientate the etiological therapy towards macrolides and tetracyclines. The PHA reaction recommended is specific, sensitive, reproducible and easy to perform.

Complement Fixation Tests↗
PubMedDate not supplied

[Importance of the virology laboratory in the diagnosis of virus diseases].

Introduction. Principles of the Modern Diagnosis in Virology--isolation of the causative agent;--histologic and electronoptical diagnosis;--serologic. Efficiency of the viral diagnosis. Modern and Rapid Diagnostic Methods--progress in the technology of cell cultures and immunofluorescence;--new serologic methods.

Humans↗
PubMedDate not supplied

[Herpetic etiology of gastric and duodenal ulcer. II. Study in humans].

By inducing experimental ulcers in the rabbit with the type 1 Herpes simplex strain, isolated from the herpes vesicles from a vagotomized patient, the authors demonstrate the protective role of vagotomy, the ulcerogenic capacity of the virus, which can be considered as an etiological factor of human gastroduodenal ulceration. They also discuss the possibilities for a new medical therapy of this disturbance.

Animals↗
PubMedDate not supplied

The continuous decrease in the number of SSPE annual cases ten years after compulsory anti-measles immunization.

The record of SSPE cases diagnosed immunochemically and serologically in our laboratory, standing for about 60% of the total new cases reported in our country, shows a significant decrease in the incidence in 1988-89 (from 5.21 new cases per year per million total population in 1987 to 1.82 cases in 1988). In 85% of the patients, SSPE onset occurred at the age of 10 years or more, suggesting the possibility of a primary measles infection before anti-measles immunization became compulsory. High serum and CSF anti-measles antibody titres in recently diagnosed patients show subclinical long-term courses. Further serologic tests for viruses inducing persistent infections (herpes viruses, AgHBs and HIV) do not show any difference when compared to a control group excepting an increased incidence of anti-cytomegalic titres.

Age Factors↗
PubMedDate not supplied

Study of cell surface antigens induced by herpes simplex virus. Note I. Identification of the antigens by means of protein A-containing staphylococci.

A rapid, easy-to-perform and specific technique for the visualization of herpes simplex virus (HSV)-induced cell surface antigens is described. The technique consists in the incubation of HSV-infected cells with hyperimmune HSV antiserum and formation of rosettes with FITC-labelled Cowan strain staphylococci containing protein A. The "nonspecific background" of the reaction can be estimated by comparison with the rate of bacteria binding by control cells not incubated with HSV antiserum.

Antigens, Surface↗
PubMedDate not supplied

Some results obtained in the "Stefan S. Nicolau" Institute of Virology by the study of herpes simplex virus.

The results obtained in the "Stefan S. Nicolau" Institute of Virology by the study of herpes simplex virus (HSV) are reviewed. The investigations were mainly focused on HSV biology, genetic markers, experimental HSV infection, correlation between HSV and some diseases, action of some chemical and biological preparations on HSV, in vitro and in vivo HSV oncogenicity, HSV-induced surface antigens, a.o.

Animals↗
PubMedDate not supplied

Study of cell surface antigens induced by herpes simplex virus. Note II. Some properties of the antigens.

Surface antigens induced by herpes simplex virus infection in HeLa cells remain unaltered after treatment of the cells with 2% formalin for 10 min or with 0.08% trypsin for 15 min at 37 degrees C. A longer trypsin treatment (for 1 hour) will cause gradual alterations in the virus-induced antigens. Hence, these antigens are proteins deeply implanted within the cellular membrane. Their mobility--optimal at 37 degrees C--allows aggregation of the antigens in the form of caps or patches by polyvalent ligands such as IgG.

Antigens, Surface↗