Search PubMed⌕ Search

Biomedical subjects

N C Tan

Publications and source records attributed to N C Tan.

At least 37 records · Page 2Linked to original sources
PubMed1990

Left main coronary artery obstruction: surgical experience with 93 patients.

Among patients with ischemic heart disease, those with left main stem coronary artery stenosis has attracted most attention due to their ominous prognosis. During the period from August 1982 to February 1989, 93 patients underwent left main coronary artery revascularisation procedures at Singapore General Hospital. All the patients had greater than 75% obstruction of the left main coronary artery. Significant triple vessel disease occurred in 35 patients (37.6%), double vessel disease in 32 patients (34.4%), single vessel disease in 21 patients (22.6%) and left main coronary as an isolated lesion in 5 patients (5.4%). The overall hospital mortality rate is 6.5% and perioperative infarction rate is 8.6%. Since mid-1985, the hospital mortality rate has been reduced to 3.7% and the perioperative infarction rate to 4.9%. Average grafts per patient was 3.5. Intra-aortic balloon pump was used in 5 patients. Follow up period was from 5 months to 84 months with a mean of 36 months with the majority of patients in either New York Heart Association Class I or II and still alive.

Cardiac Catheterization↗
PubMed1985

Musical murmur and cardiac shudder.

When echocardiographic studies show several structures vibrating at a similar frequency to an associated musical cardiac murmur, the structure vibrating most strongly may localize the origin of the murmur.

Adolescent↗
PubMed1982

Thoracic and cardiovascular surgery in Singapore.

Thoracic and Cardiovascular Surgery started in Singapore on the initiative of a number of the leading general surgeons working in general surgical units in the public institutions. Initially, only thoracic surgery was done. This was followed about 15 years later with cardiovascular surgery. A decision was made to establish a Thoracic Surgical Unit at the Tan Tock Seng Hospital in 1965. The Head of Department was appointed. Space had become available at this hospital following the very successful anti-tuberculosis chemotherapy programme. The department was set up in December 1966. It grew steadily over the years. As in other similar centres, the spectrum of patients that underwent operations in the department became predominantly cardiovascular in nature. In December 1981, this department was transferred to the Singapore General Hospital where specialised facilities based on the experience of the surgical team had been installed.

Cardiac Surgical Procedures↗
PubMed1982

Annals of the Academy of Medicine of Singapore.

Shortly after the inauguration of the Academy of Medicine in 1957, the idea of bringing out a journal to be called the "Annals" was considered. It was not until in 1972 that a regular quarterly publication entitled the Annals of the Academy of Medicine was possible. To serve the different specialist disciplines that are embodied in the Academy of Medicine, the Annals has orientated its issues to cover various specialised topics. The contribution of Guest Editors has enhanced the scope of the Annals, thereby enabling it to serve the wide-ranging interests of its members. The listing of the Annals in the Index Medicus in 1979 was an important milestone in the development of the Annals. With the appointment of a full-time Editorial Assistant in 1981, the Annals is now on a much firmer footing to establish itself as a journal of international repute.

Academies and Institutes↗
PubMed1981

Primary carcinoma of the lung.

118 patients with carcinoma of the lung seen in the Department of Cardiovascular and Thoracic Surgery, Tan Tock Seng Hospital, Singapore were followed for five years. The aim was to determine the survival of these patients in relation to the stage of the disease as well as the histologic type of carcinoma. 22 patients were in stage 1, 13 in Stage II and 83 in Stage III. Thoracotomy was performed in 62 patients and the rest had biopsy of distal lymph nodes. 43.3% of the carcinoma were squamous cell, 25% adenocarcinoma, 27% large cell, anaplastic, 2.9% oat cell and 1.8% bronchoalveolar cell carcinoma. Survival of the patients were found to be closely related to stage of the disease but not with the histologic type.

Adult↗
PubMed1981

Surgical management of rheumatic heart disease in Singapore.

Over the last three decades there has been a world-wide decline in the incidence and severity of rheumatic fever and rheumatic heart disease, but the death rate in Singapore from chronic rheumatic heart disease has risen from 3.6 per 100,000 population in 1966 to 4.4 per 100,000 in 1977. Valvular lesions from rheumatic heart disease are very common, and between 1967 to 1979, 715 surgical procedures were performed for rheumatic valvular disease, and of these, 654 procedures involved the mitral valve which was most commonly affected by the disease process. Since many of the patients were female and in the child-bearing age, conservative procedures on the mitral valve were performed whenever possible. Mitral valvotomy for mitral stenosis relieved symptoms effectively; and for restenosis of the mitral valve, more than half of the patients underwent a second valvotomy with functional improvement. Mitral valve replacement was reserved for the severely distorted valve, sometimes calcified, and where there was stenosis associated with incompetence. Between 1971 to 1979, 162 mitral valves were replaced and actuarial studies showed 80% survival five years after surgery. 30 aortic and mitral valve replacements were performed in this same period with an operative mortality of 16.7%. Only 75 aortic valves were replaced for rheumatic valvular disease and 14 of these also had associated mitral and triscuspid valve disease. The prosthetic valves commonly used for replacement were the Starr-Edwards non-cloth covered valves, models 6120 and 1260. All patients that had valve replacements were treated with long-term anticoagulation with Warfarin. The incidence of thromboembolism was low, being 8% for mitral valve replacement and the majority of these episodes occurred in the first three months after surgery.

Adolescent↗
PubMed1980

Surgical management of ventricular septal defect in infancy.

Symptomatic ventricular septal defects in infants who responded poorly to intensive medical therapy require surgical intervention. This paper aims to compare the results of the two stage approach of initial pulmonary artery banding followed by debanding and ventricular septal defect closure with primary intracardiac repair in infancy. Thirty-six infants underwent pulmonary artery banding between 1968-1979 with two operative deaths (5.6%). Eighteen patients underwent pulmonary artery debanding and closure of ventricular septal defect between 1971-1979 with five operative deaths (25.6%). However during 1978-1979 ten patients underwent 2nd stage repair with no operative death. During the same period primary intracardiac repair in infancy was carried out in nine infants with three operative deaths (33.3%). There appears to be still a place for two stage treatment of symptomatic ventricular-septal defect in critically ill infants certain situation.

Cardiac Surgical Procedures↗
PubMed1980

Surgery for mitral restenosis.

Four hundred and twenty-five patients underwent mitral valvotomy between 1960 and 1979, the majority by the closed method. Thirty-two patients required another operation for mitral restenosis. There was high incidence of reoperation after the 6th and 7th years (23.3%) and after the 9th and 10th years (26.4%) postoperatively. Sixteen patients (47%) with restenosis underwent a second closed mitral valvotomy with a satisfactory result, 12 patients (35.4%) required valve replacement, and 6 patients (17.6%) had an open valvotomy. Another valvotomy for pure mitral restenosis can give satisfactory results, but where the valve is severely deformed or incompetent, valve replacement is preferred.

Adolescent↗
PubMed1977

A case of myasthenia gravis with thyrotoxicosis treated by combined subtotal thyroidectomy and total thymectomy.

Thyrotoxicosis occurring in conjunction with myasthenia gravis is rare. The usual treatment consists of medical control of the thyrotoxicosis, then thymectomy and later subtotal thyroidectomy. The case reported here concerns a 19-year-old girl who had surgical treatment for both lesions on the same occasion. With proper medical preparation, modern anaesthesia and respiratory care, the surgical treatment of both lesions can be accomplished in one stage.

Adult↗
PubMed1977

Atrial myxoma.

Explore the source record for details and available documents.

Adult↗
PubMed1975

Ventricular septal deffect and aortic imcompetence: clinical and haemodynamic study of 12 cases.

The incidence of aortic incompetence complicating ventricular septal defect has been estimated as varying from 2-5% (Glasser et alii, 1972) to 5% (Nadas et alii, 1964). Although numerous publications have appeared describing the clinical, pathological and surgical aspects of this syndrome in different parts of the world, documentation of its occurrence in Asian patients has been rare except for reports from Japan (Tatsuno et alii, 1973; Mizuno and Saegusa, 1967). This paper describes our experience of 12 cases collected over 10 years.

Adolescent↗