Some analyses of the information processing and sensory capacities of alcoholic Korsakoff patients.
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Biomedical subjects
Publications and source records attributed to N Butters.
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Recovery of a spatial delayed alternation habit following partial frontal lesions was investigated in mature rhesus monkeys. All animals subjected to serial ablation of the middle third of sulcus principalis were found to be capable of reacquiring preoperative levels of performance on the task. However, one-stage removal of the mid-principalis region resulted in both more severe and more protracted impairments than were evident after serial surgery. These results in conjunction with previous findings suggest that recovery following serially induced neurological insult may be dependent upon the integrity of neural tissue adjacent to the locus of injury.
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Although the entorhinal cortex is a major contributor of afferents to the hippocampus and dentate gyrus, knowledge of its own afferents has been vague. Regions of both the frontal and temporal lobes were found to contribute afferents to this region of the brain. These afferents form probable multisynaptic links in pathways connecting the classical sensory areas of the cortex and the limbic system.
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