Streptomycin and isoniazid metabolism in malnourished children.
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Child↗
Biomedical subjects
N Buchanan
Publications and source records attributed to N Buchanan.
The binding of chloroquine to normal and Kwashiorkor serum.
The binding of chloroquine to kwashiorkor and normal serum was investigated. The results show that more drug is bound in kwashiorkor serum, and that this occurs predominantly at the gamma globulin fraction. Therapeutically, in malnutrition there is no significant abnormality of protein binding with respect to chloroquine.
Alpha-Globulins↗
Is intensive care a stressful occupation?
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Humans↗
Problems in prescribing for ambulatory Black adults.
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Adult↗
Prolonged induced hypertension in the management of incipient cerebral infarction.
A patient operated upon for a carotico-cavernous fistula developed incipient cerebral infarction. Metaraminol was used for a period of eight days to produce a therapeutic elevation in blood pressure to prevent this complication. Its possible role in the management of similar complications in the post-operative period of intracranial aneurysms and post angiography is discussed.
Arteriovenous Fistula↗
Hypoglycaemia associated with severe kwashiorkor.
A study was designed to investigate the hypoglycaemia of severe kwashiorkor. The findings of significant stores of hepatic glycogen suggests that glycogenolysis was impaired. Plasma glucagon levels were relatively low, and it is suggested that this might be secondary to either a pancreatic alpha-cell defect, or inadequate sympathetic stimulation.
Blood Glucose↗
Poisoning associated with witchdoctor attendance.
Eight patients with poisoning associated with treatment by a witchdoctor are presented. Six patients died. A therapeutic approach to the problem is suggested.
Adult↗
Granulomatous glomerulonephritis and fulminant polyarteritis nodosa in a child.
The clinical and histological findings in a 12-year-old Black child with microscopic polyarteritis nodosa are presented. Particular attention is drawn to the unusual appearance of granulomatous glomerulonephritis.
Child↗
Phenolphthalein poisoning: a case report.
A case of severe poisoning due to the ingestion of phenolphthalein in the form of a patent medication, is described.
Adult↗
Intensive care in a hospital for Blacks. A review of 300 consecutive admissions.
Experinece with the first 300 patients in a new Intensive Care Unit for Blacks is presented. Causes of death and specific problems are considered in detail.
Acidosis↗
Isoniazid inactivation in Black patients with tuberculosis.
A 27% incidence of slow INH inactivator (acetylator) status was observed in a group of 100 Black tuberculotic patients. It is suggested that the incidence of INH toxicity may be high in this group of patients and that clinical cognisance of this problem is desirable.
Acetylation↗
Pharmacology of malnutrition III: binding of digoxin to normal and kwashiorkor serum.
Digoxin binding to normal and kwashiorkor serum was studied and found to be inferior in the latter. Digoxin should be used with care in hypoalbuminemic patients.
Blood Proteins↗
Studies in cerebrospinal acid base values in intensive care patients.
CSF acid base homeostasis was studied in 22 patients in an Intensive Care Unit, to ascertain whether an assessment of this parameter was of any prognostic value. The only significant findings were a lower CSF bicarbonate concentration in those patients who demised, as well as a poor correlation between CSF pH and both CSF PCO2 and bicarbonate. It was concluded that an assessment of CSF acid base balance was of no prognostic value in this particular group of patients.
Acid-Base Equilibrium↗
The management of septic abortion in an intensive care unit.
The value of ICU treatment in the management of septic abortion has been assessed. Of patients subjected to hysterectomy, the mortality is now 20%, as opposed to 37% prior to the advent of ICU. It would therefore appear that these patients can benefit from intensive nursing and medical attention.
Abortion, Septic↗
Organic acidaemia in intensive care unit patients.
Forty ICU patients were studied as to the prevalence and importance of organic acidaemia. It was observed that organic acidaemia was extremely common, secondly that a persistence of such an acidaemia heralded a poor prognosis and finally that the acidaemia rarely needed treatment in its own right.
Acidosis↗
Letter to the editor: Chloramphenicol metabolism in children with PCM.
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Adult↗
Isoniazid pharmacokinetics in patients in chronic renal failure.
INH pharmcokinetics was studied in 2 groups of patients in chronic renal failure. In the group on conservative treatment, INH half life was prolonged, but was not related to the degree on renal impairement. In the hemodialysis group 73% of the INH given was removed by dialysis within 5 hours. If INH is to be used in the presence of renal failure, individual half life estimations should be performed in order to determine dosage frequency. In patients on hemodialysis, therapy should be given post dialysis. Alternatively, drugs not dependent on renal failure, e.g. rifampicin, may be preferable.
Adult↗
Malnutrition: Food for thought.
It has been suggested that the majority of malnourished persons do not represent a medical problem. They are afflicted by socio-economic disease and the onus is on society to provide the cure which should be economic and organisational, and which would best be co-ordinated by a small group of medical personnel with an interest in the problem.
Attitude to Health↗