Search PubMed⌕ Search

Biomedical subjects

N Breslau

Publications and source records attributed to N Breslau.

At least 73 records · Page 4Linked to original sources

Maternal smoking among blacks and whites.

Data from a random sample of mothers and children participating in a study on the sequelae of low birth weight were used to examine potential risk factors of maternal smoking. It was hypothesized that maternal smoking will vary by race, age, education, psychiatric status, employment status, single mother status and indicators of the burden of child care. Low education, young age, current psychiatric disorder and having a child with a psychiatric disorder or a physical illness predicted maternal smoking. The association of maternal smoking with other factors, specifically maternal employment and indicators of the burden of child care, varied between blacks and whites. Single mother status and having pre-school children in the home was associated with a higher odds ratio for smoking in whites, but not in blacks. On the other hand, maternal employment was associated with a lower odds ratio for smoking in blacks only. This study identified common and race-specific predictors of smoking in white and black mothers. It emphasizes the need for a greater understanding of the social context of maternal smoking in different ethnic populations, and highlights the importance of the burden of child care as a factor in maternal smoking.

Black or African American↗

Migraine: association with personality characteristics and psychopathology.

The relationship between migraine and psychopathology has been discussed far more often than it has been systematically studied. Twentieth-century investigators have frequently described the obsessional rigid, angry personality postulated to characterize migraine sufferers. More recent population-based studies have demonstrated associations between migraine and depression and migraine and panic disorder. This article discusses the relationship of migraine and personality and migraine and psychopathology.

Controlled Clinical Trials as Topic↗

Risk factors for PTSD-related traumatic events: a prospective analysis.

OBJECTIVE: The authors previously identified suspected risk factors for traumatic events related to posttraumatic stress disorder (PTSD) on the basis of data gathered retrospectively. In this study, they tested that model prospectively. METHOD: A random sample of 1,200 persons was drawn from all 21- to 30-year-old members of a large health maintenance organization. In 1989, 1,007 of these persons were interviewed, and suspected risk factors were measured. In 1992, 979 were reinterviewed, and the 3-year incidence of exposure to traumatic events was ascertained. RESULTS: Nineteen percent of the sample reported traumatic events during the 3-year follow-up. A history of past exposure to traumatic events signaled an increase in the liability to exposure during follow-up, independent of suspected risk factors. Two predictors of exposure, neuroticism and extroversion, identified retrospectively, also predicted exposure prospectively. The odds for exposure among males and persons with less than a college education were marginally significant. Early misconduct and a family history of psychiatric disorder-predictors of exposure in the retrospective data-were not significant predictors at 3-year follow-up. Blacks had a higher incidence of exposure during follow-up than whites. An exploratory reanalysis suggested that the discrepancy between the retrospective and prospective results may be explained by the inclusion of childhood exposure in the lifetime retrospective inquiry. CONCLUSIONS: The assumption that PTSD-related traumatic events are random phenomena was unsupported. Among young adults, those with less education, blacks, and those with high neuroticism and extroversion scores are more likely than others to be exposed to traumatic events and are thus at greater risk for PTSD.

Adult↗

A gradient relationship between low birth weight and IQ at age 6 years.

OBJECTIVE: To test for a suspected adverse effect of low birth weight (< or = 2500 g) on IQ at age 6 years in two socioeconomically disparate populations. DESIGN: Nonconcurrent prospective study. SETTING: An urban, predominantly disadvantaged population and a suburban middle-class population in southeastern Michigan. PARTICIPANTS: Low-birth-weight (N = 473) and normal-birth-weight (N = 350) subjects, randomly selected from the 1983 through the 1985 newborn lists of two major hospitals, one serving an urban and the other a suburban population. MAIN OUTCOME MEASURES: The Wechsler Intelligence Scale for Children-Revised to measure IQ. RESULTS: The mean full-scale IQ of low-birth-weight children was 4.9 points lower than that of normal-birth-weight children, controlling for population site, maternal IQ, maternal education, and race (95% confidence interval [CI], 3.0 to 6.8). There was no evidence of low-birth-weight interaction with population site, and the same IQ difference was detected in both populations. In the urban population, low birth weight was associated with an increased risk for IQ below 85 (odds ratio, 2.2; 95% CI, 1.3 to 3.7). In the suburban population, low birth weight was associated with an increased risk for IQ below 100 (odds ratio, 2.0; 95% CI, 1.2 to 3.4). A gradient relationship with full-scale IQ was observed, with the largest deficit in those born weighing 1500 g or less, an intermediate deficit in those born weighing 1501 through 2000 g, and the least pronounced deficit in those born weighing 2001 through 2500 g. CONCLUSIONS: The overall effect of low birth weight represents an increase of approximately 10% of low-birth-weight children with an IQ of more than 1 SD below the population's mean. Children born weighing 2000 g or less bore the major burden of the IQ deficits.

Child↗

DSM-III-R nicotine dependence in young adults: prevalence, correlates and associated psychiatric disorders.

We describe the epidemiology of nicotine dependence and its association with other substance use and psychiatric disorders. Data came from a random sample of young adults, 21-30 years of age, in the Detroit, Michigan metropolitan area. The NIMH Diagnostic Interview Schedule was used to ascertain DSM-III-R disorders. Lifetime prevalence of nicotine dependence was 20%. Higher rates were observed in whites, persons with low education and persons who were separated or divorced. Males and females with nicotine dependence had significantly increased odds for alcohol and illicit drug disorders, major depression and one or more anxiety disorder, as compared to non-dependent smokers and non-smokers combined. Among smokers, lifetime prevalence of illicit drug disorders other than marijuana alone, major depression and any anxiety disorder were significantly higher in dependent than non-dependent people. Major depression was associated specifically with nicotine dependence, an association explained in part by neuroticism. This finding suggests that the personality trait of neuroticism might constitute a common predisposition for major depression and nicotine dependence.

Adult↗

Post-traumatic stress disorder in victims of civilian trauma and criminal violence.

Many individuals in the community suffer from PTSD and other stress reactions. Physicians, however, tend to diagnose post-traumatic symptoms as anxiety or depressive disorders rather than PTSD. Contacting and engaging patients after a disaster can be quite difficult. The chronic PTSD patient has been described as elusive and difficult to detect within the health care system. In one study, the time interval from trauma to psychiatric consultation was well over 3 years. A history of PTSD is often obscured by comorbid disorders or adjustment difficulties, such as depression, aggressive behavior, and drug and alcohol abuse. PTSD is a common problem, particularly in populations that are at high risk for exposure to traumatic events, such as the homeless, drug abusers, and those of specific professions. Although research on treatment of PTSD has revealed only modest benefits, early detection and intervention are important and might prevent poor adjustment and a chronic outcome. Clinicians should routinely inquire about history of unpleasant events and distasteful and unspeakable experiences, both recent and lifetime. Studies of various traumatic events consistently demonstrated that the presence of significant symptoms between 6 weeks to 6 months after exposure predicts chronic PTSD. Although early intervention might lead to the prevention of PTSD or its chronic course, there have been no randomized or controlled studies to support this hypothesis. Research on PTSD in victims of civilian trauma has only recently begun. Rape is the most extensively studied civilian trauma. Most studies reported that PTSD following rape is common. Further, characteristics of the rape event, such as rape by a stranger, use of physical force, display of weapons, and victim injury, are associated with a greater likelihood of PTSD, and symptoms at 3 months after the rape are predictive of a chronic course. Interest in the consequences of MVAs has increased dramatically, perhaps owing to the frequency of such accidents and the large number of PTSD damage claims. There is a great need to understand work environments better and the special risks associated with dangerous occupations, such as police, firefighters, rescue workers, and body handlers. Clinicians commonly attribute symptoms to a particular stressor, usually the most recent stressor or the stressor that represents the content of the symptoms. For example, nightmares about a recent auto accident and avoidance of expressways are interpreted as evidence that a recent auto accident is the cause of PTSD symptoms.(ABSTRACT TRUNCATED AT 400 WORDS)

Chronic Disease↗

Comorbidity of migraine and major affective disorders.

Two epidemiologic studies of young adults from the Detroit metropolitan area and from Zurich, Switzerland, focused on the relationship between migraine and affective disorders, such as major depression, dysthymia, bipolar disorder, and cyclothymia. Through application of current definitions of migraine and psychiatric disorders in structured diagnostic interviews, data have been obtained that strongly support clinical observations on migraine-major depression comorbidity. The findings to support a link between migraine and bipolar disorder are less consistent. Physicians caring for patients with migraine or affective disorders should maintain diagnostic vigilance for comorbid disease and, when present, should consider comorbidity in planning treatment interventions.

Adult↗

Comorbidity of migraine and panic disorder.

Clinical and epidemiologic evidence suggests that migraine co-occurs with psychopathology, including specific anxiety disorders. To examine this association, survey data from a population-based study of more than 10,000 respondents were used to determine if individuals with a history of panic attacks were at greater risk of having specific headaches in the week preceding an interview. Four types of headache were defined. Of these, only migraine was strongly associated with panic attacks. Given the high prevalence of both migraine and panic attacks and evidence that they often co-occur, treatment implications are discussed for this comorbidity.

Adolescent↗

Nicotine dependence and major depression. New evidence from a prospective investigation.

We examined prospectively the association between nicotine dependence and major depression (MDD). The following questions were addressed: (1) Are smokers with a history of MDD at increased risk for progression to nicotine dependence and more severe levels of dependence? (2) Are persons with a history of nicotine dependence at increased risk for MDD? A sample of 995 young adults were interviewed in 1989 and reinterviewed in 1990, 14 months later. The revised National Institute of Mental Health-Diagnostic Interview Schedule was used to ascertain DSM-III-R nicotine dependence and other substance use and psychiatric disorders. A history of MDD increased the risk for progression to nicotine dependence or more severe levels of dependence (odds ratio, 2.06; 95% confidence interval, 1.21 to 3.49). In addition, persons with a history of nicotine dependence had a higher rate of first-incidence MDD during the follow-up period than persons with no history of nicotine dependence (7.5% vs 3.2%; odds ratio, 2.45; 95% confidence interval, 1.17 to 5.15). The prospective data suggest that the association between nicotine dependence and MDD, observed previously in cross-sectional studies, might be either causal, with influences flowing in both directions, or, more probably, noncausal, reflecting the effects of common factors that predispose to both disorders.

Adult↗

Smoking and nicotine dependence in young adults: differences between blacks and whites.

Analysis of data from a household interview of young adults in Michigan was conducted to determine the prevalence of smoking and nicotine dependence and to examine the relationship of nicotine dependence with health indicators in black and white smokers. The NIMH Diagnostic Interview Schedule, revised to cover DSM-III-R diagnoses, was used to assess nicotine dependence. A greater proportion of whites than blacks tried smoking, became regular smokers and met criteria for nicotine dependence. Whites had their first cigarette, began smoking regularly and manifested symptoms of nicotine dependence at a younger age than blacks. Nicotine dependence, rather than smoking per se, was associated with poor physical and psychological health among both blacks and whites. However, it had stronger associations with health problems in blacks than in whites.

Adult↗

Early smoking initiation and nicotine dependence in a cohort of young adults.

We examined the extent to which nicotine dependence and daily smoking might vary by age at first cigarette. The potential confounding effects of sex, race and history of childhood behaviour problems were examined as well. A sample of 1200 was randomly selected from the subset of 21-30-year-old members of a large HMO in the Detroit SMSA; 1007 (84%) agreed to participate. Personal interviews were conducted in respondents' homes, using the NIMH-DIS to elicit information on DSM-III-R diagnoses, including nicotine dependence. Controlling for sex and race, persons who smoked their first cigarette at 14 to 16 years of age were 1.6 times more likely to become dependent than those who initiated smoking at an older age (P = 0.03). The association was unchanged when history of childhood behaviour problems was also controlled. Smoking initiation before age 14 was not associated with increased probability of dependence. Persons who initiated smoking before age 14 had a longer lag time to daily smoking and a lower likelihood of progressing to daily smoking, compared to persons who initiated smoking later on. The findings suggest that, among persons who have ever smoked, there might be two distinct groups in whom the chances of developing dependence are considerably reduced. The first comprises persons who delayed first use until age 17. The second comprises persons who smoked their first cigarette before age 14, a group in whom the progression to daily smoking might be markedly slower than in persons who initiated smoking when they were older.

Adolescent↗

Daily cigarette consumption in early adulthood: age of smoking initiation and duration of smoking.

This study considers the extent to which daily consumption of cigarettes in young adults varies by age at first cigarette and duration of smoking. Data come from a random sample of 21- to 30-year-old members of a large HMO in the Detroit area. Daily cigarette consumption by current smokers varied by duration of daily smoking: the longer the duration, the higher the number of cigarettes smoked. Duration from first cigarette to daily smoking bore no relationship to cigarette consumption. When duration of daily smoking was statistically controlled, the association between cigarette consumption and age at first cigarette was not statistically significant. The findings suggest that public health efforts to delay daily smoking among adolescents might reduce cigarette consumption in early adulthood.

Adult↗

Health of very low birth weight children during their first eight years.

To determine the impact of very low birth weight (VLBW) on medical outcomes during childhood, we compared the health of 249 VLBW children born from 1977 through 1979 with that of 363 normal birth weight (NBW) control children at 8 years of age. Measures included the rates of specific illnesses, surgical procedures and accidents, growth, and other physical findings. The number of medical conditions and surgical procedures was significantly greater in the VLBW children than in the NBW control children. Eighteen percent of VLBW versus 5% of NBW children had had respiratory conditions (p < 0.001), mainly before 3 years of age. Surgical procedures were more common both before and after 3 years of age, but accidents occurred with similar frequency. The VLBW children had significantly lower weight, height, and head circumference and more minor physical stigmata. Thus medical illness, surgical interventions, and poor growth attainment are part of the ongoing morbidity of VLBW children during childhood.

Accidents↗

Vulnerability to psychopathology in nicotine-dependent smokers: an epidemiologic study of young adults.

OBJECTIVE: In a previous article the authors reported associations between nicotine dependence and psychiatric disorders in a community sample of young adults. Increased lifetime rates of major depression and anxiety disorders were found in persons with DSM-III-R nicotine dependence but not in nondependent smokers. The purpose of the present study was to examine the associations of nicotine dependence with four measures of psychologic vulnerability to nonpsychotic psychiatric disorders. METHOD: A randomly chosen group of 1,007 21- to 30-year-old members of a large health maintenance organization were interviewed with the National Institute of Mental Health Diagnostic Interview Schedule, revised for DSM-III-R diagnoses. Self-ratings of neuroticism, negative affect, hopelessness, and general emotional distress were obtained. RESULTS: Nicotine dependence, but not nondependent smoking, was associated with higher scores on all four measures of vulnerability to psychopathology. With one exception the associations between nicotine dependence and these psychologic measures remained significant when the variables current smoking status, history of major depression or anxiety disorders, alcohol and drug use disorders, race, and level of education were controlled; the association of nicotine dependence with general emotional distress was not significant. CONCLUSIONS: Neuroticism and the correlated psychologic vulnerabilities may commonly predispose to nicotine dependence and major depression or anxiety disorders.

Adult↗

Cocaine use and dependence in young adults: associated psychiatric disorders and personality traits.

Current and lifetime prevalence of substance use and psychiatric disorders was determined by administering the NIMH-DIS, revised to cover DSM-III-R diagnoses, to a sample of 1007 young adults. Personality and affectivity were measured also. Increased rate of any Substance Use Disorder was related to use of cocaine more than 5 times over the lifetime regardless of whether or not criteria for Cocaine Dependence were met. Increased rate of any Affective Disorder was related to dependence in those who used cocaine more than 5 times. Cocaine use was associated with increased neuroticism, psychoticism and negative affect.

Adult↗