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Biomedical subjects

N Battistini

Publications and source records attributed to N Battistini.

126 records · Page 7Linked to original sources
PubMedDate not supplied

The prediction of extracellular and total body water from bioelectric impedance in a non-Caucasian population from central Asia.

The availability of only a small number of studies on bioelectric impedance analysis (BIA) in non-Caucasian ethnic groups appears to limit reliable utilization of this method in anthropological field studies. In this study, 28 male Turkish-Mongolian subjects native of Kazakhstan (Central Asia) underwent total body water (TBW) and extracellular water (ECW) assessment by deuterium oxide (D2O) and sodium bromide (NaBr) dilution respectively. Bioelectric impedance (BI) was recorded at multiple frequencies. ECW and TBW were calculated from BI at 1 and 100 kHz respectively by applying formulae developed on a sample of Caucasian subjects with a hydration status similar to that of the study population. TBW predicted from BI at 1 and 100 kHz (37.5 +/- 3.31) was highly correlated and not significantly different from that obtained by D2O dilution (39.0 +/- 4.11, r = 0.894, p < 0.0001, SEE = 1.91). Similarly, ECW predicted from BI at 1 kHz (15.1 +/- 1.21) was highly correlated and not significantly different from that obtained by NaBr dilution (15.0 +/- 1.61, r = 0.847, p < 0.0001, SEE = 0.81). It is concluded that selected predictive formulae developed on Caucasian subjects may provide a precise and accurate assessment of ECW and TBW in Turkish-Mongolian populations.

Adult↗
PubMedDate not supplied

Body water distribution in highlanders versus lowlanders.

Acute exposure to high altitude produces characteristic changes in body water distribution from which acclimatized individuals seem to be spared. However, it has been suggested that body water distribution may be different in highlanders (HL) as compared to lowlanders (LL). We studied the distribution of total body water (TBW) between extracellular water (ECW) and intracellular water (ICW) in a group of 20 HL (3200 m above sea level) versus one of 20 LL (900 m above sea level). Subjects were matched for ethnic group (Kirghiz), sex (male), weight (Wt), height and body mass index. TBW:Wt and ECW:TBW were not different in HL as compared to LL (mean +/- SD, 58.5 +/- 5.0% versus 56.0 +/- 4.2% and 40.5 +/- 4.2% versus 40.7 +/- 2.2%; p = n.s. for both). This study does not support the hypothesis that body water distribution is different in HL as compared to LL.

Adult↗
PubMedDate not supplied

Anthropometry fails in classifying bone mineral status in postmenopausal women.

This study tested two hypotheses: (1) that simple anthropometric parameters can be used to identify patients at risk of decreased bone mineral content and (2) that an inverse relationship exists between waist:hip ratio (WHR) and bone mineral density (BMD). Bone mineral content (BMC) and BMD were evaluated by dual-energy X-ray absorptiometry in 1873 free-living women. Of these, 1819 (97%) were post-menopausal. One thousand and thirteen women (54%) had normal BMD, 705 (38%) osteopenia and 155 (8%) osteoporosis. Body weight (Wt), body mass index and arm muscle and fat areas were significantly lower in osteoporotics than osteopenics (p < 0.0001) and in these latter than controls (p < 0.0001). However, values of WHR were similar in all groups (p = ns). Body weight was the anthropometric parameter better correlated with BMC (rho = 0.650, p < 0.0001) and only Wt and age were identified as significant predictors of bone mineral status (normal-BMD/osteopenic/osteoporotic) at polytomous logistic regression (p = 0.0001 for each). However, Wt could not be employed as an indicator of bone mineral status at the individual level because of high variations in BMC for the same level of Wt. Under- (< 5th percentile) and normal-Wt (5th-95th percentile) women had the same frequency of osteopenia (39%) while it was lower in over-Wt (> 95th) women (13%). The frequency of osteoporosis was higher in under- than normal-Wt women (37 vs 7%) and none of the over-Wt women had osteoporosis. This study shows that: (1) simple anthropometric measurements cannot be used to select subjects at risk of decreased BMC and, (2) BMD does not vary with WHR.

Absorptiometry, Photon↗
PubMedDate not supplied

Quantitative EEG mapping, regional cerebral blood flow, and neuropsychological function in Alzheimer's disease.

The relations between quantitative EEG, regional cerebral blood flow (rCBF), severity of disease and neuropsychological data were analyzed in 31 patients in different stages of Alzheimer's disease (AD). As a group the demented patients had higher delta and theta activities, lower alpha activity and lower alpha peak frequency than control subjects. rCBF was reduced in all regions studied but mainly in the temporoparietal areas. An analysis of correlations showed a close relationship between rCBF and certain quantitative EEG parameters in AD patients, mainly the power of the theta and delta bands. Both rCBF evaluation and quantitative EEG provide functional information related to the severity of cognitive impairment.

Aged↗
PubMedDate not supplied

Platelet embolism in rabbit brain.

Transient cerebral ischemia was induced in rabbits by selective infusion of arachidonic acid (0.35 mg/kg in 15 sec) into the internal carotid artery. Platelet emboli caused transient ischemia of the brain, reaching a maximum within a few seconds after injection. After embolism the EEG flattened, blood flow stopped in almost the entire injected hemisphere, cortical pH gradually fell from 7.31 +/- 0.09 to 7.05 +/- 0.10 and cortical K+ activity rose from 4.7 +/- 1.8 to 12.7 +/- 6.4 mmol/kg H2O. Complete ischemia lasted 3-5 min; then cerebral circulation was gradually restored without reactive hyperemia. Forty-five min after embolization, circulation had been resumed in almost the entire injected hemisphere, whereas metabolic changes were still disturbed. Eighty percent of the animals recovered complete neurological function and 20% showed permanent damage confirmed by histological examination after 1 week of recovery.

Animals↗
PubMedDate not supplied

Animal model of TIA: an experimental study with intracarotid ADP infusion in rabbits.

Adenosine diphosphate (8 mg per minute for five minutes) was infused into the carotid artery of 63 rabbits. The effects were twofold: systemic hypotension and platelet aggregation in the cerebral circulation. As a consequence of the last effect, platelet emboli were produced which occluded cerebral arteries in a number and size sufficient to cause cerebral ischemia. Areas of focal ischemia were observed through a cranial window, and documented with antipyrine autoradiography. Platelet thrombi were almost entirely transient, being fragmented and removed within a very short time of cessation of ADP infusion. Consequently, no permanent tissue damage ensued. This experimental model approaches the spontaneous transient ischemia attacks (TIAs) in man, demonstrating that these can be caused by pure platelet emboli. A high cholesterol diet administered for two months prior to ADP infusion did not enhance the effect of the procedure or make the platelet aggregation and the following ischemia longer in duration or more severe.

Adenosine Diphosphate↗
PubMedDate not supplied

[CAT and MRI in the study of partial epilepsy: comparison of the 2 methods and correlations with EEG].

Seventy five adult patients suffering from partial epilepsy were investigated by MRI. Results were then compared with those obtained with CT scan and EEG analysis. The interval between the two neuroradiological studies did not exceed five years. MRI and CT showed abnormalities respectively in 45 and 55% of patients, MRI showed a better sensitivity in detecting ischemic or atrophy-gliosis chronic focal alterations. In the remaining lesions such as tumors, vascular malformations, cysts and diffuse atrophies, where often an urgent diagnosis is necessary, both tests were equally sensitive. EEG showed alterations in 80% of patients and agreed with results of CT scan and MRI in about 80% of cases.

Adolescent↗
PubMedDate not supplied

[Maps of somatosensory evoked potentials from the arm in patients with neoplasms and post-traumatic brain lesions].

Short-latency somatosensory evoked potentials by the stimulation of the median nerve at the wrist, were recorded in six patients (four with cerebral tumors and two with post-trauma lesions). The electrodes were placed on the scalp following the 10-20 International System. A reference electrode was placed on earlobe contralateral to the site of the stimulation. Eleven normal subjects were used as control (mean age 64.4 +/- 12.05). We used the Brain-Surveyor-Basis Trade system which allowed us to elaborate the results by coloured mapping through linear interpolation of signal amplitudes. The following parameters were investigated: peak latencies of the N13, N20, P22, N30 waves; amplitudes of the post-rolandic P14-N20, N20-P25, pre-rolandic P22-N30 components and the central conduction time N13-N20 (CCT). The evaluation of latencies was not significant in determining the lesion site. On the contrary, the evaluation of amplitudes revealed expressive asymmetry, though it did not define the nature of alteration (increase or decrease due to lesion), and the correlation between these variations and the site of the lesion. The authors discussed the possibility that amplitude abnormalities in patients with tumors were related either to the tumors and/or drug effects.

Adult↗
PubMedDate not supplied

[Palm stimulation in carpal tunnel syndrome].

In order to verify the sensory nerve conduction velocity (SNCV) by median nerve palmar stimulation regard to each single finger, we tested 48 patients with typical CTS symptoms, confirmed by neurophysiological examination. The control group consisted of twenty-seven healthy volunteers, of similar mean age. The SNCVs were obtained by stimulating the II finger (M2), III (M3), IV (M4) and II and III intermetacarpo-phalangeal site (respectively P2 and P3) for median nerve; IV finger (U4) and IV intermetacarpophalangeal site (P4) for ulnar nerve. Data show that P2 was normal in 3 cases (6.2%), as was M2; M3 in 2 cases (4.2%) and P3 only in one case (2.1%). No sensory nerve action potential was recorded in 3 case (6.2%) during P3 stimulation, in comparison to 14 cases (29.2%) during M4 stimulation. When each case was examined separately, the behaviour of palmar SNCV resulted similar to the corresponding fingers. Finally, the ratio between SNCV values of P2/P3, with respect to controls, showed a further more severe damage of P3 compared to the P2, generally preferred by other authors.

Action Potentials↗
PubMedDate not supplied

[Memory changes in herpes virus encephalitis: report of a case].

A case of Herpes Simplex Encephalitis with a benign course was present in a 66-year-old patient. A year after the acute phase of the illness, the patient continued to suffer from inability to fix verbal material in memory. During the acute phase, cerebral NMR revealed a large evolving lesion in the right temporal region, and an old lesion located in the same region of the opposite hemisphere. From the medical history, we learned that the patient, 35 years earlier, suffered a similar episode, including a short-term memory deficit. In the following study, we will discuss this case report in relation to data found in the literature dealing with memory deficit, caused by mono and bilateral, temporal lesions.

Aged↗
PubMedDate not supplied

[A case of cerebral angioma: non-invasive instrumental diagnosis].

A case of cerebral angioma: non-invasive assessments. A 65-year-old woman, suffering from epileptic seizures since the age of 6, was examined. Transcranial Doppler (TCD) ultrasounds, SEPs and EEG brain mapping by means of median nerve stimulation, were performed, followed by a NMR of the brain, which revealed an arteriovenous malformation in the left hemisphere (frontal and parietal lobe). By comparing the results of the neurophysiological tests, the diagnostic value of TCD, confirmed by the neuroradiologic findings, was established. EEG and SEPs were also abnormal, but their actual effectiveness in clinical studies is discussed. We conclude that these electrophysiological examinations do not allow a reliable diagnosis as with TCD.

Aged↗
PubMedDate not supplied

Influence of aging on the neurochemical organization of the rat paraventricular nucleus.

The paraventricular nucleus (PVH) of the hypothalamus is a key region for the integration of the autonomic and neuroendocrine mechanisms. This integration becomes less reliable with age. Some critical functions, such as eating and drinking, body-temperature regulation, autonomic and endocrine responses which regulate the cardiovascular system seem to be particularly affected by the aging-related processes. In this paper, we analysed by means of immunocytochemistry the neurochemical organization of the magnocellular and parvocellular component of the PVH in old male rats. The main results concerning the neurohormones and the carrier proteins are the following: a significant decrease in the number of the oxytocin- (OXY) like immunoreactive neurons of the medial and lateral parvocellular nuclei; a decrease in the vasopressin- (VAS) like immunoreactive neurons of the medial and lateral parvocellular nuclei and also of the medial magnocellular nucleus; a decrease in the neurophysin- (NRP) like immunoreactive neurons of the lateral parvocellular nucleus. We also found a decrease in the mean area of magnocellular OXY- and VAS-like immunoreactive neurons, a decrease in the extension of the dendritic tree sampled in the medial part of the nucleus; a decrease in the number of varicosities along the neurons coming from the PVH, and in the density of axons in the median eminence and in the vagal complex. The NRP-like immunoreactive structures in the substantia gelatinosa of the spinal cord of old rats were also decreased in respect to younger adult animals. Among the neuropeptides investigated (corticotropin-releasing factor, leu-enkephalin, somatostatin, cholecystokinin and neurotensin) we found a decrease in the leu-enkephalin-like immunoreactive neurons of the dorsal and medial parvocellular nuclei. Our data support--from a morphological point of view--the existence of involution processes in the neurochemical organization of the PVH during aging.

Aging↗