Allergy to chemical solutions for soft contact lenses.
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Biomedical subjects
Publications and source records attributed to N B Pedersen.
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Two patients with cutaneous alternaria infection are presented. In both patients the skin lesions were characterized by multiple non-healing ulcers covered with dry crusts. Although the skin changes were macroscopically alike in the two patients, differences in the histology were seen. Both patients had primary debilitating diseases. A review of the literature is presented and revealed an additional ten cases of cutaneous alternariosis. Methods for the isolation of Alternaria and the susceptibility of the fungus to antimycotic drugs are presented.
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Two male employees in an industry producing plastic emulsions acquired contact dermatitis from preservatives. One was sensitized to both components in a preservative, i.e. 1,2-benzisothiazolin-3-one and ethylene diamine. The other man acquired a contact allergy to 1,2-benzisothiazolin-3-one and to another preservative, formaldehyde.
Two cases of necrolytic migratory erythema are described. Both patients also suffered from anaemia, weight loss, hypersedimentation and carbohydrate intolerance. A solitary pancreatic tumour was found in both cases-- at autopsy in one and at laparotomy in the other. Microscopic examination of skin biopsies showed necrolysis of superficial epidermis. Both patients had extremely elevated plasma concentrations of pancreatic glucagon. By means of specific staining and immunofluorescence techniques the tumours were shown to consist of glucagon-containing alpha2-cells. It is concluded that these patients suffered from the newly described glucagonoma syndrome.
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