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Biomedical subjects

N B Egorova

Publications and source records attributed to N B Egorova.

At least 37 records · Page 2Linked to original sources
PubMed1982

[Immunostimulating activity of antigenic complexes isolated from various Staphylococcus strains].

The study of the immunostimulating potency of the staphylococcal antigenic complex obtained from different strains by aqueous extraction indicated that the preparations obtained from highly virulent strains showed the lowest potency after challenge with both homologous and heterologous strains. The preparations obtained from strains with low virulence stimulated resistance to highly virulent strains to a greater extent than the preparations from the same virulent strain which was used for challenge. The necessity of revising the requirements to strains used for the production of antibacterial staphylococcal preparations is substantiated.

Animals↗
PubMed1981

[Experimental study of the protective activity of a complex staphylococcal antigen and toxoid when administered in combination].

The data obtained in the experimental study of the protective activity of an antigenic staphylococcal complex prepared by the method of aqueous extraction and staphylococcal toxoid (native and adsorbed) are presented. The study carried out on the model of septic staphylococcal infection in rabbits indicated that after immunization with the mixture of the above-mentioned preparations the survival time of the rabbits increased to a greater extent than after immunization with each of these preparations separately. This regularity was especially pronounced under the aggravated conditions of infection with the mixture of strains.

Animals↗
PubMed1978

[Toxicity and the protective activity of a complex staphylococcal antigen obtained by water extraction].

The toxicity and the protective activity of a complex staphyloccus antigen was studied. Its insignificant toxicity for mice when injected intraperitoneally and protective activity under conditons of experimental infection on mice, rabbits, and guinea pigs were demonstrated. In particular it was shown that the antigen obtained in doses under study protected rabbits from septic staphylococcus infection more than antitoxin and corpuscular vaccine. Under conditons of local experimental infection on mice the complex antigen promoted a more rapid than corpuscular vaccine elimination of the local focus of infection.

Animals↗
PubMed1976

[Participation of the lungs in the formation of an immune response].

The process of accumulation of the antibody-forming cells (AFC) in the lungs after vaccination of rabbits with the typhoid antigen was studied. No AFC was revealed in the lungs after single aerosol and subcutaneous immunization; double administration of the antigen through the respiratory tracts was followed by significant AFC accumulation in the lung tissue; individual antibody-synthesizing cells were found in the lung after subcutaneous application. Revaccination was followed by intensification of the immune response of the lung in both methods of vaccination; the content of antibody-producing cells in the aerosol-immunized rabbits was much greater than in the animals vaccinated subcutaneously. This indicated a definite role of the lungs in the immunogenesis in the case of the antigen administration through the respiratory tract.

Animals↗