II. Ultrastructural changes in focal retinal ischaemia.
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Biomedical subjects
Publications and source records attributed to N Ashton.
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A series of 34 cases of embryonal sarcoma and embryonal rhabdomyosarcoma of the orbit has been placed histologically into three groups according to their maximum degree of differentiation at any stage: (a) embryonal sarcoma, (b) non-striated embryonal rhabdomyosarcoma, and (c) striated embryonal rhabdomyosarcoma. The patients were then followed up. This paper presents a summary of the clinical course of the whole series and an account of eight typical cases; the age and sex incidence and survival rates are shown and the histology, treatment, and prognosis are discussed.
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Perhaps on such a relaxed evening as this, one might reflect on the problem more freely and recall that all living matter is vulnerable to the injurious effects of oxygen and man is certainly no exception. It is strange indeed that the element upon which our very existence depends, should at the same time be so alien, and withstood only by the antioxidant defence mechanisms our cells have elaborated. We are born into and live in a poisonous atmosphere. Growing retinal vessels die because they have not yet acquired these defences and we all age and die because, it is thought, we lose them. As Gerschman so strikingly expressed it:--"The normal life span can be considered as a survival time for the organism exposed to 0.2 atmospheres of oxygen"--and that is air at sea level.
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