Biomedical subjects

N Aoki

Publications and source records attributed to N Aoki.

At least 757 records · Page 42Linked to original sources

PubMed1975

Association of human alpha1-antitrypsin with anhydrotrypsin.

Unlike in the reaction of anhydrotrypsin and soybean trypsin inhibitor, human alpha1-antitrypsin was found not to form a complex with bovine anhydrotrypsin. This was shown using three different methods: electrophoresis, affinity chromatography on an anhydrotrypsin-coupled Sepharose column and equilibrium competitive binding assay. These results indicate the importance of the active site serine of trypsin in formation of a complex with alpha1-antitrypsin.

Animals↗

PubMed1975

Epidemiological evaluation of funduscopic findings in cerebrovascular diseases. I. Fundoscopic findings as risk factors for cerebrovascular diseases.

In order to epidemiologically clarify the relationships between the funduscopic findings and occurrence of cerebrovascular diseases, an analysis of 68 cerebral hemorrhage, 47 cerebral thrombosis and 230 controls in two rural Akabane and Asahi towns in Japan was accomplished and the results were as follows: 1. Among the fundamental funduscopic findings, irregular constriction, narrowing and retinal bleeding were high risk factors of cerebral hemorrhage in due order. Arteriolar reflex lateral displacement, irregular constriction, tapering, vertical displacement, white plaque and retinal bleeding were high risk factors of cerebral thrombosis in the order listed. Sheathing of arteriole was significantly related to the occurrence of cerebrovascular diseases. 2. Risk of cerebral hemorrhage was significant and highest in grade 3 of Scheie's hypertensive and Keith-Wagener's classifications. Grade 3 of Scheie's hypertensive and Keith-Wagener's classifications of cerebral thrombosis revealed the highest O/E ratio but was insignificant. 3. As is to be expected, the higher the grade of each funduscopic finding and the classifications of the retinal findings, the higher the risk of occurrence of cerebrovascular diseases. 4. Three or more, bright red color and large plaque shape of retinal bleeding in the upper and lower temporal areas were more indicative of future cerebrovascular diseases than in other area, and one or two, dark red color or smaller bleeding. 5. Arterial blood pressure was significantly related to the occurrence of cerebral hemorrhage and thrombosis. Albuminuria was also significantly related to the occurrence of cerebral hemorrhage, but glycosuria was not found to have an important relation to the occurrence of cerebral hemorrhage. The relationship between serum cholesterol level and cerebrovascular diseases was insignificant. 6. Systolic and diastolic blood pressure and albuminuria were more important than the funduscopic findings for prospecting the occurrence of cerebral hemorrhage, and on the contrary, the funduscopic findings were more important than systolic and diastolic blood pressure and other findings for prospecting the occurrence of cerebral thrombosis.

Adult↗

PubMed1975

Epidemiological evaluation of funduscopic findings in cerebrovascular diseases. II. A multivariate analysis of funduscopic findings.

The interrelationship of the funduscopic, physical and laboratory findings, the additional information of each funduscopic finding when physical and laboratory findings were considered simultaneously, and the relative importance of each retinal finding in the funduscopic pictures were investigated by a series of multivariate analysis for 68 cerebral hemorrhage, 47 cerebral thrombosis and 230 controls in two rural towns, Akabane and Asahi, in Japan and the results were as follows: 1. For the occurrence of cerebral hemorrhage, narrowing of arteriole and irregular constriction were especially important indicators, and retinal bleeding and lateral displacement were also valuable but less than narrowing and irregular constriction. On the other hand, for the occurrence of cerebral thrombosis, arteriolar reflex was considered as the most valuable indicator, and irregular constriction, lateral displacement and white plaque were also important but less than arteriolar reflex. 2. Narrowing of arteriole was most highly related with irregular constriction while the correlation between retinal bleeding and white plaque, and also the correlation between arteriolar reflex, vertical and lateral displacement and tapering were significant. 3. A significiant correlation among physical and laboratory findings was found only between systolic and diastolic blood pressure as far as analysed. Funduscopic findings by Scheie's hypertensive and Keith-Wagener's classifications were highly correlated with systolic and diastolic blood pressure. 4. Narrowing and irregular constriction were significantly correlated with systolic and diastolic blood pressure, and the relation between retinal bleeding and glycosuria was significant. 5. An analysis of the additional information of each funduscopic finding, when evaluated with the physical and laboratory findings simultaneously, revealed that irregular constriction, lateral displacement and narrowing gave prominent additional information for the occurrence of cerebral hemorrhage, while arteriolar reflex, lateral and vertical displacement and white plaque gave valuable information for the occurrence of cerebral thrombosis. 6. It is noteworthy from these multivariate analyses that narrowing and irregular constriction may arise from a similar pathophysiological mechanism which brings out vasoconstriction and the resultant organic changes due to hypertension. It is also noticed that arteriolar reflex and A/V crossing phenomenon may come from the different pathophysiological mechanism related to arteriosclerosis. It was stressed that detailed analyses of observer variability and evolution of funduscopic findings would be necessary.

Albuminuria↗

PubMed1975

Clinical studies on thyroidal autoantibodies.

In an attempt to clarify autoimmune nature of Grave's disease and Hashimoto's thyroiditis, thyroidal autoantibodies have been studied on 86 cases of Grave's disease, 54 cases of Hashimoto's thyroiditis, 31 cases of simple goiter, 11 cases of primary hypothyroidism a-d 22 cases of thyroid neoplasia as well as on 364 healthy subjects. Two kinds of tanned red cell hemagglutination tests were carreid out on each case. One method using refined human thyroglobulin for sensitization of sheep red cells has been found to be specifice for anti-thyroglobulin antibody and to be frequently positive in Hashimoto patients. However, in another method using human thyroidal microsomes (purified by ultracentrifugation) as sensitizing antigen, some heterogenous antibodies including anti-thyroglobulin antibody might be detected together with the antibody against the antigen proper to thyroidal micorsome (HF antigen)which is derived from hyperfunctioning thyroidal follicular cells of Grave's patients. hAnti-HF antibody is frequently detected both in Hashimoto and Grave's patients. In other thyroid diseases the titers of both thyroidal autoantibodies were generally low, though higher than in healthy subjects. The effect of aging on thyroidal autoantibodies in healthy subjects was clearly observed in females but not in males. From the results of these two test, it is possible to speculate that high=columnar and hyperfunctioning thyroidal follicular cells might exist focally in most cases of Hashimoto's thyroiditis.

Absorption↗

PubMed1975