Search PubMed⌕ Search

Biomedical subjects

N Andersson

Publications and source records attributed to N Andersson.

62 records · Page 4Linked to original sources
PubMed1982

Post-mortem study of emphysema in coalworkers and non-coalworkers.

A post-mortem survey of emphysema in coalworkers and non-coalworkers was carried out in men aged 50-70 years dying of ischaemic heart disease (IHD). It was determined that in such men selection for necropsy was similar in coalworkers and non-coalworkers. All lungs were examined in a standard way and the amounts of centrilobular and panacinar emphysema were scored on numerical scales. Emphysema in men dying of IHD was significantly more frequent in coalworkers than in non-coalworkers even after age and smoking habits were accounted for by stratification. In the coalworkers, the severity of emphysema was related to the amount of dust in simple foci in the lungs. Because both groups were selected similarly from their parent populations the relative frequency of emphysema found in this study reflects that in the whole populations of coalworkers and non-coalworkers in the study area and confirms an excess of emphysema in coalworkers. This excess is likely to be due to occupational factors.

Aged↗
PubMed1981

Allergy in laboratory animal workers.

179 people working with small laboratory animals were studied by questionnaire, lung-function tests, skin tests with common allergen extracts and extracts of the serum and urine of five animal species, and serology. 49 people had symptoms related to animal contact, most commonly rhinitis but also asthma and skin rashes. Skin reactivity to animal extracts was related to symptoms, particularly asthma, but many people with rhinitis only had negative skin tests. Positive skin tests without symptoms were rare. 3 people had additional late skin reactions. Atopic individuals were no more likely than non-atopics to have animal-related symptoms but were more likely to have asthma. Gel diffusion revealed no precipitating antibodies, and no specific IgG was detected with the ELISA technique. Lung-function measurements were normal. Sensitisation to laboratory animals may involve heavy antigen exposure, so that relatively unreactive individuals can be affected. Exclusion of atopic individuals from work with laboratory animals will not eliminate the problem.

Animals↗
PubMed1979

Is appendicitis familial?

A family history of appendicectomy was sought in two groups of children admitted to Llandough Hospital over sixteen months. The study group consisted of 29 children with histologically confirmed acute appendicitis, while the control group consisted of 29 children admitted for reasons unrelated to abdominal pain. A history of appendicectomy was elicited in first-degree relatives--that is, siblings and parents of 20 of the children in the study group and of four of the controls--a statistically significant difference. The results obtained from this study suggest that a familial predisposition to appendicitis exists.

Acute Disease↗
PubMedDate not supplied

Simplification of the polymerase chain reaction for detection of Mycobacterium tuberculosis in the tropics.

It has been suggested that the technical complexities, the expense of equipment and consumables, and problems associated with contamination make the polymerase chain reaction (PCR) inappropriate for use in developing countries. These problems were addressed using a novel one-tube nested PCR, small reaction volumes and a 'three room' system for the detection of Mycobacterium tuberculosis. The PCR of sputum samples dried on small filter paper disks was also investigated. Using this strategy 5 smear-positive and 15 smear-negative specimens were correctly identified by PCR. This method of sample collection has the advantage that samples can be sent by post and stored in a minimum of space, and remain viable for PCR for at least 4 years after collection. These and future modifications to the PCR protocol will make the assay more suitable for use in the tropics.

Base Sequence↗
PubMedDate not supplied

[Epidemiologic monitoring and decentralized planification: the use of sentinel sites in Guerrero].

With the current decentralization of health care in the Mexican state of Guerrero, there is need for detailed but inexpensive information for the planning of health services. A cyclical process of measurement is proposed using sentinel sites, characterized as places of concentration of measurement resources, which are not special intervention areas or health facilities. The sites in Guerrero were selected to be representative of the health conditions in the state. During the first two years, study cycles were carried out regarding acute respiratory infections and diarrhoeas in infants, the risk factors associated with these afflictions and the attention paid to them within the community. Later cycles focussed on the importance of scorpion stings and Chagas' disease, the impact of measles vaccination and the prevalence of tuberculosis. Three types of community-based data are considered in each cycle, to optimize their use in planning (impact, coverage and costs) which, in summary formats, facilitate rapid analysis and presentation.

Child, Preschool↗