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Biomedical subjects

N Agarwal

Publications and source records attributed to N Agarwal.

247 records · Page 14Linked to original sources
PubMedDate not supplied

Diabetic retinopathy: a clinical study with special reference to fluorescein angiography.

The present study was conducted on 25 patients with Diabetes Mellitus (DM) having positive indication of diabetic retinopathy on ophthalmoscopic examination. The patients were examined clinically, ophthalmoscopically and with Fluorescein Angiography (FA). It was found that the maximum number of patients with retinopathy were in their 5th and 6th decade and that retinopathy was more common in Non Insulin dependent diabetics (NIDDM) than Insulin dependent Diabetics (IDDM). It was also seen that retinopathy takes longer time to develop in IDDM patients (16.37 years vs 11.7 years). Proliferative diabetic retinopathy was more common with patients having poor glycemic control and in IDDM patients. FA was very helpful in detecting microaneurysms and for exact localization of neovascularization, and other microangiopathic lesions as well as for permanent record.

Adult↗
PubMedDate not supplied

A study of high fat and cholesterol induced lipoprotein changes in first degree relatives of patients of myocardial infarction.

The effect of seven days feeding of high cholesterol and high fat breakfast (HCFB) (79.5 g fat, 1655 mg cholesterol) and its withdrawal was studied on 20 first degree relatives of patients of myocardial infarction (Group A) and 18 controls (Group B). All subjects were young (30 years of age) and had no other risk factor for ischaemic heart disease (IHD). At basal level the first degree relatives had significantly lower values for all lipid fractions except that of HDL. In the control group seven days after giving HCFB a significant rise occurred in all lipid fractions except LDL. The rise of HDL was dominant which led to a significant reduction in LDL/HDL ratio. However, in the first degree relatives no significant change could be observed in any lipid fraction. Seven days after the withdrawal of HCFB there was a significant reduction in all lipid fractions in controls but in first degree relatives the cholesterol level increased significantly from its basal value. However, other lipid fractions showed no significant change, and LDL/HDL ratio remained constant throughout. These different types of behavioural responses to cholesterol could be helpful in identifying high risk hereditarily predisposed persons at early age when basal lipid values are inconclusive.

Adult↗
PubMedDate not supplied

Effect of administration and withdrawal of oral contraceptive pills on serum lipids and lipoproteins.

We studied the effects of oral contraceptive pills (OCP) supplied by the Govt of India in its Family Welfare Campaign, on serum lipid levels of women. The OCP, containing 30 micrograms ethinyl estradiol and 1 mg of norethisterone acetate were administered to the women for six months continuously and serum lipid levels were estimated after three and six months of the treatment. There were no significant changes in serum cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), serum triglycerides and very low density lipoprotein (VLDL). In a simultaneous study we also measured serum lipid levels at 3 and 6 months after withdrawal of the pills in women who had been receiving OCP containing 50 micrograms of ethinyl estradiol and 0.5 mg of one of the progesterones for the past 1 1/2 to 2 years continuously. Only serum LDL level fell significantly (P less than 0.01) on 3 months withdrawal period. It is concluded that 6 months of usage of the OCP marketed by the Govt. of India does not affect the serum lipid profile.

Adult↗
PubMedDate not supplied

Causes of limb loss in civilian arterial injuries.

Progress in the management of complex vascular injuries of the extremities has not eliminated the necessity for amputation. An analysis of 100 consecutive patients treated at the Lincoln Medical and Mental Health Center during 1974-1980 disclosed that five amputations followed 24 instances of blunt trauma, but only one minor amputation of toes was required in 76 patients after repair of arterial injuries associated with penetrating wounds. Extensive skeletal, muscular and skin loss at the sites of blunt trauma precluded salvage of two limbs. Physicians' failure to suspect arterial injury on admission in three patients with blunt trauma caused delay in the diagnosis and management of occlusive arterial injury that ultimately led to three amputations. In contrast, limited soft tissue damage accompanying penetrating wounds and high index of suspicion resulted in expeditious repair, accounting for the minimal risk of limb loss. Amputation may be obligatory in the presence of extensive skeletal and soft tissue destruction. However, limb loss due to delay in diagnosis is preventable. In every instance of blunt trauma to extremities, we advocate the same suspicion of vascular injuries as in penetrating trauma, with early liberal use of angiography whenever pulses are not absolutely normal, and prompt revascularization of ischemic limbs.

Adult↗
PubMedDate not supplied

Systemic organ assessment using computerized profiles.

Clinical monitoring of isolated parameters may lead to erroneous conclusions or conflicting speculations about the patient's general physiological status. Data derived from two or three primary parameters may provide a better understanding of the patient's overall status. Four automated profiles have been designed to aid in the management of critically ill patients. Data obtained from simple blood and urinary tests are used to compute parameters for various physiologic, renal, respiratory, and metabolic functions. The derived data are plotted in hard-copy form. A sequential series of each profile assists the physician in making intelligent and rapid therapeutic decisions and in evaluating the effectiveness of this therapy.

Computers↗
PubMedDate not supplied

Microfilariae in association with neoplasms. Report of six cases.

Microfilariae were observed during routine cytopathologic or histopathologic examination of tumor tissue from six neoplasms. Subsequent to the detection of the parasite in smears or sections, repeated examination of night blood smears from these patients demonstrated microfilariae in only one case of squamous-cell carcinoma of the cervix. Histopathologic examination of the serial sections revealed different types of unrelated tumors, but no microfilariae could be demonstrated except in one case of hemangioblastoma of the cerebellum.

Adult↗
PubMedDate not supplied

Autologous fibrin adhesive in experimental tubal anastomosis.

OBJECTIVE: To evaluate autologous fibrin in rabbit oviduct anastomosis versus 7-0 vikryl, a conventional suture material used in tubal anastomosis. METHODS: Thrombin was added to the autologous fibrinogen at the site of anastomosis to obtain a tissue adhesive. The anastomotic time, pregnancy rate, and litter size were evaluated. Three months later, a relaparotomy was done to evaluate patency and degree of adhesions, and a tubal biopsy was taken from the site of anastomosis. RESULTS: Analysis of results showed a statistically significant (P < .001) shortened anastomotic time and superior histopathological union in the tissue adhesive group. Patency rate, pregnancy rate, and degree of adhesions were comparable in both groups.

Anastomosis, Surgical↗