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N Adachi

Publications and source records attributed to N Adachi.

At least 217 records · Page 12Linked to original sources
PubMed1986

[Studies on the transfer of cefotaxime into bone marrow blood].

Cefotaxime (CTX) was administered in a dose of 2 g to 20 adult patients prior to orthopaedic surgery. Samples of the bone marrow blood and the forearm venous blood were collected at 30, 60, 90 and 120 minutes after the CTX administration, and the concentration of the drug in each sample was determined. The results are described below. The mean concentration of CTX transferred into the bone marrow blood was 59.7, 28.9, 14.7 and 7.2 micrograms/ml at 30, 60, 90 and 120 minutes after the CTX administration, respectively. The mean concentration of CTX in the venous blood was 84.0, 39.1, 19.0 and 13.8 micrograms/ml at 30, 60, 90 and 120 minutes after the CTX administration, respectively. The mean ratio of the CTX concentration in the bone marrow blood to that in the venous blood was 73.9%, 71.0%, 75.1% and 51.6% at 30, 60, 90, 120 minutes after the CTX administration. From the above results, CTX is considered to be a useful antibiotic if it is administered prior to orthopaedic surgery to prevent infections.

Adolescent↗
PubMed1986

An effective hospital-based pneumococcal immunization program.

We studied a hospital-based pneumococcal immunization program. Ninety (66%) of 136 patients on the study unit (group 1) and 97 (80%) of 122 patients on the control unit (group 2) were candidates for pneumococcal vaccine based on age of 65 years or older or underlying medical condition, or both, and absence of prior vaccination. In group 1, an infection control nurse identified candidates at the time of discharge and offered vaccine. No intervention was made in group 2. Seventy (78%) of vaccine candidates in group 1 were vaccinated at the time of hospital discharge compared with none of 97 candidates in group 2 (P less than .001). A hospital-based program offering vaccine at the time of hospital discharge can significantly improve immunization rates and successfully immunize the majority of hospitalized individuals at high risk from pneumococcal infection.

Adolescent↗
PubMed1983

Pneumococcal vaccine in the hospital. Improved use and implications for high-risk patients.

A randomized trial of a program to improve pneumococcal immunization was undertaken. Also studied were the prevalence of high-risk conditions for serious pneumococcal disease among hospital admissions and prior hospitalization of patients with pneumococcal bacteremia. During two successive winters, 56% of 1,062 medical patients were identified by admission diagnosis or age as having a high-risk condition. None had received prior vaccination. During the trial period, identifying candidates for vaccination increased immunization from two (2.1%) of 95 to ten (10.4%) of 96 in year 1 and from two (2.1%) of 96 to 19 (20%) of 95 in year 2. Among adults with pneumococcal bacteremia, 33 (54%) of 61, including 32 (64%) of 50 with high-risk conditions, had documentation of prior hospitalization within five years. A hospital-based program can increase pneumococcal immunization rates and would be directed at patients in whom serious pneumococcal disease is likely to develop.

Adolescent↗
PubMed1983

Prealbumin and immunoglobulin in serum and cerebrospinal fluid in familial amyloid polyneuropathy.

Prealbumin, immunoglobulin G, A, and M concentrations in serum and cerebrospinal fluid from patients with familial amyloid polyneuropathy (Japanese type) were determined and compared with those of asymptomatic relatives or controls. Prealbumin concentrations were not significantly different between them. Using polyacrylamide disc-gel electrophoresis, no qualitative difference in the serum prealbumin was found between them. Among the serum immunoglobulins, only the immunoglobulin A concentration was significantly elevated in the patients as compared with asymptomatic relatives.

Amyloidosis↗
PubMed1983

[Evaluation of prognostic factors in hepatocellular carcinoma using multiple regression analysis].

We analysed the relationship between 19 prognostic factors and the life span of patients with hepatocellular carcinoma. Among 52 patients who had been admitted to the Gifu Prefectural Gifu Hospital, in 46 the pathological diagnosis was confirmed. We selected 9 of 19 variables by the stepwise forward regression method. These were Arels Classification, ascites, HBsAg, performance status, method of therapy, sex, GOT, albumin and bilirubin. Results of multiple regression analysis demonstrated that the presence of ascites is the most important factor; other significant factors are Ariel's Classification, performance status, positivity of HBsAg, method of therapy, and GOT. These parameters were paralleled with the survival curves, most of which had been categorized. Although intra-arterial infusion of ADM was considered the most favourable treatment method, the survival curves suggested that other methods were equally effective.

Adult↗
PubMed1982

[Chemotherapy of hepatocellular carcinoma--with special reference to one-shot intra-arterial infusion of a high dose of adriamycin].

Twenty-two cases of non-operable hepatocellular carcinoma (HCC) were treated with three types of chemotherapy mainly with Adriamycin (ADM). In the group (A), one shot intraarterial infusion of 100 mg ADM into the hepatic artery (9 cases), group (B), one shot intraarterial infusion of 30 mg ADM (3 cases), and group (C), 20-60 mg of systemic administration of ADM (10 cases) were examined. The therapeutic effects and side effects were studied comparatively among these three groups. In terms of tumor regression, RR was 4 cases (44.4%), and MR was 4 (44.4%) in group (A), and PR was 1 (10%) in group (C). The average survival time was 8.3 months (5 cases are still alive) in group (A), 5.7 months in group (B), and 4.2 months in group (C), respectively As side effects, alopecia was found 100% in (A), 33% in (B); leukocytopenia was found 100% in (A), 33% in (B); but no serious complication due to leukocytopenia was observed in any of them. One shot of 100 mg of ADM intraarterial infusion therapy seemed to be superior in therapeutic effects against HCC over other therapies.

Aged↗