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Biomedical subjects

N A Solov'eva

Publications and source records attributed to N A Solov'eva.

At least 19 recordsLinked to original sources
PubMed2006

Glutamate release in the nucleus accumbens during competitive presentation of aversive and appetitive stimuli.

In vivo intracerebral microdialysis/HPLC studies on Sprague-Dawley rats showed that simultaneous presentation of food and a tone previously combined with a pain stimulus was accompanied by transient elevation of the glutamate level in the extracellular space of the nucleus accumbens, the extent of this increase being proportional to the latent period of initiation of the act of eating. Conversely, sequential presentation of the conditioned aversive signal followed by food and isolated presentation of the conditioned aversive signal alone were not accompanied by changes in the level of extracellular glutamate. It is suggested that glutamate release in the nucleus accumbens in conditions of competition between presentation of food and a tone previously combined with pain stimulation is not related to the process of selecting between the aversive and appetitive strategies of behavior, but may be associated with inhibition of preparation to perform or performance of the food-related behavior.

Animals↗
PubMed2006

[NO-synthase dependent increase in citrulline extracellular level in the nucleus accumbens during acquisition and expression of conditioned emotional response].

In Sprague-Dawley rats, by means of in vivo microdialysis combined with HPLC analysis, it was shown that acquisition and expression of conditioned emotional response resulted in increase in extracellular level of citrulline: a nitric oxide co-product, in the nucleus accumbens. The rise extracellular citrulline caused by the acquisition of the response was significantly reduced by intraaccumbens infusion of 7-nitroindasole (0.5 mM), a selective inhibitor of neuronal NO-synthase, and completely prevented by intraaccumbens infusion of N-nitroarginine (0.5 mM): a nonselective NO-synthase inhibitor. The increase in citrulline extracellular level cased by expression of the conditioned emotional response is completely prevented by infusion of both NO-synthase inhibitors. The data obtained suggest that the acquisition and the expression of the conditioned emotional response increase the production of nitric oxide in the n. accumbens, predominantly due to activation of the neuronal NO-synthase.

Animals↗
PubMed2005

Tetrodotoxin-dependent glycine release in the rat nucleus accumbens during correction of feeding behavior.

Studies on male Sprague-Dawley rats using vital intracerebral microdialysis and high-performance liquid chromatography addressed changes in glycine levels in the intercellular space of the nucleus accumbens during forced correction of feeding behavior. The results showed that presentation to food-consuming rats of a tone previously combined with pain stimulation induced increases in extracellular glycine levels in the nucleus accumbens, which was completely prevented by administration of the sodium channel blocker tetrodotoxin (1 microm) into this structure. Isolated presentation of the tone previously combined with pain stimulation and combined presentation of food and a tone not associated with pain stimulation were not accompanied by glycine release. These data provide evidence for the involvement of glycine mechanisms of the nucleus accumbens in processes associated with forced correction of feeding behavior.

Animals↗
PubMed2004

[Tetrodotoxine-dependent glycine release in the rat nucleus accumbens during correction of feeding behaviour].

Presence of a tone previously paired with a foot-shock in rats during food intake increases the glycine extracellular level in the n. accumbens. The increase will be completely prevented by intra-accumbal infusion of Na-channel blocking agent tetrodotoxine. The findings suggest that glycine mechanisms in the n. accumbens are involved in the correction of feeding behaviour.

Animals↗
PubMed2002

[Eradication of Helicobacter pylori in patients with duodenal ulcer following the short course of treatment with azitromycin and amoxycillin].

The efficacy of short-term treatment with azithromycin in 17 patients with acute doudenal ulcer associated with H. pylori was evaluated. Bioptats of the gastric mucosa taken at the beginning and after one month of treatment were investigated for H. pylori presence by histological, bacteriological methods, by urease test and by PCR. All the patients with positive H. pylori test were treated with Gastrozol (omeperazole, ICN Pharmaceutical) 40 mg per day for 1 week followed by 20 mg per day for 3 weeks, Sumamed (azithromycin, peira) 0.5 g once daily for 3 days and amoxycillin 0.5 mg four times a day for 10 days. Bioptats analysis before treatment revealed H. pylori in 100% for PCR methods, in 94.1% for urease test, in 88.2% for histological test. After the treatment H. pylori was revealed in 12.5% for urease and histological test, in 18.8% for bacteriological test and in 25% for PCR test. Thus the treatment efficacy was 75%. Side effects for short-term azithromycin therapy were shown in 5.9% cases.

Adult↗
PubMed2002

[Diagnosis and surgical treatment of primary hyperaldosteronism].

Primary hyperaldosteroneism (PHA) is one of the main causes of secondary arterial hypertension (AH). Medical histories of 62 patients with PHA were analyzed. aldosterone-produced adenoma (APA) was diagnosed in 37 (59.7%) patients (all of them were operated), idiopathic hyperaldosteroneism (IHA)--in 25 (40.3%) patients, 11 of them were operated. Complex clinical and instrumental examination (hormonal analysis, USI, CT, MRT, in difficult cases in 35 patients--selective phlebography with blood sampling) was carried out in all the patients. Clinical picture in the majority patients with PHA was unclear. Hypokaliemia is not obligatory symptom of PHA. AH is often the only symptom of PHA, therefore all the patients with AH require complex laboratory examination including repeated detection of potassium blood level, examination of serum aldosterone concentration and renin activity, diurnal urinary excretion of aldosterone. In difficult differential diagnosis between APA and IHA it is necessary to perform selective phlebography with blood sampling from inferior cava and adrenal veins with obligatory detection of aldosterone and hydrocortisone concentration. Diagnostic and curative algorithm are developed. Surgical treatment is indicated for patients with APA, and also for ones with IHA who had functionally dominant adrenal gland (based on selective blood sampling analysis) and resistant for drug therapy AH.

Adrenal Glands↗
PubMed2001

[Methods of Helicobacter pylori detection].

There is the HP diagnostic methods review. The classification of main methods is presented. Diagnostic significance and defects of all these methods were demonstrated. There are own data of HP and its strains revealing in the patients with duodenal peptic ulcer.

Duodenal Ulcer↗
PubMed1997

[Clinical and morphological analysis of adrenal cortex adenomas].

Case 31 patients with Cushing syndrome are analysed. On the basis of the number of the atypical cells from dark-cell adrenal cortex adenomas, giant-cell adenomas were differentiated as a separate morphological type. Blood concentration of hydrocortisone depends on the cell composition of adenomas. Clear-cell adenomas can be hormone-active and hormont-inactive. The quantitative parameters oblained NMR-tomography, allow detecting morphological type of the tumor with greaf accuracy.

Adolescent↗
PubMed1996

[Sipple syndrome].

Explore the source record for details and available documents.

Adrenal Gland Neoplasms↗
PubMed1995

[Oxidative phosphorylation activity, F0F1-ATPase and level of liver mitochondrial cytochromes in rats with congenitally increased ability for free radical formation].

The rates of oxygen consumption in liver mitochondria of strain S rats (2-3- and 10-12-months-old) with inherited free radical hyperproduction during oxidation of three types of substrates (glutamate+maleate, succinate+rotenone and ascorbate+TMPD) as well as cytochrome a level in the respiratory chain are lowered in comparison with Wistar controls. In liver mitochondria of 10-12-months-old rats these changes are more pronounced and manifest themselves as decreased ADP/O, phosphorylation rates and F0F1-ATPase activity. The phosphorylation potential, ATP content and adenine nucleotide pool in rat liver are also reduced. The experimental results give a better insight into the pathogenetic mechanisms of morbid states (e.g., degenerative diseases) in human beings and shed additional light on the origin of short lifespan and premature in strain S rats.

Animals↗
PubMed1995

[Several functional and diagnostic criteria in the evaluation of the state of the neuromuscular function of arms of workers exposed to the effects of local vibration].

The authors studied neuromuscular apparatus of hands in workers subjected to local vibration and in patients having vibration disease (VB). If compared to apparently healthy individuals both exposed to vibration or not, the VB patients proved lower muscular durability (MD) of hands, higher oxyproline excretion (OB) and greater MD/OB ratio. The studied parameters (MD, OB, MD/OB) in the VB patients turned out to be similar in the VB patients and the healthy examinees having initially low MD (under 29 s). The suggested criteria were recommended for early diagnosis of neuromuscular disturbances in hands and for occupational selection.

Adult↗