Search PubMed⌕ Search

Biomedical subjects

N A Probatova

Publications and source records attributed to N A Probatova.

79 records · Page 5Linked to original sources
PubMedDate not supplied

[Argyrophilic proteins in the regions of nucleolar organizers are markers of cell proliferation rate].

The paper reviews the literature on the role of the above proteins in the mechanisms of cell cycle regulation and presents data on changes in protein expression in dynamics of cell cycle. The significance of studies dealing with the expression of these proteins, which, along with the assessment of a cell population growth fraction, allow one to characterize the rate of cell proliferation that under malignant growth is the determinant of cell proliferative status, which has a great impact on tumor progression, is discussed. The data on the diagnostic value of these proteins as an independent predictor for a broad spectrum of tumors are considered.

Antigens, Nuclear↗
PubMedDate not supplied

[Diagnosis of visceral leishmaniasis].

The differential diagnosis between visceral leishmaniasis and lymphoplasmacell polimorphocell lymphosarcoma may be difficult. One case is described in which electron microscopy allowed detection of Leishmania in the histiocytes of the spleen.

Adult↗
PubMedDate not supplied

[Immunoblastic lymphadenitis: pathohistologic picture and differential diagnosis from malignant lymphoma].

Immunoblastic lymphadenitis is a T-cell immune hyper-response to antigenic stimulation. Patho-histologically, polymorphic hyperplasia of the lymph node pulp with a widening of the paracortical zone and the disturbance of the node structure is found. The cells of the paracortical proliferate are represented by small lymphocytes, stimulated lymphoid cells of varying size with numerous immunoblasts, plasma cells at various stages of maturation including lymphoplasmocytoid ones. When the structure of the lymph node is disturbed immunohistochemical examination is necessary to reject malignant lymphoma.

Adult↗
PubMedDate not supplied

[Nucleolar organizer as a marker of malignancy grade and prognosis of non-Hodgkin's malignant lymphoma].

There were 51 cases of non-Hodgkin's malignant lymphoma (NHL) and 9 cases of reactive follicular hyperplasia among 60 cases of lymphoproliferative conditions. According to the Kiel classification, lymphomas of a low grade of malignancy (17 cases) and lymphomas of a high grade of malignancy (34 cases) were distinguished among NML. Significantly higher activity of the nucleolar organizers (NO) was observed in lymphomas of a high malignancy grade, particularly in lymphomas formed of cells of early differentiation stages, and enhancement of NO activity with development of lymphoma aggression. "Anomalies" of NO activity expression reflecting clinical lymphoma presentation were noted among NML of various malignancy grade. NML with a high NO activity are described as having less favourable prognosis compared to lymphomas with low NO activity. No significant difference in NO activity was found between reactive follicular hyperplasia and follicular centroblast-centrocytic lymphoma. Thus, NO activity can be considered as an additional diagnostic marker of NML grade of malignancy and prognosis.

Biomarkers, Tumor↗
PubMedDate not supplied

[Aminopeptidases in cells of non-Hodgkin's lymphoma of varying degrees of malignancy and in lymphogranulomatosis].

26 cases of lymphoproliferative diseases were studied: 8 cases of reactive follicular hyperplasia (RFH), 11 cases of non-Hodgkin's malignant lymphomas (NML), 7 cases of lymphogranulomatosis (LGM). Only gamma-glutamyl transpeptidase (GGT) was found in lymphoid cells of B- and T-dependent areas of lymph nodes with reactive changes as well as in tumor cells of NML and LGM. GGT activity was more pronounced in NML of high-grade malignancy (centroblast and immunoblast) as compared to lymphomas of lower grade of malignancy (lymphocytic, centroblast-centrocytic and in Lennert lymphoma). GGT activity in cells of Hodgkin and Berezovsky-Sterberg in some cases of LGM was high, in others low. Significant differences in GGT activity between RFH and follicular centroblast-centrocytic lymphoma were not found. Activity of aminopeptidase M was observed in histiocytes, fibroblasts, vessels and areas of connective tissue growth. Aminopeptidase A activity was observed in vessels only. Activity of dipeptidyl(amino)peptidase IV was observed in some lymphoid cells in RFH, NML and LGM. Thus, GGT activity may be considered as a differential-diagnostic marker in separating NML of high and low degree of malignancy and this may presume a different sensitivity to the therapy.

Aminopeptidases↗
PubMedDate not supplied

[Main principles and diagnostic criteria for revision of the european-american classification of lymphoid neoplasms (T-cell lymphomas and Hodgkin's disease].

Diagnostic criteria of T-cell lymphoma and Hodgkin's disease are presented which are the basis of the European-American classification schema (REAL). Brief morphological, immunophenotypical, genetic and clinic characteristics of every tumor type (subtypes variants) are given. The comparison of this REAL section with the Kiel's classification is made with some critical notes concerning, in particular, the Hodgkin's disease classification.

Hodgkin Disease↗