Peripheral blood and bone marrow morphology, blood and bone marrow lymphocyte subpopulation composition were studied in two children with cyclic neutropenia, using flow cytofluorometry, monoclonal antibodies, colony-forming capacity of granulocytic macrophagal precursors in semi-fluid agar. The studies were conducted in varying periods of the neutropenic cycle. Differences were revealed in immunohematologic parameters and clinical course of neutropenia in the two patients. The analysis of the literature data and the authors' own observations of the patients with cyclic neutropenia permitted a suggestion on high heterogeneity of pathogenetic mechanisms of this disease.

Adolescent↗

PubMedDate not supplied

[Otorhinolaryngologic aspects of histiocytosis X in children].

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Adolescent↗

PubMedDate not supplied

[Experience in using hydrotherapy in children with acute lymphoblastic leukemia at a sanatorium].

34 children aged 10-15 years in long-term remission of acute lymphoblastic leukemia were on combined rehabilitation for concomitant diseases. Adjuvant balneotherapy promoted improvement in the heart rate and decreased asymmetry of circulation. No side effects were registered.

Adolescent↗

PubMedDate not supplied

[Morbidity from leukemia and non-Hodgkin's lymphoma in the juvenile population of various territories of Briansk district].

Annual incidence of acute leukemia (AL) and non-Hodgkin lymphoma (NHL) per 100,000 residents aged 0-15 years has been compared for 6 South-West regions (supervision territory), 21 control regions (comparison territory) and Bryansk city. Childhood population of the supervision territory, radionuclide contaminated after the Chernobyl accident, was 58,600 residents, that of comparison territory and Bryansk city 158,600 and 98,900, respectively (1992). In 1986-1991 59 ALL cases (annual incidence 3.11 per 100,000), 7 ANLL cases (0.38) 2, 1 and 19 of unspecified leukemia, CML, NHL (1.00), respectively, have been registered. Incidence rate and age distribution for both AL and NHL were typical for childhood population of industrial countries. AL incidence was highest in Bryansk city (4.21), in supervision territory it was 4.1, in comparison regions 3.05. There was a statistically significant excess of AL incidence in 1986 among those aged 0-15 years in the supervision territory based on 8 cases (annual incidence 13, 7, a 95% confidence interval 6-27).

Adolescent↗

PubMedDate not supplied

[Retrospective evaluation of blood immunologic parameters in the course of remission of acute lymphoblastic leukemia in children].

The authors investigated cellular and humoral immunity in 53 children over 3 years of age suffering from acute lymphoblastic leukemia. The children had remission lasting from 6 to 120 months and were followed up for 7-14 years after the diagnosis was made. The treatment was performed according to programs of polychemotherapy practiced in 1981-1988. In November of 1995 42 children were alive, 15 had the disease for 10 years. Lymphocytopenia (absolute number of T-cells and B-cells fell 3-5 and 2-3-fold, respectively) was reported in all the examinees both in early remission and later (6-12, 24-60, 60 and more months since the disease onset). In early remission there was a significant reduction in the serum IgG, IgA and IgM. In children with ALL lethal outcome serum IgM and absolute number of E-RFCa dropped in early remission more significantly indicating deep drug-induced depression of lymphocytopoiesis. After 5 years of treatment the pool of peripheral T-lymphocytes and T/B lymphocyte proportion changed for the best, though their absolute number was subnormal. Serum IgG, IgA and circulating immune complexes were 1.3-1.5 times higher than normal which may be explained by gastrointestinal pathology and food allergy in the majority of children treated.

Child↗

PubMedDate not supplied

[Subpopulations of peripheral blood neutrophils and lymphocytes in children with immune neutropenia].

Peripheral blood (PB) neutrophils and lymphocytes from 14 patients with immune neutropenia were studied using the technique of rosette-formation in 2 neutrophil fractions with diverse specific density. All the neutropenia cases were divided into 2 groups by phagocytosis completeness in all the PB neutrophil types studied. Patients of group 1 had impaired phagocytosis D-RFN in elevated levels of these cells, autorosette-forming lymphocytes and neutrophils. Patients of group 2 had defective phagocytosis D-RFN and EAC-RFN in combination with extremely high contents of autorosette-forming including early lymphocytes. The above complex of techniques may be used for prediction of the duration and severity of neutropenia which is important for further selective studies into the causes of neutropenia and effective treatment.

Case-Control Studies↗