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Biomedical subjects

N A Fedorova

Publications and source records attributed to N A Fedorova.

At least 19 recordsLinked to original sources
PubMed1992

[Effect of HMG proteins and their phosphorylated forms on the process of transcription in neuronal nuclei of the rat brain (data from an immunochemical analysis)].

It was found that chromatin transcription in the neuronal nucleus of rat brain is inhibited by antisera to proteins HMG 14, HMG 17 and HMG 2. It is known that chromatin transcription of the neuronal nucleus and phosphorylation of chromosomal proteins are activated by etimizol. The phosphorylation of chromosomal proteins activated by etimizol is inhibited by the antiserum to HMG 14 (but not to HMG 17). The data obtained are suggestive of a possible role of HMG proteins and their phosphorylated forms in the regulation of transcription.

Animals↗
PubMed1991

[High mobility group proteins: structure, localization, function].

High motility group proteins (HMG) are extracted by 5% HCIO4 and 0.35 M NaCl and are characterized by low molecular mass and a high content of acidic and basic amino acids. There is evidence that HMG are involved in the formation of transcriptionally active chromatin.

Amino Acids↗
PubMed1991

[The clinical instrumental evaluation of treatment efficacy in patients with concomitant atherosclerosis of the coronary, cerebral and peripheral arteries].

The loading tests, instrumental and biochemical methods were employed to study the effect of mildronate, dalargin, rokornal, gevilon, dibunol, emoxipine and plasmapheresis on the coronary, cerebral, peripheral circulation, the level of cholesterol, its fractions and triglycerides in 247 patients suffering from atherosclerosis. Mildronate, dalargin, rokornal, emoxipine and plasmapheresis were shown to exert a beneficial effect on the regional circulation, lipid metabolism and can be used in the treatment of patients with concomitant forms of atherosclerosis.

Adult↗
PubMed1975

Renaturation of DNA from ultrasonically fragmented chromatin.

The rates of renaturation of ultrasonically treated DNA, isolated from fragments of rat liver chromatin, were compared. Chromatographic fractionation on hydroxylapatite was used to fractionate the denatured and renatured DNAs. It was shown that DNA fraction 1 renatures considerably faster than fraction 2. The results are compared with previously published data on the specificity coefficient of DNA, the content of basic amino acids and alkali-labile phosphorus of the protein in the corresponding fragments of the chromatin. The possible functional role of these fragments in the genome is discussed.

Animals↗