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N A Elizarova

Publications and source records attributed to N A Elizarova.

At least 19 recordsLinked to original sources
PubMed2003

[Short-chain fatty acids and implications of their measurement in the diagnosis of encephalopathies].

Sixty patients with chronic hepatitis of various etiology at the stage of hepatic cirrhosis with hepatic encephalopathy syndrome (HES), thirty patients with cerebral atherosclerosis with dyscirculatory encephalopathy (DE) and 60 healthy controls have been examined in the study of basic diagnostic criteria of encephalopathies by short-chain fatty acids (SCFA) serum levels. Sensitivity and specificity of this test was also evaluated. Gas-liquid chromatography determined SCFA in the feces and peripheral blood serum from the above examinees. It was found that relative consent of SCFA and for the most part profiles of propionic and fat acids, acids with long chains, SCFA isomers in patients with encephalopathy of different genesis correlate with the results of clinical, laboratory and psychometric methods of examination and should be used together. Basic criteria are devised.

Brain Diseases↗
PubMed1988

[Severe and malignant arterial hypertension: the optimal treatment].

54 patients were treated with a combination of capoten and diuretics for 40 to 250 days. Some patients had been subjected to the "nitroprusside test" prior to medication. The relation between the clinical state, the perilimbal and eye fundus microcirculation and degree of BP decrease were studied using fluorescent angiography. An adequate (for this group of patients) effect was observed when blood pressure decreased by 25-30% as compared to the initial level. For this capoten, up to 150 mg per day, is sufficient. However, when the BP during the "nitroprusside test" and capoten "overdosage" fell by 35-40% or more as compared to the basal level, undesirable changes were observed. The angioarchitecture deteriorated considerably due to a significant increase in the number of non-perfused vessels and vast ischemic zones as compared to the initial state.

Adolescent↗
PubMed1987

[Use of peripheral vasodilators with different mechanisms of action in treating heart failure patients].

The efficacy of peripheral vasodilators with various mechanisms of action was studied in 26 patents with congestive heart failure, left ventricular dilatation and valvular regurgitation. An acute pharmacological test using prazosin was used in all the patients, 20 of them were given a 15-day course of prazosin therapy, 19 patients received a prolonged course of prazosin therapy (over 3 mos.), 15 patients were given a 15-day course with a combination of isosorbide dinitrate and hydralazine. ECG monitoring, catheterization of the right cardiac chambers, thermodilution, and tetrapolar impedance plethysmography were employed. Heart rate, arterial pressure, parameters of cardiac pre- and afterload and pulmonary hemodynamics were studied. Prazosin and isosorbide dinitrate in combination with hydralazine showed a high clinical efficacy in the treatment of patients with congestive heart failure. The improvement of clinical symptomatology was accompanied by considerable positive shifts of the central and peripheral hemodynamics. No considerable differences in the efficacy of prazosin and the combination of isosorbide dinitrate with hydralazine were revealed.

Adolescent↗
PubMed1987

[Clinical significance of diastolic-systolic coefficients of the tetrapolar chest rheogram in patients with ischemic heart disease].

The authors worked out the method and formula of indirect determination of the left ventricular and diastolic pressure (LVEDP) on the basis of the determined direct relationship between the diastolic-systolic coefficient (DSC) of the differential chest rheogram (difTPCR) and the LVEDP value measured by direct method in patients with IHD. LVEDP = 18.4x + 5.5, where x = DSC TPCR. It was determined that difTPCR can help to determine the degree of the heart failure and to find out patients with unfavourable prognosis.

Adult↗
PubMed1986

[Use of prostenon in the treatment of severe and malignant forms of hypertension].

Forty-five patients with high arterial hypertension (AH) refractory to hypotensive therapy were treated with 3 or 4 prostaglandin E2 (PGE2) infusions (Prostenon). Twenty-two of those had the malignant AH syndrome. The hypotensive effect of prostenon was most pronounced in patients with essential hypertension, less marked in those with chronic glomerulonephritis and pyelonephritis and virtually nonexistent in cases of renovascular hypertension. It persisted until the discharge in most patients, and for several months in some. In severe AH, prostenon improved blood supply to the brain, kidneys and, less notably, the limbs, normalized venous dilatability and the cardiac index, brought down total peripheral resistance, particularly in cases where pretreatment values had been high, reduced platelet aggregation 1.8-fold, and contributed to reverse development of eyeground changes in some patients with malignant AH syndrome.

Adult↗
PubMed1986

[Comparative evaluation of prostaglandins E1 and E2 in patients with hypertension].

Changes in ABP, ECG, cerebral and peripheral hemodynamics were examined in 29 patients with second-stage essential hypertension before and within 1 or 2 days after PGE1 and PGE2 infusions administered during follow-up or in the presence of a hypotensive therapy. PGE were shown to be active vasodilators increasing cerebral and peripheral circulation. Vascular PG effects persisted for 1 or 2 days after the administration. Hypertensive patients demonstrated two patterns of hemodynamic response to PGE. The patients with higher total peripheral resistance (TPR) and low stroke and cardiac indices (SI and CI) during follow-up or hypotensive treatment were more sensitive to PGE, their ABP falling because of declining TPR. The patients with high SI and normal or slightly elevated TPR were less sensitive to PGE, their ABP falling mostly at the expense of declining SI. Most patients showed changed end portion of the ventricular complex immediately after PGE administration that vanished within one or two days. In coronary patients, angina of effort occurred less frequently after PGE infusion.

Adult↗
PubMed1982

[Regional circulatory changes in heart failure as affected by intravenous nitroglycerin administration].

The effect of nitroglycerin intravenously injected in 23 patients with heart failure (stage A and stage B), on the regional blood circulation (the chest, abdominal cavity, crus and finger) was studied by the method of impedansplethysmography. Various reactivity of capacious and resistive vessels of different vascular regions was found in reply to an intravenous injection of the drug. The redistribution of the venoarterial circulation in the regions studied occurred depending on the changes in the central hemodynamics. While administering nitrates to patients with circulatory failure it is necessary to take into account the state of the central and regional hemodynamics in the initially high total peripheral resistance. The control over changes of the pulse blood filling in different vascular vessels under the influence of nitroglycerin may be sufficiently informative for the choice of individual doses of the vasodilator and the assessment of the effectiveness of the therapy.

Abdomen↗
PubMed1981

[Various methods of determining left ventricular stroke volume by using echocardiography].

The determinations of stroke volume (SV) were used with the aid of different formulae in patients with the ischaemic heart disease with areas of akinesia of the left ventricle, and those with the acquired mitral and aortal valve disease, congestive cardiopathy and in healthy individuals. Tetrapolar rheography was used as control. The calculation of SV with echocardiogram of the left ventricle in patients with areas of akinesia of the left ventricle and valvular regurgitation gives unduly high figures. The same data have been obtained in determining the SV with echocardiogram of the mitral valve with relative insufficiency. The figures of SV calculated with the echocardiogram of the aortal valve in patients with the disease of the aortal valve are lower as compared to the rheographic data.

Adult↗
PubMed1978

[Comprehensive study of central and regional hemodynamics in hypertension using bloodless research methods].

Tetrapolar chest rheography is a convenient, noninvasive method for determining the stroke and minute blood volumes. Its application made it possible to reveal various types of hemodynamics in patients with hypertensive disease and apply differentiated treatment with due account for these peculiarities. Study of regional hemodynamics showed a significant increase in the tonus of the arteries of the brain and crura and diminished tonus of the veins. The method is most valuable in a follow-up during treatment and particularly for recording rapid shifts in hemodynamics in functional loads. Assessment of the reactions of patients with hypertensive disease during the orthostatic test revealed various degrees of disorders of the circulatory system adaptation mechanisms; with the progression of the disease these disorders become more intense.

Adolescent↗
PubMed1977

[Determination of cardiac output by the method of tetrapolar chest rheography and evaluation of its metrological possibilities].

Tetrapolar chest rheography is an up-to-day, convenient and bloodless method of determining the cardiac stroke volume (CSV) and cardiac output (CO) in dynamic observations. The paper presents and analysis of the method and considers the possibilities and limits of its application in determining the stroke volume and cardiac output. Advantages of the Kubicek procedure as modified by the authors by comparison with other rheographic methods are shown, along with methodological procedures employed for dtermining the CSV and CO and a nomogram that significantly facilitates the calculation of the values under study is offered. Results of contrasting the cardiac ejection values in patients with congenital heart diseases and an increased pulmonary circulation as against those in patients with ischemic heart disease, obtained by means of tetrapolar chest rheography and direct Fick's method are cited. The possibility of applying tetrapolar chest rheography in assessing the effect operative treatment in patients with congenital cardiac defects and also when investigating compensatory reactions of the cardio-vascular system in patients with hypertensive disease in the course of the orthostatic and Valsalva tests is demonstrated.

Adult↗