This report is a follow-up of the original case of granular cell odontogenic cyst described by Gold and Christ in 1970. The lesion, originally treated by enucleation in 1965, recurred 18 years later as a follicular ameloblastoma with prominent plexiform and acanthomatous histologic patterns. No histologic evidence of granular cells was noted in the recurrent lesion. The recurrent ameloblastoma was treated by marginal resection of the body of the mandible and immediate reconstruction with an iliac bone graft. The anatomic restoration was excellent, and there is no recurrence 5 years postoperatively. This case supports the view that the granular cell odontogenic cyst is a unicystic (monocystic) granular cell ameloblastoma, and that the presence of granular cells in ameloblastoma is not a permanent feature and may be of little value as a prognostic indicator of aggressiveness.

Ameloblastoma↗

PubMed1987

Oral Kaposi's sarcoma in acquired immune deficiency syndrome.

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Acquired Immunodeficiency Syndrome↗

PubMed1981

American Burkitt's lymphoma manifested in a solitary submandibular lymph node.

An interesting and unusual case of undifferentiated lymphoma, Burkitt's type, solely presenting as a submandibular mass in a 24-year-old white American man has been presented. Although surface marker studies were not undertaken, the morphologic and cytologic aspects of the lesion fulfilled the requirements for a diagnosis of Burkitt's lymphoma. The patient is under chemotherapy and careful follow-up and seems to be clinically free of residual disease.

Adult↗

PubMed1981

Case 33, part 1.

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Adult↗

PubMed1981

Case 33, part 2. Ameloblastoma of the mandible.

A 34-year-old black man underwent a left hemimandibulectomy with disarticulation for eradication of an extensive ameloblastoma. The resected mandible was immediately reconstructed by means of a titanium crib with an attached artificial condyle, which was overpacked with particulate bone removed from the iliac crest. Postoperative function and esthetics have been satisfactory. Histopathologic examination of the lesion disclosed an ameloblastoma with some features similar to those of a calcifying odontogenic cyst.

Adult↗

PubMed1979

Odontogenic myxoma. Surgical management and an ultrastructural study.

Odontogenic myxoma is a tumor of primitive mesenchyme, probably derived from the dental apparatus. Surgical management of this benign but locally aggressive tumor is either by curettage or en bloc resection. Two cases of odontogenic myxoma of the mandible are reported. In one case, en bloc resection. Two cases of odontogenic myxoma of the mandible are reported. In one case, en block resection with immediate reconstruction was undertaken. In the second case, the neoplasm was thoroughly curetted. The first case was studied by electron microscopy. Six ultrastructural studies of seven odontogenic myxomas have been previously reported. The ultrastructural features of odontogenic epithelium that may be present in myxomas of the jaws have been examined by electron microscopy once before. Our observations are in agreement with those of other workers who suggest that the connective tissue cell is the proliferating component of the tumor and is very similar to a fibroblast but has enough ultrastructural and functional features to deserve the term myxoblast. The majority of the tumor cells are metabolically active and secretory and there is adequate evidence that the tumor matrix consists of large amounts of mucopolysaccharides. It is reasonable, therefore, to conclude that myxoblasts secrete the mucoid matrix that is so characteristic of odontogenic myxomas. Unlike normal or neoplastic fibroblasts, the myxoblasts are not engaged in abundant synthesis of banded collagen throughout the entire lesion.

Adult↗

PubMed1979

Congenital granular-cell epulis. Report of a case.

The congenital granular-cell epulis is an uncommon pedunculated tumor of the alveolar mucosa found only in newborn infants. This lesion can present an alarming appearance and interfere with efforts at nursing. The generally accepted treatment is excision through the pedicle, and recurrence is not to be anticipated. An example of a tumor fulfilling the clinical and histopathologic criteria of this lesion is reported.

Connective Tissue↗

PubMed1978

Clinical bladder cancer in sponge matrix tissue culture: procedures for collection, cultivation, and assessment of viability.

We studied the growth of surgically resected human bladder cancer in three dimensional tissue culture, Observations were made in the living cultures and after the sponge matrix cultures were fixed and prepared as histologic sections. We compared the histologic appearance of each tumor immediately after removal and after a week in culture. In a few instances the donor tumor was kept in medium at room temperature for one day before being inoculated into the matrix. This delay had only slight deleterious effect on the growth in culture. Over 85 consecutive cases have been placed in culture and the first 47 have been evaluated in histologic preparations. Tumors grew into the matrix with distinctly different patterns even when the zero time specimens were of similar histopathology. We also studied several antibiotics to idenify conditions that would suppress the usual urinary bacterial contaminants without producing cytotoxicity to tumor cells by microscopic evaluation. A combination of gentamicin and kanamycin, each at a concentration of 50 microgram/ml was effective.

Culture Media↗

PubMed1974