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Biomedical subjects

Mustafa Bozbuga

Publications and source records attributed to Mustafa Bozbuga.

7 recordsLinked to original sources
PubMed2006

Evaluation of mild head injury in a pediatric population.

Approximately 5 million children present to emergency departments, seeking care for head injuries, each year, and 80% of these children are classified as cases of mild head injury. Due to the huge number of patients and low frequency of intracranial lesions in this group, obtaining a computed tomography scan for each and every patient is a significant economic problem. This study was conducted to identify the clinical parameters and the radiographic findings that may be associated with intracranial lesions in children with mild head injury. 421 patients, with a Glasgow Coma Scale score of 15 and without any focal neurological deficit, were studied. Intracranial lesion was noted in 37 cases (8.8%). Sensitivity of a plain radiogram was 43.2%, and specificity was 93%. An intracranial pathology was demonstrated in 28.9% of the patients with a linear skull fracture. The only clinical parameters associated with an increase in the frequency of detection of intracranial lesions were posttraumatic seizures and loss of consciousness. Age, sex, headache, vomiting and scalp lacerations were not associated with a higher frequency. Even when patients with a history of loss of consciousness or posttraumatic seizure were subtracted from the study group, intracranial lesions were noted in 4.1% of the cases, and in 1.8% neurosurgical intervention was required. Computed tomography is the gold standard in the evaluation of pediatric patients with mild head trauma, and every child who has experienced a head injury should undergo a cranial computed tomography evaluation, even if he or she appears in perfect health.

Adolescent↗
PubMed2006

A case of McCune-Albright syndrome associated with Gs alpha mutation in the bone tissue.

The syndrome of McCune-Albright syndrome (MAS) is clasically defined as a triad presentation with the findings of polyostotic fibrous dysplasia, café-au-lait spots, and sexual precocity. However, not all patients present with complete symptoms. A 52-year-old man was diagnosed as having a variant of McCune-Albright syndrome with the following findings: polyostotic fibrous dysplasia, acromegaly due to pituitary tumor and subclinical hyperthyroidism due to toxic multinodular goiter. Sexual precocity and café-au-lait spots were not noted. Acromegaly was confirmed by laboratory examination (IGF-1, glucose suppression test and TRH stimulation test). Long acting somatostatin analogue was used as treatment. Although the pituitary tumor could not be removed due to technical problems, mass lesions on the cranium were removed subtotally. Histopathological evaluation demonstrated that the lesion complied with fibrous dysplasia. Genomic DNAs were isolated from the craniofacial bones and peripheral leucocytes of the patient. After amplifying the related regions, Gs alpha (Gs alpha) gene was analysed by automatic DNA sequence analysis. An activating mutation of the Gs alpha gene (Arg 201 Cys) was found in the genomic DNA isolated from the bone tissue of the patient, but not in the genomic DNA isolated from the blood. We described a case of MAS associated with Gs alpha mutation in the bone tissue, presenting with polyostotic fibrous dysplasia, subclinical hyperthyroidism and acromegaly.

Acromegaly↗
PubMed2005

Surface anatomy of the posterolateral cranium regarding the localization of the initial burr-hole for a retrosigmoid approach.

Knowing the location of the venous sinuses is essential for the localization of the initial burr-hole for a retrosigmoid approach, in order to avoid inadvertent entry into the venous sinuses and limitation of the size of the bony opening. In this anatomic study, external landmarks of the posterolateral cranium have been studied, in order to reveal the relationship with the venous sinuses. Eighty-four dried adult human skulls were studied and study of both sides yielded 168 sides. Morphometric measurements of the posterolateral cranium have been performed and relations of the external landmarks with the venous sinuses have been studied. The anatomic position of the asterion was variable. The superior nuchal line was roughly parallel and below the lower margin of the sulcus of transverse sinus in all specimens. The sigmoid sinus, between the superior and inferior bends, seemed to descend along an axis defined by the junction of the squamosal-parietomastoid suture and the mastoid tip, in a slightly oblique fashion. In conclusion, a burr-hole placed just below the superior nuchal line and posterior to the axis defined by the mastoid tip and the squamosal-parietomastoid suture junction is appropriate for both avoiding inadvertent entry into the sinus and limiting the size of the craniotomy.

Adult↗
PubMed2005

Hydatid cyst of the craniocervical junction: case report.

OBJECTIVE AND IMPORTANCE: Although rare in developed countries, hydatid disease is a serious parasitic infection in endemic areas. Spinal disease most commonly involves the thoracic region, and involvement of the upper cervical spine is extremely rare. In this report, a case of hydatid disease involving the craniocervical junction is presented, along with a review of the literature. CLINICAL PRESENTATION: A 44-year-old man presented with the complaint of neck pain. The results of his physical and neurological examinations were within normal ranges, except for pain exacerbated by neck motion and spasm of the cervical musculature. Magnetic resonance imaging demonstrated a cystic lesion involving the odontoid process and body of C1 and C2, with thin and regular cyst walls and cyst contents similar in intensity to that of cerebrospinal fluid. The results of serological tests performed with the suspected diagnosis of hydatid disease were positive. INTERVENTION: The patient initially underwent surgery to provide stabilization of the craniocervical junction, using autogenous bone graft and sublaminar wiring from the occiput to C3 via a posterior approach. The cyst was approached via a transoral route, using a U-shaped pharyngeal incision. There were no neurological deficits after surgery. Postoperative magnetic resonance imaging scans confirmed complete excision of the cyst, and the patient was discharged on the 12th postoperative day. He received six cycles of albendazole treatment, each consisting of 28 days with an intervening drug-free period of 2 weeks. Magnetic resonance imaging scans performed 1 year after surgery revealed the patient was still disease-free. CONCLUSION: Hydatid disease should be considered in the differential diagnosis of spinal cord compression, especially in endemic areas. Although the chance of obtaining a cure is unlikely, radical surgery coupled with antihelminthic therapy seems to provide long-lasting relief.

Adult↗
PubMed2004

Morphometric evaluation of subaxial cervical vertebrae for surgical application of transpedicular screw fixation.

STUDY DESIGN: A morphometric evaluation of pedicle projections in 29 cervical spinal columns (C3-C7) for three-dimensional surgical anatomy for safe surgery was proposed. OBJECTIVE: In this study, pedicles and intimate structures of the subaxial vertebrae from C3 to C7 were evaluated to provide some morphometric data for cervical transpedicular screw fixation. SUMMARY OF BACKGROUND DATA: Detailed knowledge of surgical anatomy and variation of the subaxial vertebrae is a must for safe and effective surgery of the region. Although there are several clinical studies of transpedicular fixation, few studies have been performed on cervical pedicle measurements and their projection. METHODS: In 29 dried bone cervical spinal columns (C3-C7), pedicle dimensions (pedicle height, width, length), measurements of lateral mass and pedicle length distance and pedicle axis length, investigation of distances of superior facet-midpedicle axis and inferior facet-midpedicle axis, and transverse and sagittal angles of the pedicles were performed in linear and angular measurements. RESULTS: The obtained data from the series revealed that the mean values were approximately ranging from 6.7 to 7.2 mm for pedicle height, 4.4 to 4.9 mm for pedicle width, 5.3 to 6.2 mm for pedicle length, 15.3 to 16.0 mm for lateral mass and pedicle length, 22.2 to 27.7 mm for pedicle axis length, 3.8 to 5.3 mm for superior facet-midpedicle axis distance, 9.9 to 12.0 mm for inferior facet-midpedicle axis distance, 42.3 degrees to 51.5 degrees for transverse angle, and 5.2 degrees to 14.1 degrees for sagittal angle. CONCLUSIONS: Linear measurements of pedicle dimensions and also axial angles from horizontal and vertical planes may provide some anatomic limitations for subaxial cervical transpedicular screw fixation, and also contribute to the safety of the surgical procedure. One should also rely on tomographic data and computer-assisted guidance systems.

Anthropometry↗
PubMed2002

[Self migrating intracranial bullets].

We report herein two patients in whom bullets migrated into adjacent lateral ventricles in the brain and moved freely as a consequence of gravity. A rewiew ofthe literature suggests that spontaneous migration ofintracerebral bullets is being eased by cerebral softness, specific gravity of the bullet compared with brain tissue. ln patients undergoing the surgical removal of intracerebral or intraventricular bullets, an x-ray is recommended after final positioning.

Brain↗