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Biomedical subjects

Mostafa Saadat

Publications and source records attributed to Mostafa Saadat.

26 records · Page 2Linked to original sources
PubMed2004

Alterations in blood pressure due to chronic exposure to natural sour gas leakage containing sulfur compounds.

In order to show the alteration of blood pressure in subjects chronically exposed to natural gas containing sulfur compounds, the present study was done. The blood pressure of 94 (43 males, 51 females) of healthy individuals living in the polluted area of Masjid-i-Sulaiman (Khozestan province, southwest of Iran) was measured. The non-parametric Sign test was applied in order to detect differences between the study subjects and the normal mean values according to the sex and age of subjects. Statistical analysis showed that the systolic blood pressure significantly decreased (Z=-2.74; P=0.0031) while the diastolic blood pressure (Z=+2.11; P=0.0174) and heart rate (Z=+3.62; P<0.001) significantly increased in individuals living in the contaminated areas compared with those of normal mean values. The systolic and diastolic blood pressure decreased and increased, respectively, in individuals chronically exposed to natural sour gas containing sulfur compounds.

Blood Pressure↗
PubMed2004

High incidence of suicide by burning in Masjid-i-Sulaiman (southwest of Iran), a polluted area with natural sour gas leakage.

Masjid-i-Sulaiman (MIS) is located in the southwest of Iran. Unfortunately, some parts of MIS are contaminated by subsurface leakage of natural gas containing H(2)S. In order to investigate the possible effect(s) of chronic exposure to sulfur compounds on suicidal behavior, the present study was done. In the 2-year period, 561 individuals attempted suicide (260 men and 301 women). Completed suicide comprised of 19 men and 32 women. The rate per 100,000 person-years was 19.9 for men and 34.8 for women aged over 15 years. Forty-two (13 men and 29 women) of 561 patients were self-immolators by fire with a male:female ratio 0.45. This represents 22.4 burns per 100,000 person-years and is equivalent to 7.4% of all suicide attempts. Thirty-three of 42 patients died (78.6%) who were 9 men and 24 women with male:female ratio 0.37. There is statistically significant differences between sex groups (P((2)) = 0.0091). The self-inflicted burn was the most frequent method for lethal suicide. Winter was the most common season for self-burning followed by spring. Statistical analysis showed significant difference between seasons for self-inflicted burn (P((2)) = 0.00001). Analysis of correlation showed statistically positive correlation coefficient between mean values of all reactive sulfur compounds and seasonal frequency of suicide (r = 0.923, P((1)) = 0.038).

Adult↗
PubMed2004

Hematological changes due to chronic exposure to natural gas leakage in polluted areas of Masjid-i-Sulaiman (Khozestan province, Iran).

An overwhelming number of studies have given consistent findings that environmental or occupational exposure to oil products results in a significant decrease in circulating erythrocytes, hemoglobin, platelets, total white blood cells, and absolute numbers of lymphocytes and neutrophils. Some parts of Masjid-i-Sulaiman (located in the southwest of Iran) are contaminated by subsurface leakage of natural gas, which contains a high level of hydrogen sulfide. The amount of all reactive sulfur compounds in air of contaminated areas of MIS was estimated as equal to 0.023+/-0.002 ppm of SO(2). In the present report the hematological findings of 99 persons from polluted areas of MIS were compared with those of 396 individuals from the general population of MIS matched by age (+/-3 years) and sex. The CBC test and the WBC differential were analyzed in one central laboratory according to standard hematological methods, by Coulter S (Biomedical). The multiple linear regression method was applied in order to detect differences among exposed and unexposed groups for hematological markers. The absolute mean number of red blood cells, percentages of hematocrit, level of hemoglobin, and absolute number of platelets were significantly higher among the exposed subjects compared with the control group. However, the absolute mean numbers of white blood cells, lymphocytes, and neutrophils were significantly decreased in the exposed group compared with the control.

Adolescent↗
PubMed2004

Polymorphisms of glutathione S-transferases M1 and T1 do not account for interindividual differences for smoking behavior.

To identify whether the polymorphisms of glutathione S-transferase M1 (GSTM1) and GSTT1 genes predict a high-tended risk of using tobacco, the GSTM1 and GSTT1 genotypes of 369 Iranian males (254 nonsmokers and 115 smokers) and 314 Iranian females (245 nonsmokers and 69 smokers) were determined. The frequencies of GSTM1 (males: OR=0.98, 95% CI=0.62-1.57, P=.974; females: OR=1.34, 95% CI=0.75-2.39, P=.358) and GSTT1 (males: OR=1.25, 95% CI=0.76-2.04, P=.412; females: OR=0.84, 95% CI=0.46-1.51, P=.626) null genotypes were similar in nonsmokers and smokers. The risk of being a smoker was to be equally frequent in each combination of the genotypes. The present results revealed that there was no difference between smokers and nonsmokers for these two genetic polymorphisms.

Adult↗
PubMed2003

Modulation of hematology changes by polymorphism of glutathione S-transferase M1 and T1.

Workers in the petroleum distribution trades experience relatively low-level exposures to gasoline vapors whose consequences have not been fully elucidated. The purpose of this study was to investigate changes in the hematological parameters among filling station workers who were occupationally exposed to gasoline. The target group for the study consisted of 41 workers from eight filling stations of Shiraz (south of Iran). The control group consisted of 27 healthy subjects matched for age and sex from general population. The complete blood count analysis was done in one laboratory. Using PCR-based method, the genotypes of glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) were determined. Workers were divided into three exposure groups according to employment history: duration less than 1 year, 1-5 years, and more than 5 years. Comparison was performed using Kruskal-Wallis test. In the individuals with the presence of both GSTT1 and GSTM1 functional alleles, comparison between four exposure groups revealed no significant difference for studied hematological variables. There were statistically significant differences between study groups, with only one functional allele, either GSTT1 or GSTM1, for relative number of lymphocytes (chi(2)=9.147, df=3, P=0.027) and neutrophils (chi(2)=9.951, df=3, and P=0.019), and absolute number of lymphocytes (chi(2)=9.135, df=3, and P=0.028), and RBC (chi(2)=10.586, df=3, and P=0.014). These findings could indicate the possible protective effect of concurrent presence of GSTM1 and GSTT1 enzymes on the hematopoietic system of filling station workers.

Adult↗
PubMedDate not supplied

Offspring sex ratio is not associated with parental GSTT1 and GSTM1 null genotypes.

The present study evaluated the association between offspring sex ratio and parental inherited variations of xenobiotic metabolism by glutathione S-transferase (GST) T1 and GSTM1. Polymorphisms of GSTT1 and GSTM1 were investigated in 235 Iranian Muslims (153 males, 82 females) using polymerase chain reaction-based method. Statistical analysis of 890 offspring in the study families revealed that there was no association between GSTM1 null genotype of either the fathers (OR=1.28; 95% CI=0.88-1.85; P=0.17) or mothers (OR=0.77; 95% CI=0.49-1.19; P=0.22) and offspring sex ratio. There was no association between paternal GSTT1 null genotype and sex ratio in offspring (OR=1.04; 95% CI=0.71-1.54; P=0.84), whereas there was a weak association between maternal GSTT1 null genotype and offspring sex ratio (OR=1.54; 95% CI=1.0-2.38; P=0.05). Combination of parental GSTT1 and GSTM1 genotypes showed no association with offspring sex ratio.

Female↗