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Biomedical subjects

Mitchell E Berman

Publications and source records attributed to Mitchell E Berman.

8 recordsLinked to original sources

Familial association of anxiety sensitivity and psychopathology.

The purpose of this study was to examine the association between parental (biological mother and father) and adult-offspring anxiety sensitivity (AS), and to determine whether parental AS is related to psychopathology in offspring. We obtained offspring (N=174) self-ratings of anxiety, mood, and stress symptoms, and assigned psychiatric diagnoses using a semistructured clinical interview. Biological mothers, fathers, and offspring independently completed a self-report measure of AS. We hypothesized that (1) there would be a positive relation between parental and offspring AS, and (2) AS in parents would be positively associated with psychopathology in offspring. Results indicated that paternal (but not maternal) AS was associated with offspring AS and psychopathology.

Adult↗

Skew and internal consistency.

The effects of skew on the standardized item alpha were examined with Monte Carlo techniques. Alphas computed from normal variables were compared with alphas from lognormal variables, ranks, and skewed versus normal Likert-type variables. The extent and direction of skew were varied, as was the size of the population interitem correlation (rho), the number of items, and the number of categories for Likert-type variables. Because the average interitem correlation affects alpha and skew affects the average interitem correlation, the effect of skew on the average interitem correlation also was examined. Results indicated that skew decreased the average interitem correlation and produced small decreases in alpha that were largest when skew was large, rho was small, items were skewed in opposite directions, and there were fewer items.

Humans↗

Intermittent explosive disorder-integrated research diagnostic criteria: convergent and discriminant validity.

Research on intermittent explosive disorder (IED) has been hindered by vague and restrictive DSM-IV diagnostic criteria. Integrated research criteria have been developed for IED (IED-IR) that address the DSM-IV criteria's shortcomings. The purpose of this study was to examine the convergent and discriminant validity of the IED-IR criteria set by comparing adults meeting these criteria (n=56) to healthy controls (n=56) and to individuals with an Axis I major mental disorder (n=33) or an Axis II personality disorder (n=22) diagnoses on measures of aggression (self-report and behavioral) and global functioning. IED-IR individuals demonstrated higher levels of aggression compared to the other three groups, and were rated as more impaired than the healthy control and Axis I individuals. Subgroup analyses showed that IED-IR subjects who did not meet DSM IED criteria did not differ from DSM IED subjects on self-report measures of aggressiveness or global functioning. Furthermore, the IED-IR subjects evidenced more behavioral aggression than their DSM-IED counterparts.

Adolescent↗

The effects of diazepam on human self-aggressive behavior.

RATIONALE: Diazepam, a benzodiazepine with a relatively rapid onset of clinical effects, has been associated with suicide and other self-aggressive acts. The evidence for this association, however, comes exclusively from retrospective non-experimental studies. Although suggestive, the results of these studies do not support a cause-and-effect relationship between benzodiazepine consumption and self-aggressive behavior. OBJECTIVE: To experimentally examine the effect of diazepam on human self-aggressive behavior under controlled laboratory conditions. METHOD: Forty-six healthy men and women were randomly assigned to receive placebo, or 5 mg or 10 mg diazepam in a double-blind, between-groups design. Participants were then provided the opportunity to self-administer electric shocks during a competitive reaction-time task (the self-aggression paradigm, SAP). Self-aggression was defined by the intensity of shock chosen. RESULTS: Diazepam (10 mg) was associated with higher average shock self-administered than placebo. Subjects receiving 10 mg diazepam were also more likely to attempt to self-administer a shock that they were led to believe was "severe" and painful. Sedation effects were found, but diazepam consumption did not impair memory, attention, concentration, pain threshold, or reaction-time performance. CONCLUSIONS: Clinically relevant diazepam doses may be associated with self-aggressive behaviors at levels that do not significantly impair basic cognitive processes or psychomotor performance.

Adult↗

Effects of aerobic exercise on anxiety sensitivity.

Anxiety sensitivity is a known precursor to panic attacks and panic disorder, and involves the misinterpretation of anxiety-related sensations. Aerobic exercise has been shown to reduce generalized anxiety, and may also reduce anxiety sensitivity through exposure to feared physiological sensations. Accordingly, 54 participants with elevated anxiety sensitivity scores completed six 20-min treadmill exercise sessions at either a high-intensity aerobic ( n = 29 ) or low-intensity ( n = 25 ) level. Self-ratings of anxiety sensitivity, fear of physiological sensations associated with anxiety, and generalized anxiety were obtained at pre-treatment, post-treatment, and one-week follow-up. Results indicated that both high- and low-intensity exercise reduced anxiety sensitivity. However, high-intensity exercise caused more rapid reductions in a global measure of anxiety sensitivity and produced more treatment responders than low-intensity exercise. Only high-intensity exercise reduced fear of anxiety-related bodily sensations. The implications of these findings are discussed.

Adolescent↗

Alcohol intoxication and self-aggressive behavior.

Nonexperimental field studies have demonstrated an association between alcohol intoxication and self-aggressive behaviors across the spectrum of lethality. Although these results are suggestive, it is not yet known whether alcohol intoxication is causally related to self-aggression. The authors therefore experimentally examined the effects of alcohol intoxication (mean blood alcohol concentration of .10) on a behavioral measure of self-aggression in men (N = 40). After consuming either an alcohol or a placebo drink, participants were provided the opportunity to self-administer shock during a task disguised as a reaction-time game, with self-aggression defined by the intensity of shock chosen. Half of the participants observed a self-aggressive model (a potential moderator of alcohol-related self-aggression). Independent alcohol and model effects were found, with alcohol accounting for over 30% of the self-aggression variance.

Adult↗

Diverse research on alcohol and aggression in humans: in memory of John A. Carpenter.

This article summarizes the proceedings of a symposium, chaired and co-organized by Helene Raskin White and co-organized by Peter R. Giancola, that was presented at the 2002 RSA Meeting in San Francisco. The goal of this symposium was to integrate findings from methodologically divergent studies on the topic of alcohol-related aggression in humans. The investigators focused on isolating mediators and moderators of the alcohol-aggression relationship. Peter R. Giancola presented laboratory data demonstrating how alcohol's acute effects on aggression are moderated by individual difference and contextual factors. Mitchell E. Berman presented laboratory data on alcohol's acute effects on self-induced aggression. Helene Raskin White reviewed prospective data on how alcohol affects the intergenerational transmission of family violence. Stephen Chermack reviewed data on the impact of a family history of alcoholism and a family history of violence on the development of childhood behavioral problems and adult problems with drugs, alcohol, and violence. Finally, Kenneth E. Leonard presented data on personal and contextual factors influencing alcohol-related barroom violence.

Adult↗