Biomedical subjects
Mingcai Qiu
Publications and source records attributed to Mingcai Qiu.
[Treatment of hyperthyroid atrial fibrillation associated with Graves disease by prednisone].
OBJECTIVE: To investigate the clinical effect of prednisone on hyper thyroid atrial fibrillation associated with Graves disease (HAFGD). METHODS: Twenty-four patients with hyperthyroid atrial fibrillation associated with Graves disease were divided into two groups: traditional antithyroid group (10 cases, with 2 males and 8 females, treated by methimazole 15 approximately 30 mg/d and propranolol 15 approximately 30 mg/d) and prednisone group (14 cases with 3 males and 11 females, treated by methimazole 15 approximately 30 mg/d, propranolol 15 approximately 30 mg/d, and prednisone 30 mg/d). The effects of these two remedies on reversion from atrial fibrillation to sinus rhythm were compared. RESULTS: The cardiac rhythm reverted to sinus rhythm in 12 out of the 14 cases in prednisone group with a reversion rate of 86% and the mean reversion time of 3.8 months (range 3.8 +/- 2.6 months), and in 4 out of the 10 cases in traditional antithyroid remedy group with the mean reversion rate of 40% and mean reversion time of 2.8 months (range 2.8 +/- 1.0 months). The reversion rate was significantly higher in prednisone group than in the traditional remedy group (P < 0.05). CONCLUSION: Treatment of prednisone is more beneficial to reversion of atrial fibrillation into sinus rhythm among patients with HARGD.
[Effect of serum from patients with Graves' disease on colony forming unit-granulocyte monocyte].
OBJECTIVE: To investigate the effects of serum component from patients with Graves's disease (GD) on the growth of colony forming unit-granulocyte monocyte (GM-CFU). METHODS: Monocytes were obtained from 11 normal persons and 11 GD patients with leukopenia and culture together with sera from 11 GD patients with leukopenia, 11 GD patients without leukopenia, and 11 normal controls for 10 days. Inverted microscopy was used to count the number of colony. RESULTS: Thyroid stimulating immunoglobulin (TSI) and serum from GD patients with leukopenia significantly inhibited the formation of GM-CFU (P < 0.01) while methimazole, thyroxine and serum from GD patients without leukopenia did not have any effect on the formation of GFU-GM (P > 0.05). CONCLUSION: TSI and serum from GD patients with leukopenia remarkably inhibit GM-CFU growth. Autoimmune abnormality may play an important role in the pathogenesis of leukopenia in patients with GD.
Allele A in intron 4 of ecNOS gene will not increase the risk of diabetic nephropathy in type 2 diabetes of Chinese population.
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[Association of ecNOS 4 b/a polymorphism and end-stage chronic renal failure].
OBJECTIVE: To examine the association between insertion/deletion polymorphism in intron 4 of ecNOS gene (ecNOS 4 b/a) and end-stage chronic renal failure (ESCRF) in Han people in Tianjin, China. METHODS: The genotypes of ecNOS 4 b/a polymorphism were detected by PCR-minisatellite DNA detection technique. 67 CRF patients on hemodialysis were included in the study group, with 70 healthy volunteers as controls. RESULTS: (1) The genotype frequencies were 79.1%, 19.4% and 1.5% in the patients and 91.4%, 8.6% and 0% in the controls for bb, ba and aa genotypes, respectively. (2) The allele frequencies were significantly different between the patients and controls (chi(2) = 4.617, P < 0.05). The a/(a + b) odds ratio (OR, 95% confidence interval) of the patients vs controls was 2.64 (1.09, 6.43) (Z = 2.14, P < 0.05). (3) The average age of the patients with allele a was 47.43 +/- 11.63, while that without allele a was 58.08 +/- 13.68. The difference was significant, t = 2.664 (P < 0.01). (4) The frequency of allele a is lower in Han people of Tianjin (4.3%) than that in Japanese (10.1%) (chi(2) = 4.898, P = 0.027). CONCLUSIONS: (1) The frequency of allele a is lower in Han people of Tianjin than that in Japanese and Westeners; (2) ecNOS 4 b/a polymorphism is associated with ESCRF in Han population of Tianjin and allele a is associated with the increased risk of ESCRF.