Biomedical subjects

Ming Jiang

Publications and source records attributed to Ming Jiang.

78 records · Page 5Linked to original sources

PubMed2002

[Fat at sacroiliac joints: MR imaging findings (comparison and analysis of 18 volunteers and 52 patients with ankylosing spondylitis)].

OBJECTIVE: In aid of MR imaging diagnosis of ankylosing spondylitis (AS), MRI findings of sacroiliac (SI) joints in volunteers were compared with those in patients with AS, with special reference to the fat findings. METHODS: 18 normal volunteers and 52 AS patients underwent the MRI examinations with the same protocols, i.e., SE T1WI, FSE T2WI, GE T2*WI sequences were taken using a 0.3T imager. All the images were observed and analyzed by two radiologists. RESULTS: Symmetric or patchy distribution fat component either in sacrum and/or ilium was detected in 52.8% of SI joints of volunteers. Thin zone distribution of fat was seen in 35.6% of SI joints of AS patients, which was adjacent to the erosion and sclerosis. In another 25.0% of SI joints of AS patients, the distribution of fat component was found similar to that of the normal volunteers. Cartilage changes were detected in 85.6% of the SI joints of AS patients. In addition, bone erosion, sclerosis and subchondral bone marrow edema were also detected. CONCLUSION: Subchondral fat infiltration associated with erosion and sclerosis should be considered as sacroiliitis. The knowledge of the characteristics of fat component could be helpful for evaluating sacroiliac joints.

Adipose Tissue↗

PubMedDate not supplied

Structural transformation of cytochrome c and apo cytochrome c induced by sulfonated polystyrene.

The structural transformation of cytochrome c (cyt c) and its heme-free precursor, apo cyt c, induced by negatively charged sulfonated polystyrene (SPS) with different charge density (degree of sulfonation) and chain length was studied to understand the factors that influence the folding and unfolding of the protein. SPS forms stable transparent nanoparticles in aqueous solution. The hydrophobic association of the backbone chain and phenyl groups is balanced by the electrostatic repulsion of the sulfonate groups on the particle surface. The binding of cyt c to negatively charged SPS particles causes an extensive disruption of the native compact structure of cyt c: the cleavage of Fe-Met80 ligand, about 40% loss of the helical structure, and the disruption of the asymmetry environment of Trp59. On the other hand, SPS particle-bound apo cyt c undergoes a conformational change from the random coil to alpha-helical structure. The folding of apo cyt c in SPS particles was influenced by pH and ionic strength of the solution, SPS concentration, and the degree of sulfonation and chain length of SPS. The folding can reach more than 90% of the alpha-helix content of native cyt c in solution. Poly(sodium 4-styrenesulfonate) (PSS), which is 100% sulfonated polystyrene and cannot form hydrophobic cores in the solution, induces only two-thirds of the alpha-helix content compared with SPS. It appears that the electrostatic interaction between PSS/SPS and apo cyt c induces an early partially folded state of apo cyt c. The hydrophobic interaction between nonpolar residues in apo cyt c and the hydrophobic cores in SPS particles extends the alpha-helical structure of apo cyt c.

Animals↗

PubMedDate not supplied

Structural transformation of apocytochrome c induced by alternating copolymers of maleic acid and alkene.

Apocytochrome c interacts with two copolymers: poly(isobutylene-alt-maleic acid) (PIMA) and poly(1-tetradecene-alt-maleic acid) (PTMA). The interaction leads to apocytochrome c, a conformational change from random coil to alpha-helical structure. The alpha-helix content is influenced by the copolymer concentration, the length of alkyl chain of the copolymers, and pH of the medium. The electrostatic attraction between the copolymer and protein is an indispensable factor for the folding of the protein at acid pH. The hydrophobic interaction is an important factor over the entire pH range, especially when both the copolymer and protein carry negative charges at alkaline pH. The electrostatic and hydrophobic attractions between the copolymer and protein exclude water molecules, promoting the formation of hydrogen bonds within the helical structure. On the other hand, the hydrogen bonds formed between the ionized carboxyl of the copolymer and the amide of the protein partly restrain the formation of hydrogen bonds within the helical structure when the copolymer concentration is higher at pH 6.5 and 10.5.

Alkenes↗

PubMedDate not supplied

Spatial domain wavelet design for feature preservation in computational data sets.

High-fidelity wavelet transforms can facilitate visualization and analysis of large scientific data sets. However, it is important that salient characteristics of the original features be preserved under the transformation. We present a set of filter design axioms in the spatial domain which ensure that certain feature characteristics are preserved from scale to scale and that the resulting filters correspond to wavelet transforms admitting in-place implementation. We demonstrate how the axioms can be used to design linear feature-preserving filters that are optimal in the sense that they are closest in L2 to the ideal low pass filter. We are particularly interested in linear wavelet transforms for large data sets generated by computational fluid dynamics simulations. Our effort is different from classical filter design approaches which focus solely on performance in the frequency domain. Results are included that demonstrate the feature-preservation characteristics of our filters.

Algorithms↗

PubMedDate not supplied

Vortex visualization for practical engineering applications.

In order to understand complex vortical flows in large data sets, we must be able to detect and visualize vortices in an automated fashion. In this paper, we present a feature-based vortex detection and visualization technique that is appropriate for large computational fluid dynamics data sets computed on unstructured meshes. In particular, we focus on the application of this technique to visualization of the flow over a serrated wing and the flow field around a spinning missile with dithering canards. We have developed a core line extraction technique based on the observation that vortex cores coincide with local extrema in certain scalar fields. We also have developed a novel technique to handle complex vortex topology that is based on k-means clustering. These techniques facilitate visualization of vortices in simulation data that may not be optimally resolved or sampled. Results are included that highlight the strengths and weaknesses of our approach. We conclude by describing how our approach can be improved to enhance robustness and expand its range of applicability.

Journal Article↗

PubMedDate not supplied

A research on the relationship between ejaculation and serum testosterone level in men.

The purpose of this study is to gain understanding of the relationship between ejaculation and serum testosterone level in men. The serum testosterone concentrations of 28 volunteers were investigated daily during abstinence periods after ejaculation for two phases. The authors found that the fluctuations of testosterone levels from the 2nd to 5th day of abstinence were minimal. On the 7th day of abstinence, however, a clear peak of serum testosterone appeared, reaching 145.7% of the baseline ( P < 0.01). No regular fluctuation was observed following continuous abstinence after the peak. Ejaculation is the precondition and beginning of the special periodic serum testosterone level variations, which would not occur without ejaculation. The results showed that ejaculation-caused variations were characterized by a peak on the 7th day of abstinence; and that the effective time of an ejaculation is 7 days minimum. These data are the first to document the phenomenon of the periodic change in serum testosterone level; the correlation between ejaculation and periodic change in the serum testosterone level, and the pattern and characteristics of the periodic change.

Adult↗