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Biomedical subjects

Ming H Jih

Publications and source records attributed to Ming H Jih.

32 records · Page 2Linked to original sources
PubMed2004

Successful treatment of a chronic atrophic dog-bite scar with the 1450-nm diode laser.

BACKGROUND: Atrophic scars can be revised with surgical methods and more recently with newer ablative and nonablative laser techniques. Nonablative laser technology offers the advantage of improving the appearance of atrophic scars without the risks associated with traditional surgery or ablative lasers. METHODS: A case of a large linear atrophic dog-bite scar on the chin of greater than 2-year duration treated for three sessions at 4- to 6-week intervals with the 1450-nm diode laser is presented. RESULTS: Fifty to seventy-five percent improvement in the appearance of the scar resulted after three treatments with the 1450-nm diode laser. No adverse effects were noted from the treatment. The patient subjective rating of scar improvement was more than 50%. CONCLUSION: The 1450-nm diode laser may provide a noninvasive and effective alternative for the treatment of atrophic traumatic scars. This method appears to be potentially effective even for treatment of very mature scars and warrants additional studies.

Adult↗
PubMed2004

Mohs micrographic surgery for elliptical excision of skin tumors: a surgical and histologic study.

BACKGROUND: Elliptical excision is a standard form of treatment for cutaneous neoplasms, but routine pathologic sectioning results in incomplete histologic control of surgical margins. OBJECTIVE: The objective was to describe a technique of complete histologic margin control for tumors removed by excision as an ellipse. METHODS: A retrospective study of 100 consecutive nonmelanoma skin cancers of the head and neck removed using elliptical excisions with complete histologic margin control was performed. The technique is described and depicted in detail. RESULTS: Seventy-one tumors were removed in one excision, and 29 required additional excisions for complete histologic tumor clearance. Linear repairs were used for 93 tumors. CONCLUSION: Elliptical excision, combined with our technique of complete histologic margin control, provides a simple, efficient, and effective method for surgical removal and repair of nonmelanoma skin cancers and provides an alternative variation of performing Mohs micrographic surgery for selected tumors.

Female↗
PubMed2004

Perioperative primary stroke: is aspirin cessation to blame?

BACKGROUND: There are a number of reports in the literature of patients developing thrombotic events after stopping medically necessary antiplatelet and antithrombotic agents. OBJECTIVE: The objective was to determine whether discontinuation of aspirin taken for primary prophylaxis contributes to the development of thrombotic complications in patients undergoing dermatologic surgery. METHODS: A case is reported and the literature is reviewed. RESULTS: We present the first reported case of a postoperative thrombotic event following dermatologic surgery in a patient withholding aspirin that was taken for primary prophylaxis. CONCLUSION: We believe that the available data make it difficult to implicate aspirin discontinuation in the development of each thrombotic event, given the high baseline risk of thrombotic events in the Mohs surgery patient population and the low risk of developing such events when medications are withheld perioperatively.

Aged↗
PubMed2003

Klippel-Trenaunay syndrome.

A 28-year old woman with extensive right-leg capillary malformation associated with limb hypertrophy and limb-length discrepancy consistent with Klippel-Trenaunay syndrome is presented. Treatment with the new long-pulsed-dye lasers may lead to improvement of the superficial hemangioma component of the affected areas.

Adult↗
PubMed2003

Porokeratosis plantaris, palmaris, et disseminata.

A 66-year-old woman presented with thick, hyperkeratotic papules and plaques on the plantar aspects of both feet as well as more superficial, annular, hyperkeratotic papules on the chest, neck, and face. A biopsy was consistent with porokeratosis. The clinical findings are consistent with porokeratosis plantaris, palmaris, et disseminata.

Aged↗
PubMed2002

The molecular basis of hereditary palmoplantar keratodermas.

In recent years, the gene defects causing many types of hereditary palmoplantar keratoderma have been discovered. These genes encode a variety of proteins involved in the terminal differentiation of keratinocytes and the formation of the cornified cell envelope. In this article, we review the molecular defects underlying various palmoplantar keratodermas with particular attention to the role of these molecules in the terminal differentiation of palmoplantar epidermis. Of the proteins involved in keratodermas, loricrin, keratins, and desmosomal proteins provide the protein structure of the cornified cell envelope. Connexins form intercellular gap junctions, which regulate ionic calcium signals necessary for the expression of the proteins that form the cornified cell envelope. Cathepsins likely mediate enzymatic processes necessary for the formation and dissolution of the cornified cell envelope. The clinical phenotypes produced by various mutations affecting these proteins are discussed vis-à-vis data from genetic, cellular, and molecular experiments.

Animals↗
PubMed2002

Reversal reaction to Hansen's disease.

A 25-year-old man with a history of mid-borderline (BB) Hansen's disease developing a reversal reaction after starting dapsone and rifampin therapy is presented. His clinical features included erythematous, edematous plaques and peripheral neuropathy. Reversal reactions are caused immunologically by enhanced cell-mediated (Th-1) immunity to Mycobacterium leprae, resulting in inflammation of infected tissues, such as skin and nerves. Acute neuritis can lead to permanent nerve damage and necessitate prompt treatment with prednisone and/or clofazamine.

Adult↗
PubMedDate not supplied

Keratoacanthoma arising from an excisional surgery scar.

A causal relationship between keratoacanthomas and a variety of preceding traumatic events has been postulated in the literature. We report a patient who developed a keratoacanthoma at the site of a recent cutaneous excision site, demonstrating that surgical trauma can precede the development of keratoacanthomas.

Aged↗