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Biomedical subjects

Minas Coroneo

Publications and source records attributed to Minas Coroneo.

4 recordsLinked to original sources
PubMed2005

Intraocular contact lens tamponade to facilitate penetrating keratoplasty in perforated corneas.

Penetrating keratoplasty in the presence of a perforated cornea is a relatively common and difficult surgical problem. In the worst scenario, there may be extrusion of ocular contents during trephination. Two cases of perforated corneas are presented in which a new technique was used to close the perforation and normalize intraocular pressure. This involves inserting a soft contact lens through a paracentesis into the anterior chamber. An ophthalmic viscosurgical device is then injected behind the contact lens, opening it, and allowing it to tamponade the perforation. This stabilizes the anterior chamber and allows a stable operating environment. This has not been described previously.

Aged↗
PubMed2005

Epidermal growth factor receptor signaling is partially responsible for the increased matrix metalloproteinase-1 expression in ocular epithelial cells after UVB radiation.

Pterygia are inflammatory, invasive, and proliferative lesions of the human ocular surface in which the matrix metalloproteinase (MMP) collagenase-1 (MMP-1) is highly expressed. Pterygia development may involve MMP-1 activity against interstitial fibrillar collagen, an abundant extracellular matrix component of the cornea, and its induction by ultraviolet light (UVB). We examined the pathways responsible for enhanced expression of MMP-1 in pterygium epithelial cells after UVB exposure and/or treatment with chemical inhibitors of mitogen-activated protein kinases or epidermal growth factor receptor. The induction of MMP-1 by UVB was comparable to that mediated by heparin-binding epidermal growth factor-like growth factor and epidermal growth factor. The epidermal growth factor receptor inhibitor PD153035 partially blocked the UVB-mediated induction of MMP-1 and totally abrogated its production after stimulation with either heparin-binding epidermal growth factor-like growth factor or epidermal growth factor. UVB exposure enhanced the phosphorylated form of ERK1/2 in a time-dependent manner whereas the ERK1/2 inhibitor PD98059 decreased this induction by at least fivefold. Transcripts for c-jun and c-fos were detected as early as 2 hours after UVB exposure and were suppressed by PD98059. The identification of a specific intracellular signaling pathway responsible for the enhanced production of a key enzyme that denatures intact fibrillar collagen has important implications for understanding the pathophysiology and future therapy for pterygia.

Blotting, Western↗
PubMed2005

Teleophthalmology-assisted corneal foreign body removal in a rural hospital.

This paper describes two cases of using telementoring from the Prince of Wales Hospital (POWH) Ophthalmology Department, Sydney, to Bourke Base hospital, a rural hospital in far west New South Wales, Australia. Eye trauma occurs frequently in a rural setting, and it can be difficult to assess the extent of the injury without a specialist ophthalmic service. One of the aims of the teleophthalmology is to facilitate the transfer of ophthalmic skills to local health providers such as general practitioners. We demonstrate that the removal of corneal foreign bodies and rust rings can be effectively supervised via teleophthalmology.

Adult↗