Biomedical subjects

Miin-Fu Chen

Publications and source records attributed to Miin-Fu Chen.

95 records · Page 6Linked to original sources

PubMedDate not supplied

Sclerosing hepatocellular carcinoma: clinicopathologic features in seven patients from Taiwan and review of the literature.

BACKGROUND/AIMS: Sclerosing hepatocellular carcinoma (HCC) is an uncommon subtype of HCC. We provided data on 7 cases of sclerosing HCC, including clinical presentations, diagnoses, management, and prognoses. METHODOLOGY: A retrospective review of the medical records of seven patients with sclerosing HCC treated at Chang Gung Memorial Hospital-Taipei between Oct 1994 and Jan 2001. RESULTS: Seven patients with sclerosing HCC were identified, with ages ranging from 26 to 71 years (mean, 42.3 years). Abdominal fullness was the most common symptom, occurring in 4 of seven patients (57.1%). All seven patients with sclerosing HCC had normal serum calcium and phosphate values. HCC was the most common preoperative diagnosis, occurring in 5 of seven patients (71.4%). Three of the seven patients were correctly diagnosed with sclerosing HCC preoperatively. The median overall survival and disease-free survival of these seven patients were 20 and 9 months, respectively. CONCLUSIONS: In Taiwan, the patients with sclerosing HCC had normal serum values of calcium and phosphate. Sclerosing HCC has specific, but different radiological and pathological features, compared with conventional HCC. Its prognosis does not seem poor, although we still need to follow-up for a longer period.

Adult↗

PubMedDate not supplied

Long-term survival following resection of peritoneal implantation from hepatocellular carcinoma: a case report.

This study presents a rare case of long-term survival following the resection of peritoneal implantation from hepatocellular carcinoma (HCC). A 33-year-old female patient with hepatitis B infection presented with a huge pedunculated HCC and underwent left lateral segmentectomy in 1995. She received regular follow-up and peritoneal implantation was diagnosed 30 months after hepatic resection using abdominal computed tomography due to elevated alpha-fetoprotein (AFP). Subsequently, the patient received segmental resection of jejunum and a solitary peritoneal implantation from HCC in the mesentery of the jejunum. No peritoneal carcinomatosis, direct invasion of the surrounding tissue, or lymph node involvement existed and the postoperative course was uneventful. Meanwhile, histopathological examination of the resected nodule revealed metastatic hepatocellular carcinoma. With regular follow-up with AFP, abdominal ultrasonography, and or computed tomography, no intrahepatic tumor recurrence or extrahepatic metastasis was observed. The patient survived for 90 months following hepatic resection, and survived disease free for 60 months after resection of peritoneal implantation from HCC.

Adult↗

PubMedDate not supplied

Effects of dopexamine on regional blood flow and leukotriene production in multiple splanchnic sites in endotoxemic rats.

BACKGROUND/AIMS: This work examines the effects of lipopolysaccharide (LPS) on splanchnic blood flow and tests the potential effect of dopexamine in preventing LPS-induced decrease in splanchnic blood flow, also analyzing its influence on regional leukotriene production. METHODOLOGY: Male Sprague-Dawley rats were grouped and subjected to i.v. administration (time 0) of the lipopolysaccharide (10mg/kg) or vehicles with some rats receiving dopexamine (2microg/kg/min) (times 2 hrs to 6 hrs) infusion and compared. Microdialysis collection for analyzing leukotrienes concentrations and direct splanchnic laser Doppler flowmetry were started at times 0 to 6 hrs. RESULTS: Mean arterial pressure decreased markedly in LPS-injected animals and it decreased further gradually during observation period. A marked increase in mean arterial pressure was noted following concomitant administration of dopexamine with LPS. CONCLUSIONS: Impaired splanchnic blood flow in the stomach, jejunum and ileum after LPS injection has been attenuated following infusion of dopexamine. The changes in regional blood flow in the specific splanchnic area correlate closely with the systemic mean arterial pressure in this early sepsis model. Increased leukotriene production following LPS injection also has been attenuated in the stomach, jejunum and ileum following dopexamine infusion, and the increase of leukotriene production also correlates closely with systemic mean arterial pressure.

Animals↗

PubMedDate not supplied

Lower gastrointestinal bleeding due to small bowel metastasis from leiomyosarcoma in the tibia.

Small bowel metastasis from primary bone leiomyosarcoma is very rare. Here we report on a 50-year-old man who presented with general weakness, weight loss (six kg in two months) and intermittent tarry stools for two months. He had undergone an above-knee amputation for left tibia leiomyosarcoma seven years previously. No local recurrence and/or distant metastasis developed during a seven-year period of follow-up. Subsequent imaging study revealed a multilobulated mass in the ileum. He received segmental resection of the small bowel and a multilobulated mass was noted in the submucosal layer of the ileum with mucosa ulceration. His postoperative course was uneventful. Histopathological examination of the resected mass revealed small bowel metastatic leiomyosarcoma. No local recurrence or distant metastases were detected during a six-month follow-up period. To the best of our knowledge, this is the first report of small bowel metastasis from primary bone leiomyosarcoma presenting with lower gastrointestinal bleeding.

Bone Neoplasms↗

PubMedDate not supplied

Radioguided sentinel lymph node biopsy in early breast cancer: experience at Chang Gung Memorial Hospital.

BACKGROUND: Sentinel lymph node (SLN) biopsy can identify regional metastases and provides an alternative to axillary dissection that avoids arm morbidity. This investigation assessed the accuracy of SLN biopsy for predicting axillary node status. METHODS: A total of 174 clinical node-negative breast cancer patients and 165 SLN biopsies were enrolled. SLN biopsy was performed in a two-day protocol with backup axillary dissection: subdermally injected technetium-99 sulfur colloid to detect and localize SLN on day one; sentinel node harvesting under gamma-counter guidance on day two. Clinicopathological factors were statistically analyzed to assess the accuracy of the SLN biopsy. RESULTS: The SLN was identified in 94.3% (165 of 175) of cases. SLN biopsy had an accuracy of 98.2%, with sensitivity of 93.7%, specificity of 100%, negative predictive value of 97.5% and positive predictive value of 100%. Three SLN negative cases had non-SLN metastasis representing a false-negative rate of 6.3% (3 of 48). Tumor size was the only factor statistically correlated with the accuracy of the SLN biopsy. The diagnostic accuracy for tumors sized 2 cm or below was 100%. Hematoxylin-eosin stain followed by immunohistochemical stain increased the diagnosis of axillary metastasis from 25.5% to 29.1%. CONCLUSION: SLN biopsy can accurately forecast axillary node status in early breast cancer, particularly in patients with tumor sizes of no more than 2 cm.

Adult↗