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Biomedical subjects

Miho Sato

Publications and source records attributed to Miho Sato.

24 records · Page 2Linked to original sources
PubMedDate not supplied

A case of sectorial benign flecked retina.

PURPOSE: A case of sectorial benign flecked retina not associated with an RDH5 gene mutation is reported. METHODS: A 51-year-old woman showed multiple yellow-white flecks in both eyes similar to those of benign flecked retina but in only the upper half of the retina. We carried out clinical, electrophysiological, and molecular genetic examinations of the patient. RESULTS: Visual acuity was 20/20 OD and 20/20 OS. Fluorescein angiography showed diffuse irregular hypofluorescence that did not correspond to the flecked lesions. A Goldmann-Weeker adaptometer test revealed that the visual threshold of the upper retina was approximately 0.6 to 0.8 log units higher than that of the lower retina. No mutations of the RDH5 gene were detected in exons 2-5 or in the flanking intron sequences. CONCLUSIONS: To our knowledge, this is the first report of sectorial benign flecked retina, and the flecks may not be caused by an RDH5 gene mutation.

Alcohol Oxidoreductases↗
PubMedDate not supplied

Superior segmental optic hypoplasia found in Tajimi Eye Health Care Project participants.

PURPOSE: To investigate the prevalence and characteristics of superior segmental optic hypoplasia in Japanese. METHODS: We studied 14 779 subjects, aged 40 years or older, who underwent IMAGEnet fundus photography as part of a large-scale eye disease screening project conducted in Tajimi, Japan. A single researcher reviewed all of the photographs for the presence of ocular abnormality in the optic nerve head and retina, paying special attention to the presence of superior segmental optic hypoplasia. RESULTS: Fundus photographs of 14 431 cases (28,396 eyes) were successfully reviewed. We found superior segmental optic hypoplasia in 37 cases (54 eyes; 0.3% of the cases and 0.2% of the eyes). Of the 37 cases, 23 (62%) showed the corresponding visual field defect in at least one eye. CONCLUSION: The prevalence of superior segmental optic hypoplasia is about 0.3% in the Japanese population.

Adult↗
PubMedDate not supplied

Development of stereoscopic acuity: longitudinal study using a computer-based random-dot stereo test.

PURPOSE: To investigate the development of stereoscopic acuity (stereoacuity) in children longitudinally. METHODS: Seven full-term normal infants whose age at the beginning of the study was between 12 and 23 weeks were studied. A computer-based random-dot test of stereoscopic vision (TV-Random Dot Stereo Test) was used to measure stereoacuity. The test was repeated at 2- to 3-month intervals until the children reached 2 years of age, and then every 6 to 12 months until they reached 5 years of age. RESULTS: All of the infants were found to have a stereoacuity of 2480 seconds of arc (2480'') with this test by 26 weeks of age. The first reliable measurement of stereoacuity was obtained from a 16-week-old infant. Stereoacuity did not improve significantly between 6 and 12 months, but it improved rapidly after 12 months. All children had a stereoacuity of 100'' with the Titmus Stereo Tests at 5 years of age, but the best stereoacuity with the TV-Random Dot Stereo Test was 229'' at 28.9 months. CONCLUSIONS: The development of stereoacuity studied longitudinally was similar to that obtained by cross-sectional studies. The TV-Random Dot Stereo Test is a useful program for measuring stereopsis in preverbal children.

Child Development↗
PubMedDate not supplied

Interexaminer differences in the traction test of the superior oblique tendon.

PURPOSE: The traction test of the superior oblique tendon is used for the manual evaluation of the looseness or tightness of the tendon. Because of the subjective nature of this test, knowledge of other clinical findings may lead to a bias in its interpretation. We studied interexaminer differences in the results of the test to assess the reliability of this traction test. METHODS: Examiner A examined all of the patients and collected all clinical findings, including the results of magnetic resonance imaging. Each of the nine noninformed examiners participated in one or more traction tests without prior information regarding the clinical findings of the patient. The traction tests were performed on 31 patients under general anesthesia. The examiners performed the traction test alternately with examiner A and evaluated the laxity and tightness in the tendon based on a nine-step scale (-4 to +4). The results were recorded in a masked manner, and later a comparison between the evaluation results of examiner A and those of the other examiners was made. RESULTS: Examiner A and the other examiners were in agreement within one grading step on 27 of the 31 (87.1%) traction tests. CONCLUSIONS: We demonstrated that the interexaminer differences in the interpretations of the traction test were acceptable, and that after the noninformed examiners had performed the test several times, their interpretations became closer to those of examiner A.

Diagnostic Techniques, Ophthalmological↗
PubMedDate not supplied

Ultrasound biomicroscopic findings in hallerman-streiff syndrome.

PURPOSE: To demonstrate the usefulness of ultrasound biomicroscopy in detecting the morphological changes in the lens caused by the spontaneous absorption of lens material and to detect fundus abnormalities in a patient with Hallermann-Streiff syndrome. METHODS: Case report of an infant diagnosed at the age of 2 months as having Hallermann-Streiff syndrome. RESULTS: Spontaneous lens absorption occurred during the course of follow-up and was detected only by ultrasound biomicroscopy after the patient was prepared for cataract surgery. The changes in the anterior chamber depth and lens shapes were documented by ultrasound biomicroscopy. Retinal folds that were barely observable by conventional ophthalmoscopy because of a dense cataract were clearly shown by ultrasound biomicroscopy. CONCLUSIONS: Ultrasound biomicroscopy can be used to examine the lenses of eyes that are not observable with conventional optical instruments. Ultrasound biomicroscopy can also be used to study the posterior segment of microphthalmic eyes. We recommend preoperative ultrasound biomicroscopy to prevent unnecessary anesthesia and surgical preparation.

Abnormalities, Multiple↗