Biomedical subjects

Mickaël Tanter

Publications and source records attributed to Mickaël Tanter.

9 recordsLinked to original sources

PubMed2004

Supersonic shear imaging: a new technique for soft tissue elasticity mapping.

Supersonic shear imaging (SSI) is a new ultrasound-based technique for real-time visualization of soft tissue viscoelastic properties. Using ultrasonic focused beams, it is possible to remotely generate mechanical vibration sources radiating low-frequency, shear waves inside tissues. Relying on this concept, SSI proposes to create such a source and make it move at a supersonic speed. In analogy with the "sonic boom" created by a supersonic aircraft, the resulting shear waves will interfere constructively along a Mach cone, creating two intense plane shear waves. These waves propagate through the medium and are progressively distorted by tissue heterogeneities. An ultrafast scanner prototype is able to both generate this supersonic source and image (5000 frames/s) the propagation of the resulting shear waves. Using inversion algorithms, the shear elasticity of medium can be mapped quantitatively from this propagation movie. The SSI enables tissue elasticity mapping in less than 20 ms, even in strongly viscous medium like breast. Modalities such as shear compounding are implementable by tilting shear waves in different directions and improving the elasticity estimation. Results validating SSI in heterogeneous phantoms are presented. The first in vivo investigations made on healthy volunteers emphasize the potential clinical applicability of SSI for breast cancer detection.

Adult↗

PubMed2004

Assessment of elastic parameters of human skin using dynamic elastography.

Sonoelastography and transient elastography are two ultrasound-based techniques that facilitate noninvasive characterization of the viscoelastic properties of soft tissues by investigating their response to shear mechanical excitation. Young's modulus is the principle assessment parameter. Because it defines local tissue stiffness, it is of major interest for the medical imaging and cosmetic industries as it could replace subjective palpation by yielding local, quantitative information. In this paper, we describe a new high-resolution device capable of measuring local Young's modulus in very thin layers (1-5 mm) and devoted to the in vivo evaluation of the elastic properties of human skin. It uses an ultrasonic probe (50 MHz) for tracking the displacements induced by a 300 Hz shear wave generated by a ring surrounding the transducer. The displacements are measured using a conventional cross-correlation technique between successive ultrasonic back-scattered echoes. First, this noninvasive technique has been experimentally proven to be accurate for investigating elasticity in different skin-mimicking phantoms. Second, data were acquired in vivo on human forearms. As expected, Young's modulus was found to be higher in the dermis than in the hypodermis and other soft tissues.

Elasticity↗

PubMed2004

Real time inverse filter focusing through iterative time reversal.

In order to achieve an optimal focusing through heterogeneous media we need to build the inverse filter of the propagation operator. Time reversal is an easy and robust way to achieve such an inverse filter in nondissipative media. However, as soon as losses appear in the medium, time reversal is not equivalent to the inverse filter anymore. Consequently, it does not produce the optimal focusing and beam degradations may appear. In such cases, we showed in previous works that the optimal focusing can be recovered by using the so-called spatiotemporal inverse filter technique. This process requires the presence of a complete set of receivers inside the medium. It allows one to reach the optimal focusing even in extreme situations such as ultrasonic focusing through human skull or audible sound focusing in strongly reverberant rooms. But, this technique is time consuming and implied fastidious numerical calculations. In this paper we propose a new way to process this inverse filter focusing technique in real time and without any calculation. The new process is based on iterative time reversal process. Contrary to the classical inverse filter technique, this iteration does not require any computation and achieves the inverse filter in an experimental way using wave propagation instead of computational power. The convergence from time reversal to inverse filter during the iterative process is theoretically explained. Finally, the feasibility of this iterative technique is experimentally demonstrated for ultrasound applications.

Journal Article↗

PubMed2004

Revisiting iterative time reversal processing: application to detection of multiple targets.

The iterative time reversal processing represents a high speed and easy way to self-focus on the strongest scatterer in a multitarget medium. However, finding weaker scatterers is a more difficult task that can be solved by computing the eigenvalue and eigenvector decomposition of the time reversal operator, the so-called DORT method. Nevertheless, as it requires the measurement of the complete interelements response matrix and time-consuming computation, the separation of multiple targets may not be achieved in real time. In this study, a new real time technique is proposed for multitarget selective focusing that does not require the experimental acquisition of the time reversal operator. This technique achieves the operator decomposition using a particular sequence of filtered waves propagation instead of computational power. Due to its simplicity of implementation, this iterative process can be achieved in real time. This high speed selective focusing is experimentally demonstrated by detecting targets through a heterogeneous medium and in a speckle environment. A theoretical analysis compares this technique to the DORT formalism.

Journal Article↗

PubMed2003

Taking advantage of multiple scattering to communicate with time-reversal antennas.

We present an experimental demonstration showing that, contrary to first intuition, the more scattering a mesoscopic medium is, the more information can be conveyed through it. We used a multiple input-multiple output configuration: a multichannel ultrasonic time-reversal antenna is used to transmit random series of bits simultaneously to different receivers which were only a few wavelengths apart. Whereas the transmission is free of error when multiple scattering occurs in the propagation medium, the error rate is huge in a homogeneous medium.

Journal Article↗

PubMed2003

Sound focusing in rooms. II. The spatio-temporal inverse filter.

The potential of time reversal processing for room acoustics has been extensively investigated in the companion of this paper [J. Acoust. Soc. Am. 113(3), 1533-1543 (2003)]. In particular, a simple implementation of a loudspeaker time reversal antenna able to take advantage of the multiple reflections in reverberating rooms demonstrates its potential for audible range acoustics while improving focusing both in space and time. However, loss of information (e.g., sound absorption in walls or nonequalized bandwidths of the loudspeakers) during a time reversal experiment degrades the quality of time reversal focusing. In this paper, a more sophisticated technique called spatio-temporal inverse filtering is investigated that achieves time and space deconvolution of the propagation operator between the loudspeakers antenna and a set of microphones embedded inside the insonified volume. Theoretical and experimental comparisons between time reversal and inverse filter focusing are presented. Finally, advantages and limitations of both focusing approaches are highlighted.

Journal Article↗

PubMed2002

Shear modulus imaging with 2-D transient elastography.

In previous works, we have shown that time-resolved 2-D transient elastography is a promising technique for characterizing the elasticity of soft tissues. It involves the measurement of the displacements induced by the propagation of low frequency (LF) pulsed shear waves in biological tissues. In this paper, we present a novel apparatus that contains a LF vibrating device surrounding a linear array of 128 ultrasonic transducers that performs ultrafast ultrasonic imaging (up to 10,000 frames/s) and that is able to follow in real time the propagation of a LF shear wave in the human body. The vibrating device is made of two rods, fixed to electromagnetic vibrators, that produce in the ultrasonic image area a large amplitude shear wave. The geometry has been chosen both to enhance the sensitivity and to create a quasi linear shear wave front in the imaging plane. An inversion algorithm is used to recover the shear modulus map from the spatio-temporal data, and the first experimental results obtained from tissue-equivalent materials are presented.

Algorithms↗

PubMed2002

Shear elasticity probe for soft tissues with 1-D transient elastography.

Important tissue parameters such as elasticity can be deduced from the study of the propagation of low frequency shear waves. A new method for measuring the shear velocity in soft tissues is presented in this paper. Unlike conventional transient elastography, in which the ultrasonic transducer and the low frequency vibrator are two separated parts, the new method relies on a probe that associates the vibrator and the transducer, which is built on the axis of the vibrator. This setup is easy to use. The low frequency shear wave is driven by the transducer itself that acts as a piston while it is used in pulse echo mode to acquire ultrasonic lines. The results obtained with the new method are in good agreement with those obtained with the conventional one.

Algorithms↗

PubMed2002

Ultrafast compound imaging for 2-D motion vector estimation: application to transient elastography.

This paper describes a new technique for two-dimensional (2-D) imaging of the motion vector at a very high frame rate with ultrasound. Its potential is experimentally demonstrated for transient elastography. But, beyond this application, it also could be promising for color flow and reflectivity imaging. To date, only axial displacements induced in human tissues by low-frequency vibrators were measured during transient elastography. The proposed technique allows us to follow both axial and lateral displacements during the shear wave propagation and thus should improve Young's modulus image reconstruction. The process is a combination of several ideas well-known in ultrasonic imaging: ultra-fast imaging, multisynthetic aperture beamforming, 1-D speckle tracking, and compound imaging. Classical beamforming in the transmit mode is replaced here by a single plane wave insonification increasing the frame rate by at least a factor of 128. The beamforming is achieved only in the receive mode on two independent subapertures. Comparison of successive frames by a classical 1-D speckle tracking algorithm allows estimation of displacements along two different directions linked to the subapertures beams. The variance of the estimates is finally improved by tilting the emitting plane wave at each insonification, thus allowing reception of successive decorrelated speckle patterns.

Algorithms↗