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Biomedical subjects

Michael T Compton

Publications and source records attributed to Michael T Compton.

6 recordsLinked to original sources

Internet delusions.

As the use of computers, the Internet, and Internet technology becomes more pervasive in society, psychopathological thought content characterized by the incorporation of the Internet into delusions and hallucinations will become increasingly common. In the following report, three cases of psychotic inpatients are briefly presented to exemplify this trend in pathoplasticity. Interestingly, patients with no real familiarity with the Internet may just as readily incorporate such computer-associated themes into delusional thought patterns. Clinicians should be familiar with the tendency for delusional thoughts to draw from ideas important to society in general. Several interesting points about these cases include the increasing prevalence of Internet delusions, the complete unfamiliarity of two of the patients with the Internet and computers in general, and the tendency for such delusions to be of the controlling, broadcasting, and persecutory types.

Adult↗

Antipsychotic-induced hyperprolactinemia and sexual dysfunction.

This overview of antipsychotic-induced hyperprolactinemia provides a summary of the current literature in relation to conventional antipsychotic agents and the five atypical antipsychotics currently available in the United States--clozapine, risperidone, olanzapine, quetiapine, and ziprasidone. Dopaminergic antagonism within the tuberoinfundibular system causes elevation in plasma prolactin levels. Conventional antipsychotic medications and the atypical agent risperidone cause significant elevations in prolactin. Clozapine, olanzapine, quetiapine, and ziprasidone cause minimal effects on prolactin levels in adults, which may be due to a higher 5-HT2A:D2 binding ratio and differential effects on dopamine neurotransmission, with less interference in the tuberoinfundibular pathway. Antipsychotic-induced hyperprolactinemia presumably causes clinical side effects similar to those caused by other forms of hyperprolactinemia. Clinical and endocrinologic changes of hypogonadism also likely occur during chronic antipsychotic-induced hyperprolactinemia. Because hyperprolactinemia may cause clinically significant side effects in patients treated with antipsychotic medications, clinicians should be familiar with the evaluation and treatment of antipsychotic-induced hyperprolactinemia.

Animals↗