Biomedical subjects

Michael Schär

Publications and source records attributed to Michael Schär.

12 recordsLinked to original sources

PubMed2006

Monitoring and correcting spatio-temporal variations of the MR scanner's static magnetic field.

The homogeneity and stability of the static magnetic field are of paramount importance to the accuracy of MR procedures that are sensitive to phase errors and magnetic field inhomogeneity. It is shown that intense gradient utilization in clinical horizontal-bore superconducting MR scanners of three different vendors results in main magnetic fields that vary on a long time scale both spatially and temporally by amounts of order 0.8-2.5 ppm. The observed spatial changes have linear and quadratic variations that are strongest along the z direction. It is shown that the effect of such variations is of sufficient magnitude to completely obfuscate thermal phase shifts measured by proton-resonance frequency-shift MR thermometry and certainly affect accuracy. In addition, field variations cause signal loss and line-broadening in MR spectroscopy, as exemplified by a fourfold line-broadening of metabolites over the course of a 45 min human brain study. The field variations are consistent with resistive heating of the magnet structures. It is concluded that correction strategies are required to compensate for these spatial and temporal field drifts for phase-sensitive MR protocols. It is demonstrated that serial field mapping and phased difference imaging correction protocols can substantially compensate for the drift effects observed in the MR thermometry and spectroscopy experiments.

Brain↗

PubMed2006

Improved myocardial tagging contrast in cine balanced SSFP images.

PURPOSE: To improve the tag persistence throughout the whole cardiac cycle by providing a constant tag-contrast throughout all the cardiac phases when using balanced steady-state free precession (bSSFP) imaging. MATERIALS AND METHODS: The flip angles of the imaging radiofrequency pulses were optimized to compensate for the tagging contrast-to-noise ratio (Tag-CNR) fading at later cardiac phases in bSSFP imaging. Complementary spatial modulation of magnetization (CSPAMM) tagging was implemented to improve the Tag-CNR. Numerical simulations were performed to examine the behavior of the Tag-CNR with the proposed method, and to compare the resulting Tag-CNR with that obtained from the more commonly used spoiled gradient echo (SPGR) imaging. A gel phantom, as well as five healthy human volunteers, were scanned on a 1.5T scanner using bSSFP imaging with and without the proposed technique. The phantom was also scanned with SPGR imaging. RESULTS: With the proposed technique, the Tag-CNR remained almost constant during the whole cardiac cycle. Using bSSFP imaging, the Tag-CNR was about double that of SPGR. CONCLUSION: The tag persistence was significantly improved when the proposed method was applied, with better Tag-CNR during the diastolic cardiac phase. The improved Tag-CNR will support automated tagging analysis and quantification methods.

Adult↗

PubMed2006

On restoring motion-induced signal loss in single-voxel magnetic resonance spectra.

Destructive interference from phase fluctuations caused by motion during (1)H magnetic resonance spectroscopy (MRS) stimulated-echo acquisition mode (STEAM) and point-resolved spectroscopy (PRESS) acquisitions can significantly diminish the traditional radicalN-gain in signal-to-noise ratio (SNR) afforded by averaging N signals, especially in the torso. The SNR loss is highly variable among individuals, even when identical acquisition protocols are used. This paper presents a theory for the SNR loss, assuming that the phase fluctuates randomly. It is shown that SNR in conventional averaging is reduced by the factor sinc(sigma(phi) radical3/pi), where sigma(phi) is the standard deviation (SD) of the phase. "Constructive averaging," whereby each individual acquisition is phase-corrected using the phase of a high-SNR peak before averaging, reverses the SNR loss from motion-induced dephasing, resulting in a {1/sinc(sigma(phi) radical3/pi)}-fold SNR improvement. It is also shown that basing phase corrections on an average of radicalN adjacent points both improves correction accuracy and effectively eliminates false signal artifacts when corrections are based on low-SNR peaks. The theory is validated over a sevenfold range of variation in signal loss due to motion observed in (1)H STEAM and PRESS data acquired from 17 human subjects (heart: N = 16; leg: N = 1). Constructive averaging should be incorporated as a routine tool for in vivo (1)H MRS.

Artifacts↗

PubMed2006

Optimized detection of lactate at high fields using inner volume saturation.

In localized proton MR spectroscopy ((1)H-MRS) in vivo, the detection of lactate (Lac) is affected by modulation of its resonances due to homonuclear scalar couplings (J). A simple and convenient way to distinguish Lac from lipids is to set the TE to 1/J so that the Lac signal is inverted while other resonances (such as lipid) remain in-phase. However, at high field strengths, such as 3 Tesla or above, the modulation of the Lac signal is complicated by chemical shift effects that cause modulation patterns to vary within different subregions of the localized volume. Under some conditions the Lac signal may even disappear completely. In this note we introduce the concept of inner volume saturation (IVS), which makes use of high bandwidth spatial pulses to remove the signal corresponding to the regions of the localized volume that contribute unwanted modulation patterns. The method is described theoretically and demonstrated experimentally at 3 Tesla in a phantom and a patient with acute stroke. The phantom measurements indicate that virtually 100% of the Lac signal can be recovered using this method. The method should be feasible at magnetic fields above 3 Tesla, and may also be applied to other coupled spin systems in which modulation effects are important.

Aged↗

PubMed2006

MR spectroscopy and spectroscopic imaging: comparing 3.0 T versus 1.5 T.

In vivo magnetic resonance spectroscopy (MR spectroscopy) offers the unique possibility to monitor human brain metabolism in a noninvasive way. At 3.0 T, MR spectroscopy not only profits from higher available signal compared with 1.5 T, but from increased chemical shift dispersion as well. These gains may be exchanged into increased spatial resolution or speed in MR spectroscopic imaging. However, some adverse effects related to the higher field strength, such as increased field inhomogeneities and sequence restrictions caused by safety limitations need to be considered. These require protocol adaptations and technical advances that have not yet fully found their way onto the clinical platform. If neglected, effects such as chemical shift misregistration at higher field strength can lead to wrong localizations or loss of signals of certain metabolites, which can intervene with the diagnostic value of a spectrum. This article tries to give an understanding of the potentials and challenges of MR spectroscopy at the higher field strength of 3.0 T, and to give insight into new techniques that hopefully soon will become available in daily clinical routine to fully exploit all benefits of the higher field strength.

Brain↗

PubMed2005

Linear response equilibrium.

A new periodic pulse sequence employing weak excitation is presented. This type of sequence drives the system into a steady-state with periodic time evolution from which the data can be reconstructed to a spectrum. It is demonstrated that the frequency response of such a sequence can be analyzed using perturbation methods and linear system analysis. A mathematical framework is proposed allowing the frequency response to be tailored by weighting a periodic flip function. The weak excitation level used implies very low specific absorption rates while generating a highly frequency selective signal in the order of 1/T2 with signal strengths comparable to those obtainable with conventional large flip angle balanced steady-state free precession techniques. The concept is illustrated with phantom experiments and in vivo feasibility of water fat separation is shown on human knee images.

Adipose Tissue↗

PubMed2005

Synthesis of trans-1, trans-2, trans-3, and trans-4 bisadducts of C60 by regio- and stereoselective tether-directed remote functionalization.

The double Bingel reaction of fullerene C60 with bismalonates attached to a Tröger base derived tether afforded trans-1, trans-2, trans-3, and trans-4 bisadducts with excellent regioselectivity. In particular, enantiomerically pure bisadducts with inherently chiral trans-2 or trans-3 addition patterns were prepared starting from enantiomerically pure bismalonates. The absolute configuration of the trans-2 and trans-3 bisadducts was established from their CD spectra. The excellent diastereoselectivity in the double additions to give the trans-2 bisadducts is particularly remarkable given the large distance between the two reacting bonds in opposite hemispheres of the fullerene that is spanned by the tether. Now, all inherently chiral double addition patterns are readily available by tether-directed functionalization using appropriate chiral, nonracemic spacers.

Journal Article↗

PubMed2005

Anatomic considerations for the choice of surgical approach for hip resurfacing arthroplasty.

A number of surgical exposures have been advocated over the past 20 years by the pioneers of resurfacing hip arthroplasty and include the anterior, anterolateral, lateral, and posterolateral approaches. Not all of these approaches, however, appear to provide adequate exposure while respecting the local biology that seems to be imperative for the procedure. Based on an anatomic study, the most "bio-logical" surgical approach for hip resurfacing arthroplasty appears to be through a lateral or posterolateral approach using a digastric trochanteric osteotomy combined with an anterior hip dislocation. These exposures avoid injury to the medial femoral circumflex artery supplying the femoral head and allow access and treatment to the commonly observed hip pathologies that are frequently located anteriorly.

Adult↗

PubMed2004

Cardiac SSFP imaging at 3 Tesla.

Balanced steady-state free precession (SSFP) techniques provide excellent contrast between myocardium and blood at a high signal-to-noise ratio (SNR). Hence, SSFP imaging has become the method of choice for assessing cardiac function at 1.5T. The expected improvement in SNR at higher field strength prompted us to implement SSFP at 3.0T. In this work, an optimized sequence protocol for cardiac SSFP imaging at 3.0T is derived, taking into account several partly adverse effects at higher field, such as increased field inhomogeneities, longer T(1), and power deposition limitations. SSFP contrast is established by optimizing the maximum amplitude of the radiofrequency (RF) field strength for shortest TR, as well as by localized linear or second-order shimming and local optimization of the resonance frequency. Given the increased SNR, sensitivity encoding (SENSE) can be employed to shorten breath-hold times. Short-axis, long-axis, and four-chamber cine views obtained in healthy adult subjects are presented, and three different types of artifacts are discussed along with potential methods for reducing them.

Adult↗

PubMed2004

Navigator gating and volume tracking for double-triggered cardiac proton spectroscopy at 3 Tesla.

Respiratory motion compensation based on navigator echoes for double-triggered cardiac proton spectroscopy at 3.0 T is presented. The navigators measure the displacement of the liver-lung interface during free breathing. This information allows for double triggering on a defined window within the respiratory cycle and on a defined trigger delay after the R-wave based on the ECG. Furthermore, it allows the excitation volume to be shifted by the determined respiratory displacement within the defined window in real-time (volume tracking). Static and motion phantom experiments were performed in this study, and it was demonstrated that volume tracking permits the suppression of signal from tissue next to the localized volume. However, triggering on a defined respiratory position is still necessary to achieve high spectral quality, because shimming and water suppression calibration are only optimal for a small window of the respiratory cycle. Single-volume spectra obtained in the myocardial septum of healthy subjects are presented.

Electrocardiography↗

PubMed2003

The impact of spatial resolution and respiratory motion on MR imaging of atherosclerotic plaque.

PURPOSE: To examine the impact of spatial resolution and respiratory motion on the ability to accurately measure atherosclerotic plaque burden and to visually identify atherosclerotic plaque composition. MATERIALS AND METHODS: Numerical simulations of the Bloch equations and vessel wall phantom studies were performed for different spatial resolutions by incrementally increasing the field of view. In addition, respiratory motion was simulated based on a measured physiologic breathing pattern. RESULTS: While a spatial resolution of > or = 6 pixels across the wall does not result in significant errors, a resolution of < or = 4 pixels across the wall leads to an overestimation of > 20%. Using a double-inversion T2-weighted turbo spin echo sequence, a resolution of 1 pixel across equally thick tissue layers (fibrous cap, lipid, smooth muscle) and a respiratory motion correction precision (gating window) of three times the thickness of the tissue layer allow for characterization of the different coronary wall components. CONCLUSIONS: We found that measurements in low-resolution black blood images tend to overestimate vessel wall area and underestimate lumen area.

Arteriosclerosis↗

PubMed2002

Volume tracking cardiac 31P spectroscopy.

The limited reliability and accuracy of cardiac spectroscopy have been partly attributed to effects from respiratory motion. In this work, we developed a prospective volume tracking method for respiratory motion compensation based on multiple navigator echoes and demonstrated its application in cardiac (31)P spectroscopy. The sequence consists of two 2D selective excitation pulses preceding the spectroscopic experiment to sample respiratory motion components. The navigator information is evaluated in real-time to calculate the shift of the heart from respiration. Based on the displacement information, the spectroscopic volume and/or grid position is prospectively corrected to track the volume of interest. The method was validated with a moving compartment phantom simulating in vivo respiratory motion. With volume tracking, no signal contamination was apparent. Spectra obtained in 14 healthy volunteers were evaluated using time-domain fitting procedures. The fitting accuracy improved consistently with volume tracking compared to data from non-navigated reference acquisitions. Compared to other gating approaches available for spectroscopy, the current technique does not degrade the scan efficiency, thus allowing effective use of scan time.

Adenosine Triphosphate↗