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Biomedical subjects

Michael Esterman

Publications and source records attributed to Michael Esterman.

4 recordsLinked to original sources

Categorization influences illusory conjunctions.

Illusory conjunctions (ICs) provide evidence for a binding problem that must be resolved in vision. Objects that are perceptually grouped are more likely to have their features erroneously conjoined. We examined whether semantic grouping, determined by category membership (letter vs. number), also influences illusory conjunction rates. Participants were instructed to detect an "L" or a "7" among briefly presented character strings and to report its color. Despite high shape discrimination accuracy, participants often made color conjunction errors, reporting instead the color of a distractor character, "O". This distractor could be ambiguously interpreted as a letter or a number. The status of the "O" was determined by other noncolored flanker characters, which were either letters or numbers. When both the target and flankers were of the same category, participants made more ICs than when the target and flankers were of different categories. This finding demonstrates that alphanumeric categorization can precede and subsequently influence binding.

Adult↗

The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.

The gastrointestinal peptide hormone ghrelin stimulates appetite in rodents and humans via hypothalamic actions. We discovered expression of ghrelin in a previously uncharacterized group of neurons adjacent to the third ventricle between the dorsal, ventral, paraventricular, and arcuate hypothalamic nuclei. These neurons send efferents onto key hypothalamic circuits, including those producing neuropeptide Y (NPY), Agouti-related protein (AGRP), proopiomelanocortin (POMC) products, and corticotropin-releasing hormone (CRH). Within the hypothalamus, ghrelin bound mostly on presynaptic terminals of NPY neurons. Using electrophysiological recordings, we found that ghrelin stimulated the activity of arcuate NPY neurons and mimicked the effect of NPY in the paraventricular nucleus of the hypothalamus (PVH). We propose that at these sites, release of ghrelin may stimulate the release of orexigenic peptides and neurotransmitters, thus representing a novel regulatory circuit controlling energy homeostasis.

Agouti-Related Protein↗

Aware and unaware perception in hemispatial neglect: evidence from a stem completion priming task.

The current study used the process dissociation procedure in conjunction with a stem-completion priming task to disentangle the influences of aware and unaware perception in patients with hemispatial neglect. One lateralized picture prime was presented simultaneously with a filler picture followed by a centrally presented word stem. In the inclusion condition participants were asked to complete the word stem with the previously presented picture name; in the exclusion task they were asked to complete the stem with the name of a picture other than the one previously presented. Findings indicated that neglect patients had reduced unaware perception of pictures presented in the left visual field and an absence of awareness for those same pictures. In addition, patients had reduced awareness for right visual field pictures, but unaware perception remained intact. These findings suggest that observations of preserved information processing in neglect are due to residual unaware perception and not due to residual awareness of information in the neglected hemispace.

Aged↗

Triangular backgrounds shift line bisection performance in hemispatial neglect: the critical point.

Isosceles triangular backgrounds influence line bisection performance in normal control participants and patients with hemispatial neglect. When the triangles are oriented asymmetrically with the vertex in I visual field, and the base in the other, the perceived midpoint of horizontal lines within the triangle is shifted towards the base, and away from the vertex. The current study examines this illusion further by systematically varying the extent of the triangle presented. With only fragments of the triangle in the background of the line, the vertex is the critical component driving the illusory shift in perceived midpoint. Patients with neglect and controls are equally sensitive to the illusion. Similar geometric illusions that are also intact in neglect, along with these results, suggest that preattentive, implicit visual processing is preserved in neglect and drives these illusions.

Aged↗