Biomedical subjects

Mehmet Arslan

Publications and source records attributed to Mehmet Arslan.

21 records · Page 2Linked to original sources

PubMedDate not supplied

Carcinoma erysipelatoides resulting from gastric adenocarcinoma: an unusual clinical presentation.

OBJECTIVE: To report a rare case of carcinoma erysipelatoides on the laryngeal skin caused by stomach adenocarcinoma. CLINICAL PRESENTATION AND INTERVENTION: A 48-year-old male, who had undergone a gastrectomy 18 months prior to admission for stage IIIA gastric adenocarcinoma, presented with a reddish induration of the cervical skin, lymphadenopathy in both supraclavicular areas and widespread subcutaneous nodules. Abdominal computerized tomography and chest radiography did not reveal any organ metastasis or peritoneal carcinomatosis. A biopsy of the induration revealed atypical epithelial cells with edema and dilatation of lymphatics. The patient was given combination chemotherapy of etoposide, adriamycin, and cisplatin, and significant improvement was observed over the cervical area after three courses. The patient tolerated the systemic chemotherapy well and has been followed for two months. CONCLUSION: We recommend combination chemotherapy in patients with cutaneous metastasis of gastric adenocarcinoma as a safe and effective treatment.

Adenocarcinoma↗

PubMedDate not supplied

Early medical treatment is life saving in acute Budd-Chiari due to polycythemia vera.

Here we describe two women with polycythemia vera presented with fulminant hepatic failure due to acute Budd-Chiari syndrome. Both had a history of severe abdominal pain and distention of short duration. Clinical and laboratory findings showed fulminant hepatic failure due to acute Budd-Chiari syndrome. Diagnosis was confirmed with abdominal ultrasonography and Doppler ultrasonography showing ascites, hepatomegaly, portal hypertension and total occlusion of hepatic veins. Complete blood count and other clinical findings were compatible with polycythemia vera in both patients. Patients were treated successfully with early administration of continuous heparin infusion, repeated phlebotomies and hydroxyurea. We emphasize here early diagnosis and effective treatment in such fulminant cases may be life saving.

Acute Disease↗

PubMedDate not supplied

Portal vein thrombosis in cirrhotics: related with anticardiolipin antibodies?

BACKGROUND/AIMS: To evaluate the relationship of antiphospholipid antibodies and portal vein thrombosis in cirrhotics. METHODOLOGY: 22 cirrhotics without portal vein thrombosis (Group I), 18 with portal vein thrombosis (Group II) and 20 healthy controls (Group III) were enrolled. Anticardiolipin IgG and IgM antibody concentrations were measured by ELISA and lupus anticoagulant by clotting. Groups were compared according to sex, age, etiology of cirrhosis, prior intraabdominal surgery, Child groups, anticardiolipin IgG, IgM and lupus anticoagulant. Then for all the 40 cirrhotics (Group IV) correlation was tested between anticardiolipin IgM, IgG, lupus anticoagulant and Child groups, etiology of cirrhosis, sex and prior surgery. RESULTS: In Group I, anticardiolipin IgG concentration was 15.3 (15.9) GPL)/mL and IgM was 8.6 (6.5) MPL/mL. In 6 (27.27%) anticardiolipin IgG, in 6 (27.27%) IgM and in 2 (9.09%) both were high. Lupus anticoagulant was positive in 7 (31.81%). In Group II anticardiolipin IgG concentration was 26.3 (14.7) GPL/mL and IgM was 15.1 (7.2) MPL/mL. In 10 (55.55%) anticardiolipin IgG, in 13 (72.22%) IgM and in 9 (50%) both were high. Lupus anticoagulant was positive in 5 (27.77%). In Group III lupus anticoagulant was positive in 1 (0.5%). Anticardiolipin IgG was 10.3 (5.9) GPL/mL, IgM 5 (3.6) MPL/mL anticardiolipin IgM level was high in 1 (0.5%). Group I and II were similar with respect to lupus anticoagulant, Child groups, prior intraabdominal surgery and etiology of cirrhosis. For anticardiolipin IgG and IgM there was a significant difference between Group I and II, I and III and II and III. In Group IV there was no correlation between prior abdominal surgery, Child groups, sex, etiology and anticardiolipin IgG, IgM or lupus anticoagulant. CONCLUSIONS: Anticardiolipin antibody concentrations were significantly higher in cirrhotics with portal vein thrombosis. Thus anticardiolipin antibodies may play a role in the development of portal vein thrombosis in cirrhosis.

Antibodies, Anticardiolipin↗