Biomedical subjects

Matthew J Dejneka

Publications and source records attributed to Matthew J Dejneka.

3 recordsLinked to original sources

PubMed2004

Tm3+ cladding-doped fiber for selective wavelength filtering in high-power pump lasers.

Scattering and reflection of transmission band power in a fiber amplifier cause increased bit-error rates through multiple path interference (MPI). We report a passive method for reducing MPI contributions from the front facet of a 980-nm fiber-Bragg-grating-stabilized pump laser by use of a Tm3+-doped fiber pigtail between the diode facet and the fiber Bragg grating. Optical return loss in the C band is reduced to below -30 dB.

Journal Article↗

PubMed2003

Microbarcode sorting device.

A novel and simple microfluidic device was developed for sorting 20 microm thick glass microbarcodes for imaging or scanning at the completion of a bead-based assay. Specifically, the microbarcodes are dried and kept from stacking on top of one another such that a monolayer of microbarcodes is created and the microbarcodes lay flat on a surface. The microbarcode sorting device consists of a reservoir, a sorting region, and a network of microchannels. With minimal microbarcodes loss, a monolayer of microbarcodes is created and trapped inside the sorting region for conveniently imaging or scanning. The device can also be used for any geometrical shaped beads with a range of thicknesses and can be adapted to a 96-well plate format for high throughput analysis.

Animals↗

PubMed2003

Rare earth-doped glass microbarcodes.

The development of ultraminiaturized identification tags has applications in fields ranging from advanced biotechnology to security. This paper describes micrometer-sized glass barcodes containing a pattern of different fluorescent materials that are easily identified by using a UV lamp and an optical microscope. A model DNA hybridization assay using these "microbarcodes" is described. Rare earth-doped glasses were chosen because of their narrow emission bands, high quantum efficiencies, noninterference with common fluorescent labels, and inertness to most organic and aqueous solvents. These properties and the large number (>1 million) of possible combinations of these microbarcodes make them attractive for use in multiplexed bioassays and general encoding.

Biotechnology↗