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Biomedical subjects

Mats Carlsson

Publications and source records attributed to Mats Carlsson.

2 recordsLinked to original sources

High-frequency acoustic waves are not sufficient to heat the solar chromosphere.

One of the main unanswered questions in solar physics is why the Sun's outer atmosphere is hotter than its surface. Theory predicts abundant production of high-frequency (10-50 mHz) acoustic waves in subsurface layers of the Sun, and such waves are believed by many to constitute the dominant heating mechanism of the chromosphere (the lower part of the outer solar atmosphere) in non-magnetic regions. Such high-frequency waves are difficult to detect because of high-frequency disturbances in Earth's atmosphere (seeing) and other factors. Here we report the detection of high-frequency waves, and we use numerical simulations to show that the acoustic energy flux of these waves is too low, by a factor of at least ten, to balance the radiative losses in the solar chromosphere. Acoustic waves therefore cannot constitute the dominant heating mechanism of the solar chromosphere.

Journal Article↗

Global gene expression analysis by combinatorial optimization.

Generally, there is a trade-off between methods of gene expression analysis that are precise but labor-intensive, e.g. RT-PCR, and methods that scale up to global coverage but are not quite as quantitative, e.g. microarrays. In the present paper, we show how how a known method of gene expression profiling (K. Kato, Nucleic Acids Res. 23, 3685-3690 (1995)), which relies on a fairly small number of steps, can be turned into a global gene expression measurement by advanced data post-processing, with potentially little loss of accuracy. Post-processing here entails solving an ancillary combinatorial optimization problem. Validation is performed on in silico experiments generated from the FANTOM data base of full-length mouse cDNA. We present two variants of the method. One uses state-of-the-art commercial software for solving problems of this kind, the other a code developed by us specifically for this purpose, released in the public domain under GPL license.

Algorithms↗