Biomedical subjects

Masato Asahina

Publications and source records attributed to Masato Asahina.

22 records · Page 2Linked to original sources

PubMed2003

Cutaneous sympathetic function in patients with multiple system atrophy.

Some procedures increase the sweat output (SSwR; sympathetic sweat response) and reduce the cutaneous blood flow (SVR; skin vasomotor reflex) in the hand. We evaluated SSwRs and SVRs to deep inspiration, mental arithmetic, exercise, and tactile stimulation in 40 MSA patients and 15 healthy controls. We also conducted head-up tilt tests and R-R interval variation tests (CV(R-R)). SSwRs were present in all controls, but absent in 19 (47.5 %) of the MSA patients. The mean SSwR amplitudes in the MSA group were significantly lower than those in the control group. SVRs were evoked in all subjects except 3 MSA patients. There were no marked differences in SVR amplitudes between the two groups. Orthostatic hypotension and low CV(R-R) values were seen in 18 (45 %) and 13 (32.5 %) of the MSA patients, respectively. SSwR amplitudes correlated significantly with postural fall in blood pressure and CV(R-R) values in the MSA group. SSwRs were absent in about half of the MSA patients, and the SSwR results correlated with those of the cardiovascular autonomic tests. The SVRs were not severely disturbed in the MSA patients. We considered SSwR a useful index for the detection of autonomic dysfunction in MSA.

Blood Flow Velocity↗

PubMed2003

Emotional sweating response in a patient with bilateral amygdala damage.

Sweat output on the palm or sole is distinct from thermoregulatory sweating and has been designated emotional sweating. The amygdala has been implicated in this phenomenon, but the role it plays remains unclear. We had the chance to evaluate emotional sweating in a 21-year-old female with bilateral restricted amygdala lesions caused by idiopathic subacute limbic encephalitis. At the peak of the illness, sweat responses in the palm were not evoked in this patient in conjunction with any sympathetic activation procedures, including deep inspiration, mental arithmetic, isotonic exercise, and tactile stimulation. After neurological improvement associated with diminution of amygdala lesions on the magnetic resonance imaging, normal sweat responses were incited. This indicates that the amygdala does play an important role in emotional sweating.

Adult↗

PubMed2003

Cutaneous sympathetic function and cardiovascular function in patients with progressive supranuclear palsy and Parkinson's disease.

Some procedures, such as deep inspiration, increase sweat output (SSwR; sympathetic sweat response) and reduce cutaneous blood flow (SVR; skin vasomotor reflex) on the palm. We investigated SSwR, SVR, and cardiovascular function in 12 patients with progressive supranuclear palsy (PSP), 13 patients with Parkinson's disease (PD), and 9 healthy subjects. In the PSP patients, SSwR was severely diminished, whereas SVR was maintained and cardiovascular function was well preserved. In the PD patients, SSwR was relatively preserved, SVR was maintained, and some patients showed cardiovascular hypofunction. A combination of skin sympathetic and cardiovascular tests may be useful for distinguishing between PD and PSP.

Aged↗

PubMed2003

Laryngeal stridor in multiple system atrophy.

The purpose of this study was to elucidate the clinical features of laryngeal stridor in 104 patients with multiple system atrophy (MSA) and to predict the hazard risk. Stridor was observed in 36 patients. It occurred in the first year of the disease in 10 cases, and 69% of the cases were diagnosed with stridor within the first 4 years. Dysphagia and hoarseness had a statistically higher frequency in the stridor group, and the onset period of these elements correlated with the onset of stridor. A follow-up study of survival probability was carried out in 83 patients. The median survival period in the stridor group (33 cases) and the non-stridor group (50 cases) was 8.0 and 9.0 years, respectively. Treatment for stridor decreased the relative risk from 2.998 to 0.147. Laryngeal stridor is a common and early clinical symptom in MSA. Early treatment for stridor is advisable to reduce mortality.

Adult↗