Biomedical subjects

Masaru Suzuki

Publications and source records attributed to Masaru Suzuki.

22 records · Page 2Linked to original sources

PubMed2002

Correlation between QT dispersion and burn severity.

QT dispersion, defined as the maximal-minus-minimal QT interval on a 12-lead electrocardiogram, has emerged as a non-invasive measurement for quantifying the spatial inhomogeneity of ventricular repolarization under various conditions, including acute stress. Because burn injuries elicit acute stress reactions, it was hypothesized that QT dispersion increases with the severity of the burn injury. To test the hypothesis, 13 burned patients (age range of 22-76 years, nine males, ranging from 4.0 to 75.0% of total body surface area burned) in whom a measurable 12-lead electrocardiogram had been obtained within 4h after arrival at the emergency department were identified retrospectively, and their QTc intervals, i.e. QT intervals corrected for heart rate by the standard Bazett formula, were measured. QTc dispersion (QTcd) was then calculated, and correlations were assessed with burn severity (burn index, BI; prognostic burn index, PBI). Of the 13 patients, nine patients had a prolonged QTcd (>40 ms), and linear correlation analyses showed significant positive correlations between QTcd and both BI and PBI (r=0.61 and 0.62, respectively). In conclusion, QT dispersion was greater in the burned patients, and although the pathophysiology was unclear from the present study, the findings suggested that acute stress contributed to the spatial inhomogeneity of ventricular repolarization.

Adult↗

PubMed2002

IFN-gamma secretion by CD8T cells inhibits allergen-induced airway eosinophilia but not late airway responses.

BACKGROUND: CD8+T cells can suppress allergen-induced late airway responses (LARs) and airway inflammation. OBJECTIVE: To test the hypothesis that the suppression of LARs and airway eosinophilia by CD8+T cells is IFN-gamma mediated, we tested the effects of adoptively transferred CD8+T cells, in which IFN-gamma synthesis was inhibited by an antisense (AS) oligodeoxynucleotide (ODN), on the airway responses of a rat model of allergic asthma. METHODS: CD8+T cells were harvested from the cervical lymph nodes of ovalbumin (OVA)-sensitized Brown Norway rats for administration to other actively sensitized syngeneic rats. CD8+T cells (2 x 10(6)) were incubated for 6 hours with 2 micromol/L AS ODN or sense ODN and were injected intraperitoneally into recipients; inhibition of IFN-gamma expression in vitro by AS ODN was shown by means of flow cytometry. Two days later, rats were challenged with aerosolized OVA. RESULTS: OVA-induced LAR and bronchoalveolar lavage (BAL) fluid eosinophilia were suppressed by sense ODN-treated CD8+T cells. IFN-gamma expression in BAL cells was elevated in these animals. IFN-gamma expression in BAL cells was at control levels in recipients of AS ODN-treated CD8+ cells, confirming the success of the AS treatment in vivo. BAL eosinophilia was also largely restored in the AS ODN treatment group. In contrast, the CD8+T cell-induced suppression of the LAR was not significantly affected by AS ODN pretreatment. CONCLUSIONS: These results indicate that CD8+T cells inhibit airway eosinophilia through secretion of IFN-gamma but may suppress the LAR by means of other mechanisms.

Adoptive Transfer↗

PubMed2002

Characteristics of elderly patients presenting to the emergency department with injury.

BACKGROUND: In Japan, emergency departments (ED) receive a large proportion of elderly patients each year. As such, injuries in the elderly are a common reason for presentation to the ED. Knowledge about the characteristics of injuries presenting to the ED would be invaluable in devising strategies to prevent injury in the elderly. OBJECTIVE: To analyze the characteristics of injuries in the elderly presenting to the ED and compare them with those of the younger population. SETTING: The ED at Keio University Hospital, a large inner city teaching hospital located in Tokyo. METHOD: A retrospective analysis of data extracted from the ED database of the Keio University Hospital. Information regarding patients aged 65 years or above presenting with injury was analyzed and compared with those aged less than 65 years. Prehospital triage by emergency personnel was adopted as the severity of patients, namely "life-threatening" or "non life-threatening". RESULTS: 20% of all ED presentations of elderly patients were injury related compared to 39% of non-elderly. Compared to the non-elderly, elderly patients presenting to the ED with injury were more likely to be female, sustained injury from trauma unrelated to motor vehicle accidents (MVA) and requiring hospital admission as a result of "non life-threatening" injuries. They were less likely to have injuries from MVA or burns. The number of "life-threatening" injury cases and mortality in both groups were similar. There was evidence that the number of ED presentations relating to injury is increasing in the elderly population. CONCLUSION: Elderly injury patients are a distinct group with distinctive demographics, mechanism of injury and outcomes. This information would be useful in the planning of injury prevention programs, with particular emphasis on elderly females and MVA-unrelated trauma.

Adult↗

PubMed2002

[Breast sarcoidosis].

Sarcoidosis is a multisystem disorder of unknown etiology characterized histologically by the presence of noncaseating epithelioid cell granuloma. Extrapulmonary organs most commonly affected are the lymph nodes and the skin. Sarcoid involvement of the breast is extremely rare but when present it may be confused with a malignant neoplasm clinically. A review of literature disclosed 29 cases of breast sarcoidosis. In seventeen cases(61%) a breast tumor was first manifestation of systemic sarcoidosis. Three cases were co-exist with breast cancer. All but one cases were required excisional biopsy. We discuss some diagnostic problems such as sarcoid-like reaction briefly.

Biopsy↗