Biomedical subjects

Masahiro Iida

Publications and source records attributed to Masahiro Iida.

6 recordsLinked to original sources

PubMed2005

[Promoter hypermethylation of tumor-associated genes in head and neck cancer].

An important pathway of gene transcriptional inactivation is hypermethylation at the CpG islands of promoter regions. Some tumor suppressor genes have been reported to harbor promoter hypermethylation in head and neck cancer. We studied DNA hypermethylation of 4 genes in 42 cases of primary head and neck cancer. We applied methylation specific PCR for p16, RAR-beta, RASSF1A, and Fhit genes. Hypermethylation was detected at p16 in 43%, at RAR-beta in 40%, at RASSF1A in 12%, and at Fhit in none of the cases. Hypermethylation of at least one gene was detected in 26 (62%) of the 42 cases. No significant correlation was seen between methylation status and clinicopathological findings or prognosis. Hypermethylation of several tumor-associated genes plays an important role in tumorigenesis of head and neck cancer. We discuss clinical implications and their application.

Acid Anhydride Hydrolases↗

PubMed2004

[Bulbovascular compression by megadolichobasilar artery manifested as neurogenic and refractory hypertension].

A 37-year-old man with juvenile and refractory hypertension was admitted to our hospital for progressive left hearing loss, vertigo, and dizziness. Neurological examination revealed left hearing loss and exaggerated deep tendon reflexes and vestibular dysfunction. MRI and cerebral angiography disclosed megadolichobasilar artery (MDBA). Moreover, modified MR cisternography at the medulla disclosed marked compression and deformity of the left rostral ventrolateral medulla (RVLM) by the dolichoectatic right vertebral artery. In the literatures, bulbovascular compression has been reported in 4 among 9 patients with MDBA (including the present patient), for whom MRI of the medulla was presented. All 4 patients suffered from hypertension, and at least 3 of them showed juvenile and refractory hypertension. Ipsilateral pyramidal tract disturbance (Opalski syndrome) was observed in 3 patients. Considering the recent concept that the cardiovascular center can be localized at the RVLM, juvenile and refractory hypertension, and possibly Opalski syndrome in the present patient can be attributed to bulbovascular compression by MDBA. In the patients with MDBA and hypertension or Opalski syndrome, MR cisternography of the medulla is warranted to evaluate compression by MDBA.

Adult↗

PubMed2004

Airway management during the laryngoscopic surgery for the benign laryngeal obstructive disease.

The airway management and anesthesia maintenance during the laryngoscopic surgery is essential for a safe operation. For the benign laryngeal obstructive disease such as a large mass or a foreign body of the upper airway, it is difficult to secure the airway. Sometimes they might be hazardous and potentially lethal. We present two cases of a large laryngeal polyp and a laryngeal foreign body of pressthrough-package (PTP). They were successfully operated on with laryngomicrosurgery under neuroleptanalgesia (NLA) without intubation. The choice of the operation and airway management were discussed.

Airway Obstruction↗

PubMed2004

A case of accessory parotid gland tumor.

We herein describe a case of accessory parotid gland tumor, including diagnosis and surgical approach. The accessory parotid gland is salivary tissue separated from the main parotid gland and lying on masseter muscle. It has secondary duct empting into the Stensen's duct. The accessory parotid gland exists in 21-61 % of individuals. However, the appearance of an accessory parotid tumor is rare, with a reported frequency of 1-7.7 % of all parotid gland tumors. Surgical resection is the treatment of choice for the accessory parotid gland tumor. It is important to identify the buccal branch of the facial nerve to avoid injury to the facial nerve. The tumor in our case was surgically resected without facial nerve injury. The histopathological diagnosis was pleomorphic adenoma.

Adenoma, Pleomorphic↗

PubMed2003

[Impact of the "Doctor-Heli" system for emergency and critical care medicine in otolaryngology].

We reported the "Doctor-Heli" (medical service helicopter) system at the center of emergency and critical care medicine at Tokai University Hospital. From October 1999 to March 2001, the service had transported 485 patients, shortening the time to critical care and improving patient-prognosis. We report a case of cervical and laryngeal trauma occurring during a suicide attempt successfully treated thanks to the rapid start of critical care enabled by use of the helicopter. The service has proven its utility in otolaryngology and head and neck surgery.

Air Ambulances↗

PubMed2002

Spatial reference and standing posture during high-speed Coriolis stimulation.

BACKGROUND: In a previous study, we found that sensation, gaze, and posture during Coriolis stimulation differ considerably between vision and nonvision conditions during rotations at 60 degrees x s(-1). To determine the validity of these findings at higher velocities, we compared standing postures during Coriolis stimulation up to 150 degrees x s(-1) between vision and nonvision conditions. METHODS: The 19 subjects underwent 5-min rotation tests at 50 to 150 degrees x s(-1). While standing on a force platform attached to a rotating device, each subject tilted his or her head and then returned it to upright, first with the eyes covered, then with eyes open. Six subjects were re-examined 5 d later after 4 consecutive days of 20-min rotations with their eyes open. We assessed success and failure to stand and recorded the center of pressure during rotation. RESULTS: Although success rates (number of successes/19) differed between vision and nonvision conditions at 50 degrees x s(-1) (94.7% vs. 57.9%), they steeply decreased as rotation velocity increased and showed no difference at 70 degrees x s(-1) and faster velocities. After the 4-d exposure, however, subjects could stand at higher velocities particularly under the vision condition. A patient with bilateral labyrinthine loss, being examined for reference, could stand at 110 degrees x s(-1) even with the eyes covered. CONCLUSIONS: Untrained subjects frequently fell during high-speed Coriolis stimulation, apparently because vision was insufficient to provide a spatial reference frame from the stationary surroundings. Following rotation training with their eyes open, subjects appeared more able to use the visual reference frame and falls were reduced.

Adult↗