Virtual colonoscopy.
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Biomedical subjects
Publications and source records attributed to Martina Morrin.
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A recently developed parallel magnetic resonance (MR) imaging technique, parallel imaging with an augmented radius in k space, was used to accelerate the volumetric interpolated breath-hold examination (VIBE) performed in 20 patients referred for clinical liver imaging. Nonaccelerated MR images were also acquired in these patients. A five-point scale was used to score the quality of the images. The acceleration resulted in reduced image quality: The nonaccelerated images had a significantly higher (P <.05) mean score--3.8 +/- 0.3 (SD), indicating good quality--than the accelerated images--3.0 +/- 0.3, indicating acceptable quality. However, for three patients who could not hold their breath for the duration necessary for nonaccelerated imaging, less severe breathing artifacts on the accelerated images resulted in improved quality compared with the quality of the nonaccelerated images. Parallel MR imaging-accelerated VIBE may be beneficial for patients who have difficulty sustaining a breath hold for the duration necessary to perform nonaccelerated imaging.
BACKGROUND & AIMS: No multicenter study has been reported evaluating the performance and interobserver variability of computerized tomographic colonography. The aim of this study was to assess the accuracy of computerized tomographic colonography for detecting clinically important colorectal neoplasia (polyps >or=10 mm in diameter) in a multi-institutional study. METHODS: A retrospective study was developed from 341 patients who had computerized tomographic colonography and colonoscopy among 8 medical centers. Colonoscopy and pathology reports provided the standard. A random sample of 117 patients, stratified by criterion standard, was requested. Ninety-three patients were included (47% with polyps >or=10 mm; mean age, 62 years; 56% men; 84% white; 40% reported colorectal symptoms; 74% at increased risk for colorectal cancer). Eighteen radiologists blinded to the criterion standard interpreted computerized tomography colonography examinations, each using 2 of 3 different software display platforms. RESULTS: The average area under the receiver operating characteristic curve for identifying patients with at least 1 lesion >or=10 mm was 0.80 (95% lower confidence bound, 0.74). The average sensitivity and specificity were 75% (95% lower confidence bound, 68%) and 73% (95% lower confidence bound, 66%), respectively. Per-polyp sensitivity was 75%. A trend was observed for better performance with more observer experience. There was no difference in performance across software display platforms. CONCLUSIONS: Computerized tomographic colonography performance compared favorably with reported performance of fecal occult blood testing, flexible sigmoidoscopy, and barium enema. A prospective study evaluating the performance of computerized tomography colonography in a screening population is indicated.