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Biomedical subjects

Martin Voracek

Publications and source records attributed to Martin Voracek.

At least 37 records · Page 2Linked to original sources
PubMed2006

Ancestry, genes, and suicide: a test of the Finno-Ugrian Suicide Hypothesis in the United States.

There is now convergent evidence from classic quantitative genetics (family, twin, and adoption studies) and molecular genetic studies for specific genetic risk factors for suicidal behavior. This emerging research field has recently been supplemented by geographical studies concerned with the Finno-Ugrian Suicide Hypothesis (FUSH), which states that population differences in genetic risk factors may partially account for conspicuous geographical patterns seen in suicide prevalence. In particular, the European high-suicide-rate nations constitute a contiguous, J-shaped belt, spanning from Finland to Austria. This area maps onto the second principal component identified for European gene distribution, most likely reflecting a major migration event of the past (i.e., the ancestral adaptation to cold climates and the Uralic language dispersion) still detectable in modern European populations. The present research tested the hypothesis in the United States. Consistent with the hypothesis, available historical (1913-1924 and 1928-1932) U.S. state suicide rates were uniformly positively associated with available state proportions of reported American ancestries from European high-suicide-rate countries (Hungary, Lithuania, Poland, Russia, Slovakia, and the Ukraine). However, contrary to the hypothesis, available contemporary (1990-1994) suicide rates were uniformly negatively associated with these ancestry proportions. The findings of this first test outside Europe are therefore conflicting. A proposal based on the geographical study approach is offered to further the progress of investigations into the genetics of suicide.

Cause of Death↗
PubMed2006

Regional intelligence and suicide rate in Germany.

Regional intelligence proxies (intranational average domain scores from the PISA 2000 and 2003 studies) were not reliably associated with the suicide rate across the states of Germany, thereby not replicating findings of a positive ecological correlation of regional intelligence and suicide prevalence from other within-nation studies (Austria, Belarus, the British Isles, Denmark, The Netherlands, and the USA).

Cross-Sectional Studies↗
PubMed2006

Educational attainment, intelligence, interstate migration, and suicide rates in the United States: rejoinder to Abel and Kruger (2005).

Abel and Kruger (2005) reported a negative association of educational attainment and suicide rate across the United States. Given strong links between intelligence and educational attainment, this appears to be inconsistent with positive associations of intelligence and suicide rate reported in several other geographical studies. However, the apparent inconsistencies may reflect interstate migration within the U.S. adult population. Testing this hypothesis showed that interstate migration was more strongly related to state suicide rates than educational attainment. Thus, the different results obtained by Abel and Kruger could reflect migration effects, which for the U.S. might render adult-age indicators of educational attainment inappropriate to reflect regional variation in intelligence by place of birth.

Achievement↗
PubMed2006

Regional intelligence and suicide rate in Denmark.

Consistent with evidence from several recent geographical (cross-national and within-nation) studies (by Lester and by Voracek), a positive ecological (aggregate-level) correlation of regional intelligence and suicide rate was found across the seven major geographical regions of Denmark.

Denmark↗
PubMed2006

Medical and psychology students' disbelief in the inheritance of risk factors for suicide.

Despite convergent evidence for a role of genetic risk factors for suicide stemming from quantitative genetic (family, twin, and adoption designs), molecular genetic, and geographical studies, professionals, likely to be exposed to suicide, appear to disbelieve strongly in the inheritance of risk factors for suicide. In a sample of 1,093 Austrian medical and psychology students, about 80% of respondents did not endorse genetic risk factors for suicide, regardless of their sex, age bracket, field and year of study, and overall knowledge on suicide facts. This may reflect educational gaps, cognitive biases against genetic bases and explanations, or both. One single implication is that this information needs to be incorporated and covered more visibly in medical and psychology textbooks and curricula.

Adult↗
PubMed2005

2nd to 4th digit ratio (2D:4D) and number of sex partners: evidence for effects of prenatal testosterone in men.

The number of sexual partners per individual (NSP) is an important component of sexual behaviour. Here, we report two studies concerning the relationship between a probable negative correlate of prenatal testosterone, the ratio of the length of 2nd and 4th digits (2D:4D), and NSP in men. The right hand 2D:4D ratio appears to be more strongly related to prenatal testosterone than does the left hand. Accordingly we found: (a) in a sample of 99 German heterosexual male undergraduates right hand 2D:4D (but not left hand 2D:4D) was significantly negatively associated with reported lifetime NSP. The relationship between NSP and 2D:4D was independent of free testosterone, but free testosterone also showed a weak positive association with NSP (b) in a sample of 79 heterosexual and 95 homosexual Austrian men we found a significant negative association between right hand 2D:4D (but not left hand 2D:4D) and reported NSP in past year for heterosexual but not for homosexual men. The association in heterosexuals was independent of age, years of education, occupation and relationship status. We conclude that male NSP is likely to be influenced by the long-term organisational effects of prenatal testosterone. The relationship between NSP and 2D:4D appears to be confined to heterosexual men.

Adult↗
PubMed2005

Epidemiology of suicide in Austria 1990-2000: general decrease, but increased suicide risk for old men.

OBJECTIVES AND METHODS: The epidemiology of suicide in Austria, 1990-2000, was investigated. RESULTS: In comparison with 1980-1990, an overall decrease in the incidence of suicide was found. The annual averages for male, female, and total suicide rates were 32.2, 11.0, and 21.3, respectively, representing decreases of 17.6%, 25.7%, and 19.3%. Decreases were observed in all age groups except for males aged 80-84 years, where the suicide rate was 123.5 (15.1% increase), and for males aged 85 years or over, where the rate was 148.9 (25.4% increase). Hanging is still the most frequently used suicide method in Austria, despite steady decreases during recent decades. During the 1990s, hanging was used in 47.5% of male suicides and 34.8% of female cases. Shooting is the next most common method for male suicides (23.5% of cases) and has become more frequent for both sexes. CONCLUSIONS: The main findings reveal that the decrease in suicide incidence in Austria is greater for females than for males, reflecting the increased suicide risk within the oldest male age groups. This population subgroup should thus be a particular target for suicide-prevention efforts in Austria. A further aim within a national strategy for suicide prevention should be to stop the increased use of shooting as a suicide method.

Adolescent↗
PubMed2005

Digit ratio (2D:4D) in homosexual and heterosexual men from Austria.

Neurohormonal theories of sexual orientation emphasize the organizational effects of testosterone on the developing brain. A recent suggestion, that the ratio of the length of the 2nd and 4th digits (2D:4D) is negatively correlated with prenatal testosterone, has led to a number of studies of 2D:4D in homosexual and heterosexual men and women. The results have been mixed. In comparison to heterosexual men, mean 2D:4D in gay men has been reported to be hypermasculinized (lower 2D:4D), hypomasculinized (higher 2D:4D), or to show no significant difference. Here, we report mean 2D:4D in Austrian homosexual and heterosexual men. We found no significant difference between means for homosexual and heterosexual 2D:4D, with values for both falling between 0.96 to 0.97. There are now 6 reports of 2D:4D in heterosexual and homosexual men. Considering Caucasian men, the studies from the United States show low heterosexual mean 2D:4D, and homosexual mean 2D:4D is higher or similar to that of heterosexuals. The European studies show high heterosexual mean 2D:4D, and comparisons with homosexuals reveal the latter to have lower or similar mean 2D:4D to that of heterosexuals. We discuss these results in relation to the suggestion that mean 2D:4D in heterosexual men differs across populations but mean 2D:4D in homosexuals shows less geographical variation (the "uniform mean hypothesis"). It is concluded that more data are required to clarify whether or not there is a 2D:4D effect for sexual orientation in men.

Adult↗
PubMed2005

Experience with microvascular free flaps in preoperatively irradiated tissue of the oral cavity and oropharynx in 303 patients.

This study examined free flap reconstruction of surgical defects of the oral cavity and oropharynx after preoperative radiochemotherapy. Included in this analysis are 303 prospectively followed patients who underwent a multimodal treatment regime for advanced oral and oropharyngeal carcinoma. All patients received preoperative radiochemotherapy (Mitomycin C, 5-FU, 50 Gy), ablative surgery, and primary free flap reconstruction. Patient characteristics, surgical parameters like duration of surgery and ischaemia, size of defect, type of transplant, and clinical outcome parameters like duration of intensive care and hospitalization, type of complications, necessity and type of revision surgery were statistically evaluated. Overall flap success rate was 93.1%. Sixty seven patients required revision and 21 flaps (6.9%) were lost. Overall complication rate was 22.1%. Mean duration of intensive care (DOIC) and duration of overall postoperative hospitalization (DOH) were 11.0+/-9.6 days and 35.9+/-26.3 days, respectively. Flap success and flap related complications after 50 Gy focal radiation dosage were found in a comparable range as in published series of reconstructions in uncompromised tissue.

Adult↗
PubMed2005

An evaluation of the clinical application of three different biodegradable osteosynthesis materials for the fixation of zygomatic fractures.

OBJECTIVE: The aim of this prospective study was to compare the clinical handling of 3 different biodegradable osteosynthesis materials and to determine whether they can be used for the fixation of all types of zygomatic fractures. STUDY DESIGN: A total of 54 consecutive patients who presented with displaced fractures of the zygomatic bone between October 2001 and May 2003 were randomly allocated to 3 biodegradable material groups for the fixation of the fractures. A titanium fixation system was used as rescue osteosynthesis whenever biodegradable materials failed. RESULTS: Seventy-one (75.5%) of 94 fracture sites were fixed with biodegradable osteosynthesis; 23 (24.5%) had to be fixed with titanium plates and screws. No statistically significant difference was found between the 3 biodegradable materials with regard to their suitability for zygomatic fracture fixation (P = .16). Nonstable fixation (n = 7) or the need to fix small fragments (n = 16) were the reasons for using the titanium fixation system as rescue osteosynthesis at these sites. Biodegradable materials were most frequently unfeasible for use at the infraorbital rim and in the zygomaticomaxillary/anterior sinus wall area. CONCLUSIONS: It was possible to stabilize 3 of 4 zygomatic fractures with 1.5- or 1.7-mm biodegradable osteosynthesis. Insufficient fracture stabilization, especially at the infraorbital rim and the zygomaticomaxillary crest/anterior sinus wall, was the main reason to switch to titanium osteosynthesis. The biodegradable screw design is possibly too bulky for these particular bony structures.

Absorbable Implants↗
PubMed2005

National intelligence, suicide rate in the elderly, and a threshold intelligence for suicidality: an ecological study of 48 Eurasian countries.

Across 85 countries around the world, Voracek (2004) found a significant positive relation between estimated national intelligence (IQ) and national male and female suicide rate. The relation was not attenuated when countries' per capita Gross Domestic Product (GDP) and type of national IQ estimation were statistically controlled. Independently, investigating the total national suicide rate only, Lester (2003) arrived at the same conclusion. These two findings are consistent with a corollary of de Catanzaro's (1981) evolutionary theory of human suicide, namely that a threshold intelligence is necessary for suicidality and that intelligence and suicide mortality should thus be positively related. Here, further evidence for this hypothesis is bolstered by focusing on suicide rates of the elderly. Across 48 Eurasian countries, estimated national IQ was significantly positively related to national suicide rates of people aged 65 years and over. This new ecological-level finding survived statistical controlling for a set of seven variables (type of national IQ estimation, national GDP, stableness and recency measures for suicide rates, and rates of adult literacy, urbanization and Roman Catholics), which thus are not confounding factors for the relation of intelligence and suicide mortality. Based on ecological data, the threshold IQ for suicidality is predicted to be 70 or slightly over, an estimate that is consistent with various suicidological observations.

Aged↗
PubMed2005

Some problems of research on the association between blood types and suicide mortality: comment on Lester (2004).

This is a comment on the ecological finding of a negative association of national suicide rate and national proportion of people with Type O blood (Lester, 2004). Current knowledge on this topic is reviewed and several problems, limitations, and discrepancies within this research line are noted. Specifically, it is suggested that (1) this association appears to have been subject to attenuation recently; (2) available ecological evidence on this association is contradictory to both individual-level findings on the same topic and similar ecological-level findings pertaining to personality-related risk factors and antecedents of suicide; (3) a negative association of one of the four ABO phenotypes with suicide mortality does not help single out phenotypes with possibly increased suicide risk; and (4) genetic suicide risk factors may well be associated with other ABO phenotypes than Type O and may further coincide with other blood polymorphisms than the ABO system.

ABO Blood-Group System↗
PubMed2005

Increased occurrence of out-of-hospital cardiac arrest on Mondays in a community-based study.

Acute myocardial infarction and sudden cardiac death are more common on Mondays than other days of the week. The stress of returning to work at the beginning of the week has been postulated as a possible trigger factor. This project examined the weekly variation of out-of-hospital cardiac arrests of nontraumatic origin for the entire case series as well as for selected subgroups. A retrospective analysis of 1,498 incidences between January 1, 1995 and December 31, 1996 revealed a distinct Monday peak in occurrence irrespective of age, gender, presence of witnesses, primary survival, or primary ECG. This finding, however, was most pronounced in retired patients, subjects living alone, and persons found unconscious outside buildings or in public places. One important trigger of cardiac arrest is going to work after weekends; however, resumption of social and other activities on Mondays is another possible trigger. Other factors, such as endogenous biological rhythms, may contribute to an increased risk at this particular time even in elderly.

Aged↗
PubMed2005

Primary interpretation of thoracic MDCT images using coronal reformations.

OBJECTIVE: The objective of this study was to evaluate the accuracy and efficiency of primary interpretation of thoracic MDCT using coronal reformations as compared with transverse images. SUBJECTS AND METHODS: Fifty patients (18 females, 32 males; age range, 15-93 years; mean age, 63.6 years) underwent 4-MDCT of the chest (detector width, 1 mm; beam pitch, 1.5). Contrast material was administered in 20 of the 50 patients. Coronal and transverse sections were reformatted into 5-mm-thick sections at 3.5-mm intervals. All available image and clinical data consensually reviewed by two thoracic radiologists served as the reference standard. Subsequently, three other thoracic radiologists independently evaluated reformatted coronal and transverse images at two separate review sessions. Each image set was assessed in 58 categories for abnormalities of the lungs, mediastinum, pleura, chest wall, diaphragm, abdomen, and skeleton. Interpretation times and number of images assessed were recorded. Sensitivity, specificity, and interobserver concordance were calculated. Differences in mean sensitivities and specificities were evaluated with Wilcoxon's signed rank test. RESULTS: The most common findings identified were pulmonary nodules (n = 73, transverse images; n = 72, coronal images) and emphysema (n = 45, transverse; n = 40, coronal). The mean detection sensitivity of all lesions was significantly (p = 0.001) lower on coronal (44% +/- 26% [SD]) than on transverse (51% +/- 22%) images, whereas the mean detection specificity was significantly (p = 0.005) higher (96% +/- 5% vs 95% +/- 6%, respectively). Reporting findings for significantly (p < 0.001) fewer coronal images (mean, 63.0 +/- 4.6 images) than transverse images (mean, 91.9 +/- 8.8 images) took significantly (p = 0.025) longer (mean, 263 +/- 56 sec vs 238 +/- 45 sec, respectively). CONCLUSION: Primary interpretation of thoracic MDCT is less sensitive and more time-consuming using 5-mm-thick coronal reformations as compared with transverse images.

Adolescent↗
PubMed2005

Clark and Hatfield's evidence of women's low receptivity to male strangers' sexual offers revisited.

Although frequently cited, there has been no published scientific replication of Clark and Hatfield's (1989) and Clark's (1990) findings concerning women's low receptivity to male strangers' offers of casual sex. Consistently across three identically designed naturalistic experiments (aggregated N = 144), these authors reported a 0% acceptance rate by women. The present research analyzed an informal "real-life" journalistic project (N= 100) initiated by an Austrian magazine, in which results indicated a 6.1% acceptance rate (95% CI: 2.8-12.6%) for a complete stranger offering women immediate sexual involvement. Various contextual differences, such as setting, subjects' age and attractiveness, and age differences between requestor and receiver, probably contributed to the observed difference in outcome between the journalistic project and the original experiments. The present findings point to the importance of contextual effects in naturalistic investigations of women's receptivity to sexual offers.

Adult↗
PubMed2004

Austrian medical students' attitudes towards male and female homosexuality: a comparative survey.

BACKGROUND: The attitudes of health-care professionals and medical students towards male and female homosexuality are of practical relevance and have increasingly become a topic of scientific research. Comparative investigations between medical students and other student groups have not yet been conducted. OBJECTIVES: To assess the attitudes of Austrian medical students towards homosexuality and to compare these with the attitudes of students of politics and veterinary medicine. METHODS: Students of medicine (122), politics (145), and veterinary medicine (153) completed a questionnaire consisting of validated instruments assessing anti-homosexual attitudes, items assessing knowledge on homosexual issues, and basic demographic information. RESULTS: Participants' attitudes were predominantly positive. For all instruments, two-way analyses of covariance revealed significant influences of participants' sex and study major: students of medicine and veterinary medicine held more negative attitudes than students of politics, and males were more prejudiced than females. Overall, attitudes towards male and female homosexuality were balanced, but male students of politics and veterinary medicine were more prejudiced towards male than female homosexuality. A significant influence of participants' sex (favoring females) was observed in knowledge of homosexual issues. CONCLUSIONS: Although neutrality and empathy are considered vital in the doctor-patient relationship, medical students revealed more negative attitudes than students of politics did, the latter's attitudes being similar to those of students of veterinary medicine. These findings suggest that educational and correcting interventions are required in medical training.

Adolescent↗