Copper as an essential nutrient and nicotinic acid as the anti-black tongue (pellagra) factor: the work of Conrad Arnold Elvehjem.
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Anemia↗
Biomedical subjects
Martha Vaughan
Publications and source records attributed to Martha Vaughan.
The determination of phosphorus and the discovery of phosphocreatine and ATP: the work of Fiske and SubbaRow.
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Adenosine Triphosphate↗
Carbohydrate Metabolism: Glycogen Phosphorylase and the Work of Carl F. and Gerty T.Cori. 1928-1943.
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Biochemistry↗
A new sulfur-containing amino-acid isolated from the hydrolytic products of protein(Mueller, J. H. (1923) J. Biol. Chem. 56, 157-169).
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Biochemistry↗
On glutathione. II. A thermostable oxidation-reduction system (Hopkins, F. G., and Dixon, M. (1922) J. Biol. Chem. 54, 527-563).
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Biochemistry↗
The amino-acid minimum for maintenance and growth, as exemplified by further experiments with lysine and tryptophane (Osborne, T. B., and Mendel, L. B. (1916) J. Biol. Chem. 25, 1-12) and The role of vitamines in the diet (Osborne, T. B., and Mendel, L. B. (1917) J. Biol. Chem. 31, 149-163).
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Amino Acids↗
Comparative studies of the mode of oxidation of phenyl derivatives of fatty acids by the animal organism and by hydrogen peroxide (Dakin, H. D. (1908) J. Biol. Chem. 4, 419-435).
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Animals↗
Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity.
Cytokines regulate lymphocyte development and differentiation, but precisely how they control these processes is still poorly understood. By using microarray technology to detect cytokine-induced genes, we identified a cDNA encoding Cybr, which was increased markedly in cells incubated with IL-2 and IL-12. The mRNA was most abundant in hematopoietic cells and tissues. The predicted amino acid sequence is similar to that of GRP-1-associated protein (GRASP), a recently identified retinoic acid-induced cytohesin-binding protein. Physical interaction, dependent on the coiled-coil domains of Cybr and cytohesin-1, was demonstrated by coimmunoprecipitation of the overexpressed proteins from 293T cells. Cytohesin-1, in addition to its role in cell adhesion, is a guanine nucleotide-exchange protein activator of ARF GTPases. Acceleration of guanosine 5prime prime or minute-O-(thiotriphosphate) binding to ARF by cytohesin-1 in vitro was enhanced by Cybr. Because the binding protein modified activation of ADP ribosylation factor by cytohesin-1, we designate this cytokine-inducible protein Cybr (cytohesin binder and regulator).
Amino Acid Sequence↗
Cytohesin-1 in 2001.
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ADP-Ribosylation Factors↗
BIG1 and BIG2: brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors.
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ADP-Ribosylation Factor 1↗
ARF-directed guanine-nucleotide-exchange (GEP) proteins.
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ADP-Ribosylation Factors↗