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Biomedical subjects

Mark R Nelson

Publications and source records attributed to Mark R Nelson.

41 records · Page 3Linked to original sources
PubMed2002

Case report. Severe cutaneous ulceration secondary to cytomegalovirus inclusion disease during successful immune reconstitution with HAART.

Restoration of the immune system following HAART is not without its adverse effects. We describe a case of severe cutaneous ulceration secondary to cytomegalovirus (CMV) infection in an HIV-1-seropositive man following the initiation of HAART in the absence of active CMV retinitis and discuss the likely mechanisms associated with its development.

Adult↗
PubMed2002

Building the best regimen for highly treatment-experienced patients.

The use of highly active antiretroviral therapy (HAART) has dramatically reduced the mortality and morbidity associated with HIV infection. However, drug resistance remains the most important reason for virological failure and rapidly limits treatment options. Virus resistant to all three major antiretroviral drug classes is now reported even in primary seroconverters. In this article, the options for the management of highly treatment-experienced patients with multiple drug resistance are considered. Options discussed include whether to continue failing therapy, stop treatment in the hope of the virus reverting to wild type, the role of resistance testing in this setting, the impact of reduced viral fitness and the use of mega- and giga-HAART.

Antiretroviral Therapy, Highly Active↗
PubMedDate not supplied

Implementing a research governance framework for clinical and public health research.

Research conduct in Australia and worldwide is mostly unaudited. The purpose of good research governance is to ensure integrity in research through accountability, transparency and responsibility. Institutional responsibility for research governance has been adopted by Monash University's Department of Epidemiology and Preventive Medicine, providing clear lines of accountability for researchers as well as support and guidance. A research audit tool has been developed, identifying areas where practice could be improved especially among less experienced researchers; the most common adverse findings concerned research protocols and procedure manuals. The need for participant confidentiality, privacy and data security was found to be understood, and adhered to widely by all researchers. An evaluation of the effect of audit on researchers found that the process was well accepted.

Australia↗