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Biomedical subjects

Mark P Hatton

Publications and source records attributed to Mark P Hatton.

23 records · Page 2Linked to original sources
PubMedDate not supplied

Gene therapy for genetic and acquired retinal diseases.

We present an overview of the current status of basic science and translational research being applied to gene therapy for eye disease, focusing on diseases of the retina. We discuss the viral and nonviral methods being used to transfer genes to the retina and retinal pigment epithelium, and the advantages and disadvantages of each approach. We review the various genetic and somatic treatment strategies that are being used for genetically determined and acquired diseases of the retina, including gene replacement, gene silencing by ribozymes and antisense oligonucleotides, suicide gene therapy, antiapoptosis, and growth factor therapies. The rationales for the specific therapeutic approaches to each disease are discussed. Schematics of gene transfer methods and therapeutic approaches are presented together with a glossary of gene transfer terminology.

Eye Diseases, Hereditary↗
PubMedDate not supplied

Symmetry in healing after bilateral eyelid surgery.

PURPOSE: To determine whether surgery performed bilaterally (ptosis repair, blepharoplasty, or both) results in symmetric healing. METHODS: Case series of 19 consecutive patients undergoing bilateral ptosis repair, blepharoplasty, or both. Patients were provided with questionnaires to determine their perception of the degree of symmetry in healing at four time points after bilateral surgery. Digital imaging analysis was used to measure the amount of bruising present on each side in a separate cohort of 10 patients undergoing bilateral eyelid surgery. RESULTS: Asymmetry in bruising, swelling, and discomfort was reported by the majority of patients at each time point after surgery. For each measure (bruising, swelling, and discomfort), the percentage of patients reporting asymmetry peaked at day 3. Objective measurement 7 days after surgery showed that 50% of patients had more bruising on the right and 50% had more bruising on the left. The difference in the average area of bruising was not statistically significant between sides. Eight of 10 patients had less than a 10% difference in area of bruising between sides. CONCLUSIONS: Patients frequently perceive asymmetry in healing after bilateral eyelid surgery, but objective measurements show that asymmetry in bruising is typically small.

Blepharoplasty↗
PubMedDate not supplied

When is enophthalmos "significant"?

PURPOSE: It is currently unknown how many measurable millimeters of enophthalmos may be noticeable to an observer. Identifying the amount of enophthalmos present may help to guide patients and clinicians in regard to surgical management of enophthalmos. METHODS: The Massachusetts Eye and Ear Infirmary Oculoplastics imaging database was used to select 12 photographs of patients with unilateral enophthalmos whose measurements ranged between 1 mm and 8 mm for the study group and 12 photographs of patients who did not have enophthalmos as the control group. Observers were asked to review each of the photographs from both groups and to comment on whether the appearance was normal or abnormal. RESULTS: There was no statistical difference found when observers reviewed photographs from the control group and patients whose measurements ranged between 1 mm and 2 mm (87%, 83% respondents identifying patients as normal, respectively). Twenty-eight percent of observers found patients with 3 mm and 4 mm of enophthalmos as having a normal appearance (P < 0.001). Ninety-seven percent of observers commented that patients with measurements of 5 mm and 8 mm had an abnormal appearance (P < 0.001). CONCLUSIONS: Patients with 2 mm and less of measurable enophthalmos had a normal appearance as frequently as those without enophthalmos. Nearly all patients with measurements of 5 mm and greater had abnormal appearances. The point at which enophthalmos becomes detectable lies between 3 mm and 4 mm.

Enophthalmos↗