Mark D Diltz | Search PubMed

PubMed2006

Integration of auditory and visual communication information in the primate ventrolateral prefrontal cortex.

The integration of auditory and visual stimuli is crucial for recognizing objects, communicating effectively, and navigating through our complex world. Although the frontal lobes are involved in memory, communication, and language, there has been no evidence that the integration of communication information occurs at the single-cell level in the frontal lobes. Here, we show that neurons in the macaque ventrolateral prefrontal cortex (VLPFC) integrate audiovisual communication stimuli. The multisensory interactions included both enhancement and suppression of a predominantly auditory or a predominantly visual response, although multisensory suppression was the more common mode of response. The multisensory neurons were distributed across the VLPFC and within previously identified unimodal auditory and visual regions (O'Scalaidhe et al., 1997; Romanski and Goldman-Rakic, 2002). Thus, our study demonstrates, for the first time, that single prefrontal neurons integrate communication information from the auditory and visual domains, suggesting that these neurons are an important node in the cortical network responsible for communication.

Acoustic Stimulation↗

PubMed2004

Can delay-period activity explain working memory?

Working-memory tasks often lead to elevated delay-period discharge rates in cortical neurons. When this altered neuronal discharge rate, called delay activity, shows stimulus specificity, it is a good candidate for a neuronal mechanism of working memory. If the delay activity is indeed the carrier of memory, then experimental manipulation during the delay period that disrupts delay activity should also disrupt behavioral performance. We tested this hypothesis in two macaque monkeys with a delayed matching-to-sample task (delay time: 8 or 10 s) in which only two visual images were used. In each trial, one of the images was randomly chosen as the sample. In control trials (without disruptive stimulation), the monkeys performed at the level of 74.3% correct recognition. Three electrical stimulation levels (mild: a 0.25-s train of electrical pulses; medium: 1-s train; strong: 4 s), delivered to the hippocampal formation or to the orbito-frontal and inferotemporal cortices during delay period, decreased the performance to 71.4, 66.8, and 58.0% respectively (all are significantly less than control performance, P < 0.05 for mild stimulation and P < 0.0001 for other stimulation levels). Three hundred and thirty-four cells were recorded from inferotemporal (211 cells) and prefrontal (123 cells) cortices. Significant (P < 0.05) stimulus-specific delay activity was found in about one-third of recorded cells. For these cells in control trials, the mean difference in delay-period spike rates between preferred and nonpreferred images was 26%. The electrical stimulation reduced this difference to 20% (not a statistically significant reduction) in trials with mild stimulation, to 14% (P < 0.05) with medium stimulation, and just to 4% (P < 0.0005) with strong stimulation. These results, that increasing electrical stimulation reduced neuronal selectivity and at the same time reduced behavioral performance, directly support the hypothesis that delay activity is the carrier of memory through the delay period.

Action Potentials↗