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Biomedical subjects

Marcin Adamczak

Publications and source records attributed to Marcin Adamczak.

23 records · Page 2Linked to original sources
PubMed2002

[Influence of aging on plasma leptin concentration].

Aging is associated both with clinically important hormonal changes and with a decrease of energy expenditure. Leptin is a protein hormone, predominantly produced by adipocytes, which is presumed to be involved in the regulation of appetite and energy expenditure. The present study aimed to assess the relationship between leptinaemia and age. 144 healthy subjects (72 females and 72 males) age from 20 to 93 years were enrolled in this study. All studied subjects were divided according to the age into five groups (group A comprised subjects aged 20 to 40 years, group B--from 41 to 60 years, group C--from 61 to 70 years, group D--from 71 to 80 years and group E--aged over 81 years). In all examined subjects plasma leptin, insulin and glucose concentrations were estimated at 8 a.m., 4 p.m. and 12 p.m. respectively. Body mass index (BMI) was also calculated in all studied subjects. Basal (8 a.m.) plasma leptin concentration did not differ significantly in all age groups: A = 10.4 +/- 1.33; B = 12.5 +/- 2.18; C = 9.8 +/- 1.48; D = 14.4 +/- 3.12; E--10.5 +/- 1.99 ng/ml). In all examined groups plasma leptin concentrations were significantly higher at 12 p.m. than at 8 a.m. and 4 p.m. respectively. Females were characterized by significantly higher plasma leptin concentration in all age groups. A significant positive correlation was found between plasma leptin concentration and BMI in all age groups (except group A). No relationship between age and plasma leptin concentration were found, as analyzed both by correlation and multivariate regression analysis, respectively. From results obtained in this study we may conclude that age does not influence significantly leptinaemia.

Adult↗
PubMed2002

Effect of renin-angiotensin system activation by dietary sodium restriction and upright position on plasma leptin concentration in patients with essential hypertension.

BACKGROUND: Both leptin and the renin-angiotensin system (RAS) are involved in the regulation of arterial blood pressure. This study was undertaken to assess the relationship between RAS and plasma leptin concentration in hypertensive patients under conditions of normal and restricted sodium supply and upright position. MATERIAL/METHODS: In 31 patients with essential hypertension (EHP - 14 F, 17 M, age 44I14 years, BMI 29.3I6.4 kg/m2) and 8 healthy subjects (NHS - 4 F, 4 M, age 37(17 years, BMI 25.3I6.6 kg/m2) plasma leptin concentration, plasma renin activity (PRA), and 24-hour urinary sodium excretion (UNa) were evaluated twice: first on a diet containing 100-120 mmol sodium per day and after 8 hours overnight bed rest, and a second time after 3 days of dietary sodium restriction (10-20 mmol daily) and 3 hours in upright position. RESULTS: Dietary sodium restriction and upright position was followed by a significant increase in PRA and decrease of UNa. By contrast, plasma leptin concentration showed a moderate decrease both in EHP and NHS. No significant correlation was found between PRA and plasma leptin concentrations in either of the groups examined. CONCLUSIONS: From the results obtained in this study we may conclude that dietary sodium restriction and upright position exerts only a moderate effect on plasma leptin concentration, in contrast to PRA, in both hypertensive and normotensive subjects.

Adult↗
PubMedDate not supplied

Mediators of inflammatory and ischemic renal damage: the role of neoangiogenesis.

Neoangiogenesis is at the forefront of research in a number of fields that are of interest to the nephrologist, ranging from the development of the kidney and glomerulus to microvascular injury and its repair. The molecular mechanisms have recently been elucidated to a considerable extent. They are relevant for understanding the link between endothelial cells and podocytes, which underlie the glomerular barrier function. For reasons poorly understood capillarogenesis is defective in renal failure.

Animals↗