Biomedical subjects

Marc H Gorelick

Publications and source records attributed to Marc H Gorelick.

At least 19 recordsLinked to original sources

PubMed2006

The kappa statistic was representative of empirically observed inter-rater agreement for physical findings.

BACKGROUND AND OBJECTIVE: To determine empirically chance agreement between different clinicians evaluating physical examination findings in children with acute abdominal pain. MATERIALS AND METHODS: Cross-sectional study of children age 3 to 18 years treated in a pediatric emergency department for acute abdominal pain. Three different examiners were provided the same historic information and asked to predict, independently and prior to examining the patient, the presence or absence of seven different clinical findings. Agreement between pairs of observers on these predicted findings was determined, and was defined as observed chance agreement. Actual examination findings were also recorded, and expected agreement due to chance was determined from the kappa statistic calculation. RESULTS: There were 68 pair of observations between two pediatric examiners, and 46 pair between pediatric and surgical examiners. Observed and expected chance agreement were very similar for six of the seven clinical findings. Agreement beyond chance for the actual exam findings was generally poor, with kappa less than 0.5 for all but one finding. CONCLUSIONS: Expected chance agreement, as calculated from the kappa statistic, is a reasonable reflection of empirically observed chance agreement between clinicians.

Abdominal Pain↗

PubMed2006

The decision to use topical anesthetic for intravenous insertion in the pediatric emergency department.

OBJECTIVES: Topical anesthetic creams to reduce the pain of intravenous (IV) placement may be more effectively used in the emergency setting if they are applied by nurses in the triage area of the emergency department or soon after the patient is placed into a room. This strategy requires accurate prediction of which patients will require IV placement. The objective of this study was to compare triage nurse judgment regarding IV placement in pediatric patients with a triage prediction rule using chief complaint, referral status, and high-risk medical history. A secondary objective was to evaluate whether the presence of the anesthetic cream placed in triage influenced the subsequent decision to place an IV and thus invalidate the prediction strategy. METHODS: Triage nurses were randomly assigned to a prediction score group (PRD), classifying patients as "IV likely" if the prediction score was > or =2, or an "own judgment" (RN JDGMT) group, classifying any patient that he or she considered to have a > or =50% risk of receiving an IV. The rate of actual IV placement in the emergency department treatment rooms was compared between the triage prediction strategies. To assess the influence of the presence of lidocaine 2.5% and prilocaine 2.5% (EMLA cream) on the judgment to place an IV, only 75% of the "IV likely" patients had EMLA applied in triage; the IV placement rate was compared between "IV likely" patients who did or did not have EMLA applied. RESULTS: The authors enrolled 3,790 of 5,025 (75.4%) of eligible patients. The RN JDGMT group predicted 165 of 250 (66%; 95% confidence interval = 59% to 72%) of IVs placed, compared with 127 of 305 (41%; 95% CI = 36% to 47%) in the PRD group (p < 0.0001). Positive predictive values were 59% and 53% for the RN JDGMNT and PRD groups, respectively. There was no difference in IV placement rates in the "IV likely" patients who did and did not have EMLA applied. CONCLUSIONS: Triage nurse judgment to predict eventual IV placement had greater sensitivity and similar predictive value compared with a prediction model based on medical history and chief complaint. The triage placement of topical anesthetic in pediatric patients did not change the eventual rate of IV placement.

Administration, Topical↗

PubMed2006

Bias arising from missing data in predictive models.

OBJECTIVE: The purpose of this study is to determine the effect of three common approaches to handling missing data on the results of a predictive model. STUDY DESIGN AND SETTING: Monte Carlo simulation study using simulated data was used. A baseline logistic regression using complete data was performed to predict hospital admission, based on the white blood cell count (WBC) (dichotomized as normal or high), presence of fever, or procedures performed (PROC). A series of simulations was then performed in which WBC data were deleted for varying proportions (15-85%) of patients under various patterns of missingness. Three analytic approaches were used: analysis restricted to cases with complete data, missing data assumed to be normal (MAN), and use of imputed values. RESULTS: In the baseline analysis, all three predictors were all significantly associated with admission. Using either the MAN approach or imputation, the odds ratio (OR) for WBC was substantially over- or underestimated depending on the missingness pattern, and there was considerable bias toward the null in the OR estimates for fever. In the CC analyses, OR for WBC was consistently biased toward the null, OR for PROC was biased away from the null, and the OR for fever was biased toward or away from the null. Estimates for overall model discrimination were substantially biased using all analytic approaches. CONCLUSIONS: All three methods of handling large amounts of missing data can lead to biased estimates of the OR and of model performance in predictive models. Predictor variables that are measured inconsistently can affect the validity of such models.

Adolescent↗

PubMed2006

Epidemiology of a pediatric emergency medicine research network: the PECARN Core Data Project.

OBJECTIVE: To examine the epidemiology of pediatric patient visits to emergency departments (ED). METHODS: We conducted a cross-sectional study of pediatric ED visits at the participating Pediatric Emergency Care Applied Research Network (PECARN) hospitals in 2002. We provide descriptive characteristics of pediatric ED visits and a comparison of the study database to the National Hospital Ambulatory Medical Care Survey (NHAMCS). Bivariate analyses were calculated to assess characteristics associated with hospital admission, death in the ED, and length of ED visit. We also performed multivariate regression to model the likelihood of admission to the hospital. RESULTS: Mean patient age was 6.2 years; 53.5% were boys; 47.5% black; and 43.2% had Medicaid insurance. The most common ED diagnoses were fever, upper respiratory infection, asthma, otitis media, and viral syndromes. The inpatient admission rate was 11.6%. The most common diagnoses requiring hospitalization were asthma, dehydration, fever, bronchiolitis, and pneumonia. In multivariate analysis, patients who were black or Hispanic, had Medicaid insurance or were uninsured, or were older than 1 year were less likely to be hospitalized. Demographics of the PECARN population were similar to NHAMCS, with notable exceptions of a larger proportion of black patients and of admitted patients from the PECARN EDs. CONCLUSION: We describe previously unavailable epidemiological information about childhood illnesses and injuries that can inform development of future studies on the effectiveness, outcomes, and quality of emergency medical services for children. Most pediatric ED patients in our study sought care for infectious causes or asthma and were discharged from the ED. Hospital admission rate differed according to age, payer type, race/ethnicity, and diagnosis.

Adolescent↗

PubMed2006

Emergency Department Allies: a Web-based multihospital pediatric asthma tracking system.

OBJECTIVE: To describe the development of a Web-based multihospital pediatric asthma tracking system and present results from the initial 18-month implementation of patient tracking experience. DESIGN: The Emergency Department (ED) Allies tracking system is a secure, password-protected data repository. Use-case methodology served as the foundation for technical development, testing, and implementation. Seventy-seven data elements addressing sociodemographics, wheezing history, quality of life, triggers, and ED managment were included for each subject visit. SETTING: The ED Allies partners comprised 1 academic pediatric ED and 5 community EDs. POPULATION: Subjects with a physician diagnosis of asthma who presented to the ED for acute respiratory complaints composed the asthma group; subjects lacking a physician diagnosis of asthma but presenting with wheezing composed the wheezing group. RESULTS: The tracking-system development and implementation process included identification of data elements, system database and use case development, and delineation of screen features, system users, reporting functions, and help screens. For the asthma group, 2005 subjects with physician-diagnosed asthma were enrolled between July 15, 2002 and January 14, 2004. These subjects accounted for 2978 visits; 10.4% had > or = 3 visits. Persistent asthma was noted in 68% of the subjects. During the same time period, 1297 wheezing subjects with a total of 1628 ED visits (wheezing group) were entered into the tracking system. After enrollment, 57% of the subjects with > or = 1 subsequent ED visits received a physician diagnosis of asthma. CONCLUSIONS: Our sophisticated tracking system facilitated data collection and identified key intervention opportunities for a diverse ED wheezing population. A significant asthma burden was identified with significant rates of hospitalization, acute care visits and persistent asthma in 68% of subjects. The surveillance component provided important insights into health care issues of both asthmatic subjects and wheezing subjects, many of whom subsequently were diagnosed with asthma.

Asthma↗

PubMed2006

National Asthma Education and Prevention Program severity classification as a measure of disease burden in children with acute asthma.

OBJECTIVE: To examine the association between the National Asthma Education and Prevention Program (NAEPP) severity classification and other measures of burden of disease in children with acute asthma. METHODS: We performed a cross-sectional study of 750 children <18 years of age with a physician diagnosis of asthma and treated in an emergency department (ED) for acute asthma exacerbation. Subjects were assigned to 1 of 4 levels of severity (mild intermittent, mild persistent, moderate persistent, or severe persistent). Assignments followed 3 methods: the report of symptom frequency alone (standard method); symptom frequency and reported controller-medication use (modified method); or the additive modified method in which the symptom frequency and reported controller-medication use were assigned numeric values and a score was calculated. An asthma-specific quality-of-life score was calculated by using the Integrated Therapeutics Group Child Asthma Short Form (ITG-CASF). The number of ED visits and hospital admissions for asthma over the previous 12 months was collected also. Differences between severity groups were compared with analysis of variance, and the proportion of variance explained (r2) was calculated. RESULTS: Using the standard classification method, 55% of subjects had mild intermittent asthma, 21% had mild persistent asthma, 14% had moderate persistent asthma, and 10% had severe persistent asthma. Among those classified as having mild intermittent asthma by symptoms alone, 22% were reclassified as having persistent asthma when controller medications were accounted for. With all 3 scoring methods, mean ITG-CASF scores decreased significantly with each increasing level of severity. However, the magnitude of this association was modest. There was a significant but limited association between severity level and mean number of ED visits and hospitalizations. CONCLUSION: NAEPP severity classification alone provides an incomplete picture of the burden of disease in children with asthma.

Anti-Asthmatic Agents↗

PubMed2006

Emergency department allies: a controlled trial of two emergency department-based follow-up interventions to improve asthma outcomes in children.

OBJECTIVE: We sought to study the impact of emergency department (ED)-based intensive primary care linkage and initiation of asthma case management on long-term, patient-oriented outcomes for children with an asthma exacerbation. METHODS: Our study was a randomized, 3-arm, parallel-group, single-blind clinical trial. Children aged 2 through 17 years treated in a pediatric ED for acute asthma were randomly assigned to standard care (group 1), including patient education, a written care plan, and instructions to follow up with the primary care provider within 7 days, or 1 of 2 interventions. Group 2 received standard care plus assistance with scheduling follow-up, while group 3 received the above interventions, plus enrollment in a case management program. OUTCOMES: The primary outcome was the proportion of children having an ED visit for asthma within 6 months. Other outcomes included change in quality-of-life score and controller-medication use. RESULTS: Three hundred fifty-two children were enrolled; 78% completed follow-up, 69% were black, and 70% had persistent asthma. Of the children, 37.8% had a subsequent ED visit for asthma, with no difference among the treatment groups (group 1: 38.4%; group 2, 39.2%; group 3, 35.8%). Children in all groups had a substantial, but similar, increase in their quality-of-life score. Controller-medication use increased from 69.4% to 81.4%, with no difference among the groups. CONCLUSION: ED-based attempts to improve primary care linkage or initiate case management are no more effective than our standard ED care in improving subsequent asthma outcomes over a 6-month period.

Adolescent↗

PubMed2006

Pain assessment for pediatric patients in the emergency department.

OBJECTIVE: To examine the relationship between pediatric patient visit characteristics and pain score documentation in the emergency department (ED) and determine whether documentation of a pain score is associated with increased analgesic use. METHODS: A cross-sectional analysis was conducted of ED visits for pediatric patients from the National Hospital Ambulatory Medical Care Survey (1997-2000). Survey weighted regression first was used to assess the association between patient visit characteristics and pain score documentation. The regression then was repeated to determine the association between documentation of a pain score and analgesic use, adjusting for visit characteristics. RESULTS: A total of 24,707 visits were included. Only 44.5% of visits had documented pain scores. In the regression analysis, younger age, self-pay, visits to pediatric facilities, and visits that were not designated as injury related were associated with decreased pain score documentation. Documentation of pain score was associated with increased odds of an analgesic prescription and opioid prescription. When no pain score was documented, the odds of receiving any analgesic was similar to visits with pain documented as mild. CONCLUSION: ED pain score documentation is suboptimal in the pediatric population. Infants and toddlers are at particular risk for not having a pain score documented. There is a significant association between pain score documentation and the use of any analgesic, particularly opioids. Improvements in pain documentation for acutely ill and injured children are needed to improve pain management.

Adolescent↗

PubMed2005

Availability of pediatric emergency visit data from existing data sources.

OBJECTIVES: To determine the availability and completeness of selected data elements from administrative and clinical sources for emergency department (ED) visits in a national pediatric research network. METHODS: This was a retrospective study of 25 EDs in the Pediatric Emergency Care Applied Research Network. Data were obtained from two sources at each ED: 1) extant electronic administrative data for all visits during a 12-month period in 2002 and 2) data abstracted from medical records by trained abstractors for visits during ten randomly selected days over a three-month period in 2003. Epidemiologic data were obtained for all visits and additional clinical data for patients with two target conditions: asthma and fractures. RESULTS: A total of 749,036 visits were analyzed from administrative sources and 12,756 medical records abstracted. Data availability varied by element, method of capture, and site. From administrative sources, data on insurance type were the most complete (1.3% overall missing; range, 0%-18.5% for individual sites), whereas mode of arrival (25.5% missing) and triage time (65.3%) were the least complete. Disposition was missing in only 1.2% of medical records overall (range, 0%-5%) and diagnosis was missing in 3% (range, 0%-16%); these were missing from 14.4% and 10.5%, respectively, of administrative sources. Among visits with injury diagnoses, E-codes were missing in 27% of cases. For patients with asthma (n = 861), documentation of specific elements of the clinical examination by nurses and physicians was also variable. CONCLUSIONS: Data elements important in emergency medical care for children are frequently missing in existing administrative and medical record sources; completeness varies widely across EDs. Researchers must be aware of these limitations in the use of existing data when planning studies.

Data Collection↗

PubMed2005

Interexaminer reliability in physical examination of pediatric patients with abdominal pain.

OBJECTIVE: To test the interexaminer reliability of abdominal examinations performed by pediatric emergency medicine physicians and surgeons in an emergency department. METHODS: A prospective cross-sectional study in which 3 different types of physicians (pediatric emergency department residents, pediatric emergency department attending physicians, and pediatric surgeons in training) independently examined a convenience sample of children (aged 3-19 years) with initial complaint of abdominal pain. The interexaminer reliability of 6 components of the abdominal examination (the presence or absence of abdominal distension, abdominal tenderness to percussion, abdominal tenderness to palpation, abdominal guarding, rebound tenderness, and bowel sounds) and the clinical diagnosis of peritonitis was tested. RESULTS: Sixty-eight patients were examined by pediatric emergency department residents and pediatric emergency department attending physicians. All 3 physician types examined 46 of these 68 patients. When comparing residents and attending physicians, the components of the abdominal examination showed less than moderate chance-adjusted agreement (kappa range, -0.04 to 0.38). When comparing attending physicians and surgeons, the presence of rebound tenderness showed moderate agreement (kappa = 0.54). The rest of the components demonstrated less than moderate chance-adjusted agreement (kappa range, -0.04 to 0.34). CONCLUSIONS: The components of the abdominal examination are poorly reliable between physician types. Only the "rebound tenderness" component of the abdominal examination shows moderate agreement between the pediatric emergency department attending physicians and the surgeon. No component of the abdominal examination appears to be consistently reliable. Interexaminer agreement must be considered when developing management strategies for acute abdomen. Interventions to improve reliability should be developed.

Abdominal Pain↗

PubMed2005

The effect of in-room registration on emergency department length of stay.

STUDY OBJECTIVE: Length of stay is a measure of efficiency of delivery of care and is an important determinant of patient satisfaction in a pediatric emergency department (ED). Although length of stay is affected by many unmodifiable factors, changes in care processes may lead to improvements in throughput. Evaluating the success of such changes, however, requires an understanding of the effect of other determinants. We determine the factors associated with ED length of stay and estimate the effect of an in-room registration process on throughput time. METHODS: This was a before-and-after study at an academic pediatric ED with annual census of 45,000 visits. The study period was January 2, 2000, through December 31, 2003. In June 2003, an in-room registration process was initiated so that patients were placed directly into a room after triage, and the registration process was completed after physician evaluation. Weekly data were obtained on average length of stay and the following possible confounders: average daily ED census, hospital admissions from the ED, hospital occupancy rate, hours of physician staffing, and month of the year. An autoregressive integrated moving-average time series model was used to determine the effect of each variable on length of stay. RESULTS: Data were obtained for 209 weekly intervals during the study period; average length of stay ranged from 2.2 to 3.8 hours. All factors were highly associated with length of stay except for the number of hours of physician staffing (P =.71). The presence of in-room registration led to an estimated average decrease in length of stay of 15.0 minutes (95% confidence interval 6.3 to 33.4 minutes), or 9.3%. CONCLUSION: In-room registration leads to a statistically significant and practically meaningful improvement in total length of stay in the pediatric ED. Throughput time can be largely explained by a limited number of factors; our predictive model may facilitate the evaluation of other interventions.

Emergency Service, Hospital↗

PubMed2005

Serum neuron-specific enolase as a predictor of short-term outcome in children with closed traumatic brain injury.

BACKGROUND: Closed traumatic brain injury (cTBI) is a significant cause of mortality and morbidity in children. The natural course and extent of recovery from cTBI in children are poorly understood. Neuron-specific enolase (NSE), an enzyme detected in serum following structural damage of neuronal brain cells, appears to be a good marker for intracranial injury. However, to the best of the authors' knowledge, the usefulness of NSE as a predictor of disability in children with cTBI has not been reported. OBJECTIVES: To examine the association between posttraumatic serum NSE level and short-term physical disability in children with cTBI. METHODS: This was a retrospective analysis of a prospectively enrolled cohort of children aged 0-18 years with isolated cTBI presenting to the emergency department (ED) within 24 hours of injury, and having a cranial computed tomography (CT) scan as part of the evaluation. The NSE level was obtained at the time of ED evaluation. Physical disability was measured using the Glasgow Outcome Scale (GOS). The GOS score was assigned retrospectively for enrolled patients by a single investigator blinded to NSE level. Patient outcomes were categorized as good (GOS = 5) or poor (GOS < 5). A single radiologist reviewed all cranial CT scans. RESULTS: Ninety eligible subjects with NSE levels were identified; 86 met the enrollment criteria. Seven subjects (8%) had poor outcome. There was a significant difference in NSE levels between the poor and good outcome groups, even within high-risk subgroups. The area under the curve (AUC) for NSE prediction of poor vs. good outcome was 0.83. A serum NSE level of 21.2 ng/dL was 86% sensitive and 74% specific in predicting poor outcome. CONCLUSIONS: It appears that the serum NSE level can be used as a predictor of global short-term physical disability in children following cTBI.

Adolescent↗

PubMed2005

A system for grouping presenting complaints: the pediatric emergency reason for visit clusters.

OBJECTIVES: To develop a set of chief complaint groupings for pediatric emergency department (ED) visits that is comprehensive, parsimonious, clinically sensible, and evidence-based. METHODS: Investigators derived candidate chief complaint clusters and ranked them a priori into three perceived severity categories. Pediatric visits were extracted from the National Hospital Ambulatory Medical Care Survey (NHAMCS); data for years 1998 and 2000 (n = 13,186) were used for derivation and data for year 1999 (n = 5,365) were used for validation. Visits were assigned to clusters based on the recorded complaints; clusters were combined to ensure adequate numbers for analysis (minimum n = 20), and the clusters were reviewed for clinical sensibility. Resource utilization was categorized in three levels: routine (examination only), ED treatment (tests or therapy in the ED but not admitted), and admission. Area under the receiver-operating characteristic (ROC) curve (AUC) was used to demonstrate the discriminative ability of the clusters in predicting resource use. RESULTS: There were 463 unique complaints in the derivation database; 95 (20%) had a single associated visit. Fifty-two clusters were generated; only 2.4% of complaints were classified as other. The eight most common clusters encompassed 52% of the visits. The top five were fever (11%), extremity pain/injury, vomiting, cough, and trauma (unspecified). Complaint clusters were associated with actual resource utilization: for routine care, the AUC was 0.73 (0.74 in the validation set), and for admission, the AUC was 0.77 (0.74 in the validation set). Both resource utilization and triage classification increased with increased expert severity ranking (test for trend, p < 0.001). CONCLUSIONS: The proposed Pediatric Emergency Reason for Visit Cluster (PERC) system is a comprehensive yet parsimonious, clinically sensible means of categorizing pediatric ED complaints. The PERC system's association with measures of acuity and resource utilization makes it a potentially useful tool in epidemiologic and health services research.

Adolescent↗

PubMed2005

Intervention to improve interobserver agreement in the assessment of children with pharyngitis.

OBJECTIVE: The objective of this study is to examine the effectiveness of an intervention to improve interobserver reliability of clinical evaluation of children with pharyngitis. METHODS: This was a sequential trial performed in an academic children's hospital emergency department. Two sets of 100 children aged 2 to 18 years with a complaint of sore throat were independently evaluated by emergency department attending staff and residents for coryza, scarlatiniform rash, tonsillar enlargement, tonsillar erythema, tonsillar exudates, cervical adenopathy, and palatal petechiae. The first 100 subjects were evaluated according to the clinician's routine practice; the second set was evaluated using a visual-aid sheet showing pictorial gradations of each characteristic. All findings were scored dichotomously and analyzed by kappa statistics. RESULTS: Both sets of patients were similar with respect to age, sex, race, and prior episodes of group A beta-hemolytic streptococcus. Interobserver reliability without the visual aid was poor in all areas except tonsillar enlargement and tonsillar exudates which had kappa values of 0.50 and 0.58, respectively. The use of the visual-aid sheet did not significantly improve reliability in any of the clinical evaluations, and all kappa scores remained below 0.50. CONCLUSION: Interobserver reliability in evaluating clinical signs of pharyngitis is fair to poor. The use of pictorial prompts does not improve interobserver reliability.

Adolescent↗

PubMed2004

The effect of prior interactions with a primary care provider on nonurgent pediatric emergency department use.

OBJECTIVE: To determine the effect of parental reported difficulty getting care without long waits from a primary care provider (PCP) on nonurgent pediatric emergency department (ED) use. DESIGN: Case-control study. SETTING: Pediatric ED within an urban pediatric hospital. PARTICIPANTS: Children, aged 6 months to 12 years, who presented with a chief complaint from a predetermined list of nonurgent (cases) or emergent complaints (controls). MAIN OUTCOME MEASURES: Caregivers assessed interactions with a PCP during the previous 12 months by completion of a Consumer Assessment of Health Plans (CAHPS) survey. Baseline demographic variables were compared. Composite CAHPS scores assessing difficulty meeting medical needs, including getting care without long waits, were compared using median tests. Multivariate logistic regression was used to assess the effect of getting care without long waits on nonurgent ED use. RESULTS: Of 821 caregivers approached, 719 (87.6%) completed the survey, including 366 cases (50.9%) and 353 controls (49.1%). Those with emergent complaints were older, healthier, and more likely to be male; had higher caregiver education and income levels; and were more likely to have a PCP. Analysis of the CAHPS composite scores revealed increased difficulty meeting medical needs for those with nonurgent complaints, with the greatest difference noted for getting care without long waits (median score, 3.25 vs 3.67; P<.001). In multivariate regression, increased ability to get care without long waits was associated with decreased odds of nonurgent ED use (odds ratio, 0.48; 95% confidence interval, 0.32-0.72). CONCLUSION: Parental-reported previous difficulty getting care without long waits from a PCP is a risk factor for nonurgent ED use.

Caregivers↗

PubMed2004

Emergency department management of sexually transmitted infections in US adolescents: results from the National Hospital Ambulatory Medical Care Survey.

STUDY OBJECTIVE: Adolescents are at risk for developing a variety of sexually transmitted infections for many reasons. Many of these adolescents present to the emergency department (ED) for their care. We describe the management of adolescent sexually transmitted infections in US EDs. METHODS: Data were obtained from the 1992 to 1998 National Hospital Ambulatory Medical Care Survey. All visits by adolescents aged 12 to 19 years were identified by any International Classification of Diseases, Ninth Revision code related to sexually transmitted infections. Treatment was reviewed and compared with existing guidelines from the US Centers for Disease Control and Prevention (CDC). Multivariate logistic regression was used to determine the independent association of each of the following variables on antibiotic prescribing rates: sex, race and ethnicity, hospital location, age, and insurance. RESULTS: Eighteen thousand nine hundred ninety-nine records that represented 70,693,603 adolescent visits to US EDs were identified during the 7-year study period, of which 351 records representing 1.2 million visits were for a sexually transmitted infection. Mean age was 17.1 years, and 92% were female patients. Overall, 80% of patients diagnosed with a sexually transmitted infection were treated (received antibiotics or were admitted to the hospital); 91% of patients had pelvic inflammatory disease and 71% of patients had other sexually transmitted infections. Eight percent of patients diagnosed with pelvic inflammatory disease were admitted to the hospital. However, treatment for female patients with pelvic inflammatory disease was fully compliant with CDC recommendations in only 35% of cases (95% confidence interval [CI] 19% to 45%) and partially compliant in another 45%; 20% (95% CI 12% to 31%) of patients received either no treatment or treatment not in accordance with guidelines. Male patients were more likely to be treated for sexually transmitted infection (adjusted odds ratio [OR] 6.3; 95% CI 1.0 to 38.7), and Hispanic patients were less likely (adjusted OR 0.3; 95% CI 0.1 to 0.9) to be treated. Age, insurance type, and hospital location were not a factor in receiving antibiotics. For female patients who had a sexually transmitted infection, only 43% had a pregnancy test done, and of all adolescents diagnosed with a sexually transmitted infection, only 1 (0.3%) had an HIV test performed. CONCLUSION: Significant numbers of adolescents sought care for sexually transmitted infections in US EDs. Evaluation and treatment of these adolescents is not optimal. Male patients are more likely to be treated for a sexually transmitted infection. Hispanic patients are less likely to be treated for a sexually transmitted infection. Pelvic inflammatory disease is not always treated with antibiotics, and few patients with pelvic inflammatory disease are admitted to the hospital. HIV testing was almost never done. Further study is necessary to explain these disparities and optimize care.

Adolescent↗

PubMed2004

Validity and responsiveness of a brief, asthma-specific quality-of-life instrument in children with acute asthma.

OBJECTIVE: To test the validity and short-term responsiveness to change of a pediatric, asthma-specific, health-related quality-of-life (HRQL) instrument. METHODS: Children 2 years and older treated in the emergency department (ED) for acute asthma were eligible for this prospective cohort study. A 10-item instrument, the Integrated Therapeutics Group Child Asthma Short Form (ITG-CASF), was administered at the time of the ED visit and again 14 days later (via telephone). At the follow-up call, parents were also asked about the child's current overall asthma status, missed school or limited activities, and persistence of asthma symptoms. RESULTS: A total of 121 children were enrolled (mean age, 7.9 years), and follow-up was complete for 96 (79%). Mean +/- SD ITG-CASF scores at follow-up were significantly higher among children reported to have improved overall (61.8 +/- 19.6) than those not improved (41.9 +/- 21.2), and there was a significant correlation between ITG-CASF score at follow-up and the number of days of school missed or limited activities (r = -0.45; 95% confidence interval [CI], -0.24 to -0.66). There was also a significant difference in improvement in ITG-CASF score from ED visit to follow-up among those improved (13.7-point improvement) compared with those not improved (3.3-point improvement; difference = 10.4; 95% CI, 1.2 to 19.5). The effect size was 0.68, indicating a large responsiveness to change. CONCLUSIONS: The ITG-CASF is a valid and responsive measure of HRQL in children with acute asthma and may be a useful outcome measure in evaluating ED treatment.

Acute Disease↗

PubMed2004

Difficulty in obtaining peak expiratory flow measurements in children with acute asthma.

OBJECTIVE: To determine the frequency with which children >or=6 years with acute asthma can perform peak expiratory flow rate measurements (PEFR) in an emergency department (ED). DESIGN/METHODS: Data were obtained from a prospective cohort study of children with acute asthma. All children (age 2-18 years old) treated in an urban pediatric ED for an acute exacerbation during randomly selected days over a 12-month period were prospectively evaluated. According to treatment protocols, PEFR was to be measured in all children age 6 years and older before therapy and after each treatment with inhaled bronchodilators. Registered respiratory therapists obtained PEFR and evaluated whether patients were able to perform the maneuver adequately. RESULTS: Four hundred and fifty-six children, 6 to 18 years old (median 10 years), were enrolled; 291 (64%) had PEFR measured at least once. Of those in whom PEFR was attempted at least once, only 190 (65%) were able to perform adequately. At the start of therapy, 54% (142/262) were able to perform PEFR. Of the 120 who were unable to perform initially, 76 had another attempt at the end of the ED treatment, and 55 (72%) were still unable to perform. A total of 149 patients had attempts at PEFR both at the start and end of treatment, of these, only 71 (48%) provided valid information on both attempts. Patients unable to perform PEFR were younger (mean +/- SD = 8.7 +/- 2.8 years) than those who were able to perform successfully (11.2 +/- 3.2 years) and those with no attempts (10.0 +/- 3.4 years). Children admitted to the hospital were more likely to be unable to perform PEFR (58/126 = 46%) than those discharged from the ED (43/330 = 13%, P < 0.0001). CONCLUSION: Adequate PEFR measurements are difficult to obtain in children with acute asthma. Treatment and research protocols cannot rely exclusively on PEFR for evaluation of severity.

Acute Disease↗