Biomedical subjects

M von Knoch

Publications and source records attributed to M von Knoch.

At least 19 recordsLinked to original sources

PubMed2004

The accuracy of free-hand cup positioning--a CT based measurement of cup placement in 105 total hip arthroplasties.

We studied 105 patients who received a total hip arthroplasty between June 1985 and August 2001 using freehand positioning of the acetabular cup. Using pelvic CT scan and the hip-plan module of SurgiGATE-System (Medivision, Oberdorf, Switzerland), we measured the angles of inclination and anteversion of the cup. Mean inclination angle was 45.8 degrees +/-10.1 degrees (range: 23.0-71.5 degrees ) and mean anteversion angle was 27.3 degrees +/-15.0 degrees (range: -23.5 degrees to 59.0 degrees ). We compared the results to the "safe" position as defined by Lewinnek et al. and found that only 27/105 cups were implanted within the limits of the safe position. We conclude that a safe position as defined by Lewinnek et al. [13] was only achieved in a minority of the cups that were implanted freehand.

Adult↗

PubMed2004

Decrease in particle-induced osteolysis in obese (ob/ob) mice.

There may be variability in the susceptibility of different individuals to osteolysis from wear debris, and it is not clear whether some individuals may have a genetic predisposition for a more marked osteolytic response. The purpose of this study in mice was to determine whether genetically determined obesity can alter the response to particulate debris. Polyethylene particles were implanted onto the calvaria of seven wild-type mice and seven obese mice (ob/ob). Calvaria from unimplanted wild-type and obese mice served as controls. Calvaria were harvested after 7 days, stained with toluidine blue and for tartrate-specific alkaline phosphatase, and analyzed by histomorphometry. The osteoclast number per mm total bone perimeter was 8.000+/-3.464 in wild-type animals with particles and 2.857+/-1.676 in ob/ob animals with particles (p=0.002; Fisher's PLSD). Bone resorption was 1.895+/-0.713 mm/mm(2) in wild-type animals with particles and 1.265+/-0.494 mm/mm(2) in ob/ob animals with particles (p=0.0438; Fisher's PLSD). Particles induced a diminished osteolytic response in genetically determined obese mice, suggesting that obesity may have a protective role against particle-induced bone resorption-similar to obesity and osteoporosis. These important new findings may help to stimulate clinical studies which may define criteria to better identify patients at risk to develop particle-induced osteolysis.

Animals↗

PubMed2004

[Titanium as an implant material for rods of transpedicular instrumentation of the lumbar spine].

BACKGROUND AND AIM: Titanium alloys are increasingly being used as an implant material in orthopaedics and for spinal instrumentation. In this study a metallographic analysis and mechanical testing were performed to evaluate the resistance of rods of Ti-A16-V4 in particular to tensile forces. METHOD: The surface texture of unprepared Ti-A16-V4 and a rod of the same material for spinal instrumentation were evaluated in a metallographic analysis using light microscopy and electron microscopy. Tensile strength measurements were performed on 2 rods, and the strength of the connection between rod and pedicle screws was tested in 9 cases. An electron microscopic analysis of surface changes of the connections between rod and pedicle screws after loading was performed. RESULTS: The titanium alloy Ti-A16-V4 has a mill-annealed appearance, which has a high resistance to tearing under stress. Titanium rods show high tensile strength before failure under loading. The connection between rod and pedicle screws also as high resistance to tensile loads (> 27 kN) with only little deformation of the connecting surface and no tearing. CONCLUSION: The titanium alloy Ti-A16-V4 is an appropriate material for dorsal spinal instrumentation rods because of its low weight, high biocompability and high tensile strength.

Alloys↗

PubMed2003

Periprosthetic fractures with extensive bone loss treated with onlay strut allografts.

We reviewed a consecutive series of 19 patients with comminuted periprosthetic fractures, loosening of the femoral stem (Vancouver type B3) and significant loss of bone stock (Paprosky type III and IV). Sixteen porous-coated long stems and three Exeter stems, all with impaction grafting, were used. Large femoral onlay strut allografts were applied to maintain fracture reduction and improve stability. There was one early re-fracture at the tip of the femoral stem. Eighteen fractures healed without deformity and shortening. At the last follow-up at mean 3.7 (2.0-7.5) years, the mean Harris hip score was 76.4 (57.5-92.0). There was ingrowth of all strut grafts and significant augmentation of periprosthetic bone.

Adult↗

PubMed2002

Spontaneous fusion of 'os acetabuli' after triple pelvic osteotomy.

In acetabular dysplasia, an overloading of the acetabular rim can cause a stress fracture, creating an 'os acetabuli', or a lesion of the acetabular labrum. At puberty, the os acetabuli seems to be the epiphysis of the os pubis. We present the case of a 14-year-old girl with acetabular dysplasia and spontaneous fusion of an 'os acetabuli' after biomechanical correction by triple pelvic osteotomy. Our report supports the correctness of the biomechanical principle: reorientation of the acetabulum results in a better coverage of the femoral head, reduces the stress at the acetabular rim, shifts the os acetabuli out of the stress region, and may allow union of the bony fragment with the acetabulum.

Acetabulum↗

PubMed2002

[Holistic thinking in medicine--do we need a medical philosophy? Current efforts to think beyond the limits of school medicine, needs for systematic standardization].

The increasing debate dealing with topics of medicine and with medicine itself necessitates a scientific and systematic approach to the reality of medicine as a whole. This can be accomplished by the philosophy of medicine. For the purpose of reorientation of this discipline a division into notices of medicine, aesthetics of medicine and ethics of medicine is proposed.

Austria↗

PubMed2002

[Surface cleaning of cemented orthopedic implants with conservation of surface properties].

Prior to the analysis of explanted cemented orthopedic implants, complete removal of foreign material, blood and residual tissue and thorough cleaning of the surface without compromising its characteristics is essential. We describe a reprocessing procedure comprising the following 4 steps: 1) retrieval and storage, 2) removal of residual bone cement, 3) chemical cleaning in an enzymatic solution, and 4) mechanical cleaning in an ultrasound bath.

Bone Cements↗

PubMed2001

Total knee arthroplasty in a patient with chronic occlusion of the superficial femoral artery.

In a 67-year-old patient with severe valgus gonarthrosis and chronic occlusion of the superficial femoral artery on the same side, total knee replacement was performed without preceding angioplasty because the collateral circulation was intact. No tourniquet was used. To leave the peripatellar arterial ring intact on one side in this case of lateral patellar maltracking, a lateral approach was used. In this approach, a lateral release forms part of the approach itself. To achieve gentle eversion of the patella, the tibial tubercle was osteotomized. One year postoperatively, the patient was satisfied with the outcome and showed no clinical signs of any vascular deterioration. It is concluded that total knee replacement may be possible in the presence of chronic occlusion of the superficial femoral artery provided that the collateral circulation is intact.

Aged↗

PubMed2001

Intracellular measurement of polyethylene particles. A histomorphometric study.

A histological and histomorphometric study was carried out on pseudo-capsules retrieved from patients during revision surgery of cementless total hip replacement. Polyethylene loading and areal polyethylene particle size in different cells of the reticuloendothelial cell line were determined within the tissue by histomorphometry. In the reticuloendothelial cell line, foreign-body giant cells are considered to be the result of confluence of mononuclear macrophages caused by large particles or other unknown stimuli. The aim of this study was to investigate whether polyethylene particle size and polyethylene loading are different in mononuclear macrophages and foreign-body giant cells. The specimens were examined under the light-optical microscope with plain and polarized light. The polyethylene loading of 329 macrophages (mononuclear), 81 small foreign-body giant cells (2-5 visible nuclei), and 103 large foreign-body giant cells (6 or more visible nuclei) was determined and the intracellular polyethylene particle size analyzed by histomorphometry. The mean polyethylene loading was 13 +/- 8 microm2, 25 +/- 16 microm2, and 49 +/- 42 microm2, respectively. This difference was statistically significant (Student's t-test, P < 0.05). The mean polyethylene particle size was 2.34 +/- 3.2 microm2, 3.02 +/- 3.46 microm2, and 4.70 +/- 11.25 microm2, respectively. This difference was statistically significant between macrophages and large foreign-body giant cells (t-test, P < 0.05). The findings of this light-optical study show that the mean intracellular polyethylene particle size is greater in foreign-body giant cells. In addition, absolute polyethylene loading tends to be higher in foreign-body giant cells than in mononuclear macrophages.

Female↗

PubMed2001

Magnetic resonance arthrography of the acetabular labrum: value of radial reconstructions.

The intention was to compare the sensitivity and specificity of radial planes with oblique coronal and oblique axial planes for the detection of labral abnormalities of the acetabulum on magnetic resonance arthrography (MRa). Twenty cadaveric hip joints were examined by radiography and MRa. For MRa, 15 ml of a solution of iodinated contrast material and gadolinium diethylene triamine tetra-acetic acid (Gd-DTPA; 100:1) were injected under fluoroscopic guidance. MRI was performed on a 1.5-T MR scanner with a fat-suppressed 3D-FLASH sequence (TR/TE/flip-angle 42 ms/10 ms/40 degrees; field of view 16 cm, matrix 256 x 256, section thickness 1.5 mm, pixel size 0.7 x 0.7 mm). Multiplanar image reconstructions were done perpendicular to the acetabulum in oblique coronal and oblique axial planes and in radial planes. Macroscopic and histopathologic examination of the labral specimens was performed. Labral lesions were found in 15/20 hips (75%) on pathologic examination. Six hips demonstrated labral degeneration. The labrum was partially detached in 7 hips and completely detached in 2 hips. A flap-like labrum was found in 2 cases, 1 with partial detachment of the labrum and 1 with a degenerated labrum. Using oblique coronal and oblique axial reconstructions, pathologic findings were confirmed by MRa in 9/15 specimens (sensitivity 60%). There were no false-positive findings (specificity 100%, accuracy 70%). Also, 3/6 labral degenerations without detachment, 4/7 partial detachments, and 2/2 complete detachments were correctly diagnosed. Two flap-like labra were not recognized. With radial reconstructions, pathologic findings were correctly confirmed in 12/15 specimens (sensitivity 80%) without false-positive findings (specificity 100%, accuracy 85%). Also, 3/6 labral degenerations without detachment, 6/7 partial detachments, 2/2 complete detachments, and 1/2 flap-like labra were correctly diagnosed. MRa of the acetabular labrum using radial reconstructions is well suited to delineate the acetabular labrum and to diagnose labral detachments. Radial reconstructions allow for perpendicular display of the whole acetabular circumference and are more accurate for the diagnosis of acetabular labral lesions, when compared with oblique coronal and oblique axial reconstructions.

Acetabulum↗

PubMed2001

Skeletal cystic angiomatosis with severe hip joint deformation resembling massive osteolysis.

An aggressive destruction pattern resulting in joint deformation has not been described in skeletal cystic angiomatosis (SCA) so far. We present the case of a 6-year-old boy with such findings strongly resembling Gorham's disease (massive osteolysis). Since the prognosis of the latter entity tends to be less favorable than in SCA, particularly SCA without extraskeletal involvement, careful differentiation of both disorders appears to be important.

Angiomatosis↗

PubMed2000

Migration of polyethylene wear debris in one type of uncemented femoral component with circumferential porous coating: an autopsy study of 5 femurs.

This autopsy study analyzed the migration of polyethylene wear debris adjacent to uncemented femoral components with circumferential porous coating. Five femoral specimens retrieved at autopsy from 3 patients were investigated. Two stems were 40% porous coated, 2 were 80% porous coated, and 1 was 100% porous coated. The implants' time in situ ranged from 53 to 132 months (average, 94.8 months). All patients were followed clinically and radiographically until death. Radiographically, 3 of the stems were bone ingrown with proximal bone loss, 1 stem was mainly fibrous encapsulated, and 1 stem was completely fibrous encapsulated. Histologic examination of bone adjacent to the middle and distal sections of the femoral implant revealed no polyethylene wear debris or granulation tissue in any of the specimens. In 2 bone-ingrown cases, a small number of polyethylene particles and small areas of granulation tissue were present at the proximal level. This granulation tissue, however, did not cause major osteolysis. The findings in this study imply that circumferential porous coating of cementless femoral components could prevent distal migration of polyethylene wear debris along the bone-implant interface in both bone-ingrown and fibrous-encapsulated femoral implants.

Aged↗

PubMed1999

Unsuccessful surgical treatment of hip dislocation in congenital sensory neuropathy with anhidrosis. A case report.

A six-year-old girl with congenital sensory neuropathy with anhidrosis (CSNA) presented with bilateral hip dysplasia and subluxation on the right side. Conservative treatment of the hips by closed reduction and a plaster cast was unsuccessful. When aged seven years the patient had an intertrochanteric varus rotation osteotomy on the right side, but subluxation was again evident after five months. A Salter-type pelvic osteotomy was carried out followed by immobilisation, but one year later subluxation was present in the right hip and dislocation in the left. At the age of nine years, the right femoral head resembled a Charcot joint, although walking ability was preserved. In patients with CSNA, surgery may not always be advisable.

Child↗

PubMed1999

Lateral approach with osteotomy of the tibial tubercle in primary total knee arthroplasty.

In a prospective study of 51 patients (61 cases) with primary total knee arthroplasty (valgus knees and/or knees that had undergone previous nonarthroplasty surgery), a lateral approach with osteotomy of the tibial tubercle was performed. In a lateral approach, lateral release techniques form part of the approach. In addition, the medial blood supply to the patella is preserved. An additional tibial osteotomy grants wide exposure with little tension on the extensor mechanism during eversion of the patella. The patients were followed up clinically (51 patients, 61 cases) and radiologically (44 patients, 52 cases) for 1 year. No postoperative tibial fractures, no delayed unions, and no nonunions at the site of the osteotomy were seen. No patellar necrosis occurred. The results after 1 year were good or excellent in 45 (88%) patients, fair in four (8%), and poor in two (4%). Complications related to technique were hematoma (four patients) and compartment syndrome (one patient). These complications occurred early in the series and were eliminated by technical modifications.

Aged↗

PubMed1997

Incidence of late bead shedding from uncemented porous coated cups. A radiographic evaluation.

A radiographic study was performed on late head separation from the porous surface of clinically well functioning and radiographically stable Arthropor uncemented acetabular components. Of 104 cups in 102 patients, 11 (10.6%) showed bead separation from the porous coated surface. Bead shedding occurred at an average of 4.2 years (range, 2-7 years). In each case the phenomenon was progressive. In the group that shed beads, there was a higher prevalence of acetabular radiolucencies (63.6% versus 25.8%) and of osteolysis (45.5% versus 10.8%). These differences were statistically significant. The group that shed beads also had a higher polyethylene wear rate (0.21 mm/year versus 0.16 mm/year) and were younger (49.5 years versus 59.5 years). All cups that shed beads remained clinically and radiographically stable. Thus, the clinical impact of these observations is uncertain. However, the higher prevalence of acetabular lucencies and osteolysis in these patients, in combination with an increased polyethylene wear rate, require thorough clinical and radiographic followup to uncover potential loosening problems of these acetabular components.

Acetabulum↗

PubMedDate not supplied

[Knee flexion after rotational knee endoprosthesis].

UNLABELLED: In the presented study the question was evaluated if--after rotational knee arthroplasty--range of motion must be restored at discharge or if range of motion can also be restored with delay during the first postoperative year. METHOD: A retrospective study was performed on 45 patients. These had been rehabilitated with a specific therapeutical concept which did not include early restoration at discharge of complete range of motion as the key principle. RESULTS: The mean range of motion was 60 degrees +/- 21 degrees at discharge. At the date of presentation 12 to 18 months postoperatively the mean range of motion had improved to 110 degrees +/- 19 degrees. CONCLUSIONS: The presented study indicates that complete restoration of range of motion after rotational knee arthroplasty may not necessarily be restored at discharge.

Aftercare↗

PubMedDate not supplied

[Polyethylene content and cell size of foreign body giant cells in aseptic hip prosthesis loosening--a histomorphometric study].

INTRODUCTION: In aseptic loosening of cementless hip arthroplasty polyethylene particles are phagocytized by macrophages and foreign-body giant cells. This initiates an osteolytic cascade. In this study, the authors investigated if there are correlations between the size of foreign-body giant cells and the polyethylene loading and number of intracellular particles as determined by light microscopy. MATERIAL AND METHOD: Histological specimens were processed from tissues retrieved during revision surgery of 7 cases of cementless hip arthroplasty which had become aseptically loose. The specimens were analyzed by histolomorphology and histomorphometry. The cell size, polyethylene loading and intracellular particle number of 111 foreign-body giant cells were determined. A regression analysis was performed to investigate if there was a correlation between these variables. RESULTS: The mean cell size was 1417 +/- 487 micron 2, the mean polyethylene loading was 49 +/- 42 micron 2 and the mean intracellular particle number was 10.4 +/- 5.4. The cell size correlated with both the intracellular particle number (r = 0.25) and the polyethylene loading (r = 0.39). CONCLUSIONS: In the cellular reaction to polyethylene particles in aseptic loosening of cementless total hip arthroplasty, the size of foreign-body giant cells correlates with intracellular polyethylene loading and intracellular polyethylene particle number as determined by light microscopy. The presence of large foreign body giant cells might be associated with a high particle load of the tissue and a high osteolytic activity.

Aged↗

PubMedDate not supplied

[Fracture behavior of AO 3.5 mm cortical titanium screws Synthes screws) combined with LC-DCP plates].

AIM: It was investigated if AO 3.5-mm titanium cortical screws used in combination with LC-DCP plates for osteosynthesis are likely to break during surgery. METHOD: The moments of torque that lead to breakage of the screw were determined experimentally in a hardwood model. The insertion angle was variable: 90 degrees in centric (n = 30) and excentric (n = 30) positioning, 70 degrees (n = 30) and 50 degrees (n = 30). Minimal moments that led to screw breakage were compared to insertion moments that were measured intraoperatively in 7 fracture operations (radial, ulnar, tibial, fibular; 32 screws). RESULTS: Minimal moments that led to screw breakage were 2.6 Nm (90 degrees centric), 2.8 Nm (90 degrees eccentric), 2.7 Nm (70 degrees) and 2.4 Nm (50 degrees). The maximal intraoperatively measured insertion moment was 2.25 Nm (radius). CONCLUSIONS: In this investigation, minimal moments that led to screw breakage in an experimental setting were higher than maximal insertion moments that were recorded during surgery. It is concluded that screw breakage related to the given implant combination is unlikely if correct surgical technique is performed.

Bone Plates↗